Neoplastic Diseases

Altman, Norman H.; Goodman, Dawn G.

doi:10.1016/b978-0-12-074901-0.50020-4

Cited by 22 publications

(8 citation statements)

References 75 publications

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“…Overall the tumor incidence in this study was similar to that reported in the literature. 21,22 Physical appearance Examination of retrieved pins revealed changes in their physical appearance. Poly(DTE adipate) pins retrieved as early as 2 days postimplantation were opaque and curved.…”

Section: In Vivo Evaluationsmentioning

confidence: 99%

Comparative histological evaluation of new tyrosine-derived polymers and poly (L-lactic acid) as a function of polymer degradation

Hooper

Macon

Kohn

1998

J. Biomed. Mater. Res.

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Previous studies demonstrated that poly(DTE carbonate) and poly (DTE adipate), two tyrosine-derived polymers, have suitable properties for use in biomedical applications. This study reports the evaluation of the in vivo tissue response to these polymers in comparison to poly(L-lactic acid) (PLLA). Typically, the biocompatibility of a material is determined through histological evaluations as a function of implantation time in a suitable animal model. However, due to changes that can occur in the tissue response at different stages of the degradation process, a fixed set of time points is not ideal for comparative evaluations of materials having different rates of degradation. Therefore the tissue response elicited by poly(DTE carbonate), poly(DTE adipate), and PLLA was evaluated as a function of molecular weight. This allowed the tissue response to be compared at corresponding stages of degradation. Poly(DTE adipate) consistently elicited the mildest tissue response, as judged by the width and lack of cellularity of the fibrous capsule formed around the implant. The tissue response to poly(DTE carbonate) was mild throughout the 570 day study. However, the response to PLLA fluctuated as a function of the degree of degradation, exhibiting an increase in the intensity of inflammation as the implant began to lose mass. At the completion of the study, tissue ingrowth into the degrading and disintegrating poly(DTE adipate) implant was evident while no comparative ingrowth of tissue was seen for PLLA. The similarity of the in vivo and in vitro degradation rates of each polymer confirmed the absence of enzymatic involvement in the degradation process. A comparison of molecular weight retention, water uptake, and mass loss in vivo with two commonly used in vitro systems [phosphate-buffered saline (PBS) and simulated body fluid (SBF)] demonstrated that for the two tyrosine-derived polymers the in vivo results were equally well simulated in vitro with PBS and SBF. However, for PLLA the in vivo results were better simulated in vitro using PBS.

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Section: In Vivo Evaluationsmentioning

confidence: 99%

Comparative histological evaluation of new tyrosine-derived polymers and poly (L-lactic acid) as a function of polymer degradation

Hooper

Macon

Kohn

1998

J. Biomed. Mater. Res.

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“…These two rat strains arc known to demonstrate different frequencies of various types of tumors (Bickerton. 1974: Altman andGoodman. 1979).…”

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confidence: 99%

A comparison of sister chromatid exchange frequencies in peripheral lymphocytes and bone marrow cells of Fischer 344 and Sprague-Dawley rats

Dearfield¹,

Jacobson‐Kram²,

Williams³

1984

Cytogenet Genome Res

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We have investigated spontaneous sister chromatid exchange (SCE) frequencies in peripheral lymphocytes and bone marrow cells explanted from two strains of the laboratory rat, Fischer 344 and Sprague-Dawley. A small, but significant difference was noted for both cell types, with the Fischer 344 rat being consistently higher. Other cell parameters, such as the mitotic index and the replicative index, were similar in the two strains. SCE levels in cultured peripheral lymphocytes after intraperitoneal administration of the alkylating drug cyclophosphamide (10 mg/kg) were similar for the two strains. Fischer 344 rats are known to have approximately a 10-fold higher incidence of spontaneous leukemia than do Sprague-Dawley rats. Since SCE frequency is a sensitive measure of DNA damage, our observations suggest that high leukemia incidence in the Fischer 344 rat may be related to a higher level of spontaneous DNA damage.

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“…The question of a pre-malignant role for polyps remains controversial. Endometrial polyps in rats have been described as endometrial tumours (Altman & Goodman, 1979); however, it is not clear whether these can routinely develop into malignancies.…”

Section: Resultsmentioning

confidence: 99%

Spontaneous endometrial tumours of 'Sabra' rats

Mor

Lutsky

1986

Lab Anim

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SummaryIn a 2 year study of 171 female (101 virgIn; 70 multiparous) 'Sabra' rats, spontaneous endometrial tumours were found in 69% of 2 year old animals. Tumour development appeared to be age related, and only virgin females showed tumours before 18 months of age. Polyps were the most prevalent tumour type, followed by adenocarcinomas. The Sabra rat can be included among those rat strains having a high incidence of spontaneous endometrial neoplasia.

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Neoplastic Diseases

Cited by 22 publications

References 75 publications

Comparative histological evaluation of new tyrosine-derived polymers and poly (L-lactic acid) as a function of polymer degradation

Comparative histological evaluation of new tyrosine-derived polymers and poly (L-lactic acid) as a function of polymer degradation

A comparison of sister chromatid exchange frequencies in peripheral lymphocytes and bone marrow cells of Fischer 344 and Sprague-Dawley rats

Spontaneous endometrial tumours of 'Sabra' rats

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