Neonatal thyrotoxicosis is associated with transplacental passage of human thyroid stimulating immunoglobulin (HTSI).

Mitchell, Ian; Shenfield, Gillian M.; Brash, J. H.

doi:10.1136/adc.51.7.565

Cited by 14 publications

(1 citation statement)

References 11 publications

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“…Once the cord has been cut at birth and the supply of maternal TSAb to the infant discontinued, it might be expected that the time course of neonatal thyrotoxicosis would follow the disappearance of TSAb from the infant's plasma. The half-life ( t~) of TSAb in the neonatal thyrotoxic has been estimated at 6-10 days (Sunshine et al, 1965;Mitchell et al, 1976) but TSAb concentrations are known to correlate poorly with serum thyroid hormone levels (TH) in adults (Mukhtar et al, 1975). The aim of the work described in this paper was to establish the behaviour of T3 and T4 in an untreated case of neonatal thyrotoxicosis.…”

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confidence: 99%

The Behaviour of Thyroid Hormones in an Infant With Untreated Neonatal Thyrotoxicosis

Wilkin

Kenyon

Isles

1977

Clinical Endocrinology

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The clinical course from birth and serial measurements of serum T3, T4 and TSH in an infant with untreated neonatal thyrotoxicosis are reported. The thyroid hormone levels fell exponentially with time at rates very much slower than those previously reported for the maternally-transmitted thyroid stimulating antibody generally thought to cause the disorder. Steady physiological levels of thyroid hormones were achieved after 110 days (serum T3 = 3.4 NMOL/L, T4 = 118 nmol/l). TSH first rose to a measurable level after about 90 days.

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mentioning

confidence: 99%

The Behaviour of Thyroid Hormones in an Infant With Untreated Neonatal Thyrotoxicosis

Wilkin

Kenyon

Isles

1977

Clinical Endocrinology

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Neonatal Thyrotoxicosis in Four Siblings Born to a Previously Thyrotoxic Mother

Bottenfield¹

1978

Arch Pediatr Adolesc Med

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Neocortical anomalies in autoimmune mice: A model for the developmental neuropathology seen in the dyslexic brain

Sherman

Rosen

Galaburda

1988

Drug Development Research

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Developmental ectopias (nests of neurons) in the molecular layer of the cerebral neocortex and associated dysplasias of underlying layers have been seen in two strains of mice (New Zealand Black and BXSB) that spontaneously develop autoimmune disorders. The ectopias are usually unilateral and males are more often affected than females. The emerging situation is comparable to that of male dyslexics who in addition to their language problems show similar developmental brain anomalies. These anomalies are thought to have their origin during the last stages of neuronal migration. We believe that maternal autoantibodies passing through the placenta and blood-brain barrier may damage the important structural components of the cerebral cortex affecting the final positions of migrating neurons. The autoimmune mice are a useful experimental animal model for understanding the development of neuropathology in dyslexics.

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Neonatal thyrotoxicosis is associated with transplacental passage of human thyroid stimulating immunoglobulin (HTSI).

Abstract: A woman who developed thyrotoxicosis during pregnancy had a high level of HTSI at the time of delivery. The baby had high levels of HTSI initially but, unlike the mother, the levels fell, giving a half-life of HTSI of 10 days.

Cited by 14 publications

References 11 publications

The Behaviour of Thyroid Hormones in an Infant With Untreated Neonatal Thyrotoxicosis

The Behaviour of Thyroid Hormones in an Infant With Untreated Neonatal Thyrotoxicosis

Neonatal Thyrotoxicosis in Four Siblings Born to a Previously Thyrotoxic Mother

Neocortical anomalies in autoimmune mice: A model for the developmental neuropathology seen in the dyslexic brain

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