Neonicotinoid insecticides: an emerging cause of acute pesticide poisoning

Abstract

Neonicotinoids are a new class of insecticides widely applied for crop protection. Information on human exposures to neonicotinoids is limited. The most common routes of exposure were ingestion (51%), dermal (44%), and ocular (11%). These insecticides act as agonists at nicotinic acetylcholine receptors, which cause insect paralysis and death the high specificity for receptors in insects was considered to possess highly selective toxicity to insects and relative sparing of mammals. However, an increasing number of cases of acute neonicotinoid poisoning have been reported in recent years. Present study report three cases presented to us with acute neonicotinoid poisoning with different manifestations including acute myocardial infarction, central nervous system (CNS) depression, and acute kidney injury, who recovered subsequently with supportive care. A detailed literature review found that respiratory, cardiovascular and certain neurological presentations are warning signs of severe neonicotinoid intoxication. Supportive treatment and decontamination are the practical methods for the management of all neonicotinoid-poisoned patients.

Quantitation of Pesticides in 89 Rice Samples by Liquid Chromatography– Mass Spectrometry: Analysis of Delhi NCR

“…Along with 7.86% samples having pesticide residues more than MRL and 91% samples were found no pesticide residues of total tested samples. The detected pesticide thiamethoxam, tricyclazole, clothianidin, and imidacloprid can lead to acute kidney injury by tubular toxicity through α7 nicotinic receptor inhibition, rhabdomyolysis, leucocytoclastic vacuities and secondary sepsis(Ramanathan et al 2020;Iyyadurai et al 2010;Bansal et al 2019;Agha et al 2012). Hence, it is required to monitor pesticide residues in different agricultural crops to have good health of citizen and trade as well.…”