Neoplastic development in plasma cells

Potter, Michael

doi:10.1034/j.1600-065x.2003.00061.x

Cited by 117 publications

(120 citation statements)

References 131 publications

(135 reference statements)

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“…3--6 MYC is also central in two other B cell-derived tumors, namely plasmacytomas and Burkitt's lymphoma where translocations of IGH-MYC are major oncogenic events. 7 Overexpression of MYC occurs by different mechanisms including gene amplification, translocation and mutation. MYC chromosomal rearrangements are present in many myeloma cell lines, 8,9 and to a varying degree (15--46%) in primary myeloma cells.…”

Section: Introductionmentioning

confidence: 99%

Bone morphogenetic proteins induce apoptosis in multiple myeloma cells by Smad-dependent repression of MYC

et al. 2011

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Bone morphogenetic proteins (BMPs) have been shown to induce apoptosis and growth arrest in myeloma cells. However, the molecular mechanisms behind these events are not known. The MYC oncogene is a master regulator of cell growth and protein synthesis and MYC overexpression has been proposed to be associated with the progression of multiple myeloma. Here, we show that BMP-induced apoptosis in myeloma cells is dependent on downregulation of MYC. Moreover, the results suggest that targeting the MYC addiction in multiple myeloma is an efficient way of killing a majority of primary myeloma clones. We also found that myeloma cells harboring immunoglobulin (IG)-MYC translocations evaded BMP-induced apoptosis, suggesting a novel way for myeloma cells to overcome potential tumor suppression by BMPs.

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Section: Introductionmentioning

confidence: 99%

Bone morphogenetic proteins induce apoptosis in multiple myeloma cells by Smad-dependent repression of MYC

et al. 2011

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“…This is illustrated by the plasmocytomas that can be obtained in some mice model in which the PC proliferation develop in close contact with IL-6-producing inflammatory feeder cells that are induced by peritoneal irritation. 24 Hyperproduction of the parathyroid hormone, which results in high IL-6 production in the BM, might also favor the emergence of a PC proliferation. 25 Alternatively, instead of being involved in the early step of the MM emergence, IL-6 overproduction by MSCs might result from transforming effect of the myeloma cells that would persist in remission favoring the occurrence of a subsequent relapse.…”

Section: Discussionmentioning

confidence: 99%

Phenotypic and functional characterization of bone marrow mesenchymal stem cells derived from patients with multiple myeloma

et al. 2006

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“…These foci can be observed already at 25 days after pristane injection, while the latent period for plasmacytoma formation is on average 215 days. The major contribution from the lipogranulomas in plasmacytoma development appears to be the production of IL-6 (Potter, 2003).…”

Section: Plasmacytomasmentioning

confidence: 99%

“…injection of pristane (and paraffin oils in the range of C 14 -C 19 ) in mice led to a chronic inflammatory response and the formation of lipogranulomas on peritoneal surfaces (reviewed by Potter, 2003). The lipogranulomas are formed after phagocytosis of oil droplets by myeloid cells/macrophages, and adherence to larger oil droplets.…”

Section: Lipogranulomasmentioning

confidence: 99%

Scientific Opinion on Mineral Oil Hydrocarbons in Food

2012

EFS2

107

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Consumers are exposed to a range of mineral oil hydrocarbons (MOH) via food. Mineral oil saturated hydrocarbons (MOSH) consist of linear and branched alkanes, and alkyl-substituted cyclo-alkanes, whilst mineral oil aromatic hydrocarbons (MOAH) include mainly alkyl-substituted polyaromatic hydrocarbons. Products, commonly specified according to their physico-chemical properties, may differ in chemical composition depending on the oil source. Technical grade MOH contain 15 -35 % MOAH, which is minimised in food grade MOSH (white oils). Major sources of MOH in food are food packaging and additives, processing aids, and lubricants. Estimated MOSH exposure ranged from 0.03 to 0.3 mg/kg b.w. per day, with higher exposure in children. Specific production practices of bread and grains may provide additional MOSH exposure. Except for white oils, exposure to MOAH is about 20 % of that of MOSH. Absorption of alkanes with carbon number above C 35 is negligible. Branched and cyclic alkanes are less efficiently oxidised than n-alkanes. MOSH from C 16 to C 35 may accumulate and cause microgranulomas in several tissues including lymph nodes, spleen and liver. Hepatic microgranulomas associated with inflammation in Fischer 344 rats were considered the critical effect. The no-observed-adverse-effect level for induction of liver microgranulomas by the most potent MOSH, 19 mg/kg b.w. per day, was used as a Reference Point for calculating margins of exposure (MOEs) for background MOSH exposure. MOEs ranged from 59 to 680. Hence, background exposure to MOSH via food in 1 On request from the European Commission, Question No EFSA-Q-2010-00170, adopted on 3 May 2012. 2 SUMMARYFollowing a request from the European Commission, the EFSA Panel on Contaminants in the Food Chain (CONTAM Panel) was asked to deliver a scientific opinion on mineral oil hydrocarbons (MOH) in Food. Mineral oil hydrocarbons occur in food both as a result of contamination and from various intentional uses in food production. In order to assess the need for possible regulatory measures as regards MOH in food, EFSA was requested to assess the risks related to their occurrence in food. More specifically, the opinion should evaluate whether new toxicity data are available and whether the current acceptable daily intakes (ADIs) are still applicable, explore whether certain classes (or subclasses) of MOH are more relevant due to their toxicity or to differences in the way they are metabolised by the human body, and identify the different background sources, other than from adulteration or misuse, of MOH occurrence in food. In addition a dietary exposure assessment was requested for the general population and for specific subgroups of the population (e.g. infants, children and people following specific diets), by taking into account the background occurrence of MOH in food. Included in the request was also to advise on MOH and food classes to be included if monitoring were to be set up for their presence in food.The scientific literature and other sources were s...

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Neoplastic development in plasma cells

Cited by 117 publications

References 131 publications

Bone morphogenetic proteins induce apoptosis in multiple myeloma cells by Smad-dependent repression of MYC

Bone morphogenetic proteins induce apoptosis in multiple myeloma cells by Smad-dependent repression of MYC

Phenotypic and functional characterization of bone marrow mesenchymal stem cells derived from patients with multiple myeloma

Scientific Opinion on Mineral Oil Hydrocarbons in Food

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