Neoplasia

Sharp, Nancy

doi:10.1016/b978-0-7234-3209-8.50016-9

Cited by 9 publications

(12 citation statements)

References 77 publications

(155 reference statements)

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“…These neurological results revealed that the lesion extended at least into the spinal canal. A partial biopsy of the C8 spinal nerve was thus performed using an approach method [ 12 ].…”

mentioning

confidence: 99%

Extranodal Lymphoma with Peripheral Nervous System Involvement in a Dog

Ueno

Miyoshi

Fukui

et al. 2014

The Journal of Veterinary Medical Science

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An 8-year-old neutered female Cavalier King Charles spaniel was evaluated for progressing right forelimb lameness. Magnetic resonance imaging revealed that the right-side radial nerves and the caudal brachial plexus were swollen. The histological and molecular biological diagnosis by partial biopsy of the C8 spinal nerve was T-cell lymphoma. Coadministration of lomustine and irradiation was started. However, this therapy was ineffective. At necropsy, neoplastic tissues were seen extending into the subarachnoid space of the spinal cord, liver, pancreas and kidneys as gross findings. A large mass was also identified occupying the caudal thorax. Histologic findings included infiltration in these organs and the mass by neoplastic lymphocytes. To date, involvement of peripheral nerves (neurolymphomatosis) is rarely reported in veterinary species.

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“…These neurological results revealed that the lesion extended at least into the spinal canal. A partial biopsy of the C8 spinal nerve was thus performed using an approach method [ 12 ].…”

mentioning

confidence: 99%

Extranodal Lymphoma with Peripheral Nervous System Involvement in a Dog

Ueno

Miyoshi

Fukui

et al. 2014

The Journal of Veterinary Medical Science

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“…The main goals of surgical intervention in these conditions are to decrease pain and improve neurological function of the innervated structures (Toombs and others 2003, Sharp and Wheeler 2005). It is generally accepted that surgical treatment is indicated in cases that are non-responsive to medical treatment (Levine and others 2007).…”

Section: Discussionmentioning

confidence: 99%

Surgical management of a coccygeal intervertebral discal hernia in a dog

Cariou¹,

Denning

2017

Vet Record Case Reports

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A case of paresis of the tail and associated pain arising from caudal intervertebral disc disease in a six-year-old cocker spaniel is described. The dog had a chronic history of low tail carriage, decreased mobility and episodes of acute pain. Neurological evaluation was consistent with a lesion involving the caudal part of the cauda equina. CT evaluation was consistent with a disc herniation at the intervertebral disc space Cd1-Cd2. Surgical decompression was performed by a combination of hemilaminectomy and lateral corpectomy. The dog had a successful long-term outcome with complete resolution of its presenting clinical signs.

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“…A dorsal laminectomy was performed from the caudal portion of the L2 spinous process to caudal to the L3 spinous process, extending ventrolateral to the L2–L3 articular facet joints. 1 Vertebral stabilisation was performed using 1.5 mm titanium screws, which were placed bilaterally on the pedicles of L1, L2, L3 and L4 and embedded in polymethylmethacrylate (PMMA) cement. Implant entry points were estimated by visual approximation from the preoperative surgical planning video recording of the three-dimensional reconstruction, and drilling direction was guided by premeasured numeric values of inclination angles and osteotomy wedge gauges.…”

Section: Case Descriptionmentioning

confidence: 99%

Vertebral giant cell tumour of bone in a domestic shorthair cat

Carrete¹,

Tabanez²,

Civello³

et al. 2023

Journal of Feline Medicine and Surgery Open Reports

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Case summary A 10-year-old male neutered domestic shorthair cat was presented with a 5-month history of progressive non-ambulatory paraparesis. Initial vertebral column radiographs revealed an L2–L3 expansile osteolytic lesion. Spinal MRI showed a well-demarcated, compressive expansile extradural mass lesion affecting the caudal lamina, caudal articular processes and right pedicle of the second lumbar vertebra. The mass was hypointense/isointense on T2-weighted images, isointense on T1-weighted images and had mild homogeneous contrast enhancement after gadolinium administration. MRI of the remaining neuroaxis and CT of the neck, thorax and abdomen with ioversol contrast revealed no additional neoplastic foci. The lesion was removed by en bloc resection via a dorsal L2–L3 laminectomy, including the articular process joints and pedicles. Vertebral stabilisation was performed with titanium screws placed within L1, L2, L3 and L4 pedicles with polymethylmethacrylate cement embedding. Histopathology revealed an osteoproductive neoplasm composed of spindle and multinucleated giant cells without detectable cellular atypia or mitotic activity. On immunohistochemical evaluation, osterix, ionised calcium-binding adaptor molecule 1 and vimentin labelling were observed. Based on the clinical and histological features, a giant cell tumour of bone was considered most likely. Follow-up at 3 and 24 weeks postoperatively demonstrated significant neurological improvement. Postoperative full-body CT at 6 months showed instability of the stabilisation construct but absence of local recurrence or metastasis. Relevance and novel information This is the first reported case of a giant cell tumour of bone in the vertebra of a cat. We present the imaging findings, surgical treatment, histopathology, immunohistochemistry and outcome of this rare neoplasm.

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Neoplasia

Cited by 9 publications

References 77 publications

Extranodal Lymphoma with Peripheral Nervous System Involvement in a Dog

Extranodal Lymphoma with Peripheral Nervous System Involvement in a Dog

Surgical management of a coccygeal intervertebral discal hernia in a dog

Vertebral giant cell tumour of bone in a domestic shorthair cat

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