Neoteric solvents for the pharmaceutical industry: an update

Sekharan, T. Raja; Katari, Oly; Rahman, Syed Nazrin Ruhina; Pawde, Datta Maroti; Goswami, Abhinab; Chandira, Rajappa Margret; Shunmugaperumal, Tamilvanan

doi:10.1016/j.drudis.2021.03.005

Cited by 23 publications

(11 citation statements)

References 73 publications

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“…This class of solvents follow some of the 12 principles of green chemistry, as they come from a natural origin have low toxicity, are biodegradable, and minimize waste as much as possible. Among them are supercritical fluids, thermomorphic solvents, switchable solvents, liquid polymers, solvents derived from biomass, fluorinated solvents, ionic liquids (ILs), and deep eutectic solvents (DESs) [ 11 , 14 , 18 ].…”

Section: Deep Eutectic Solventsmentioning

confidence: 99%

“…But water has also some disadvantages, such as it does not dissolve nonpolar compounds due to the high dielectric constant (at room temperature and normal pressure), and it has a high boiling point which entails a high energetic cost for its removal. Additionally, the scarcity of water in some regions of the world and the possible contamination of the effluents due to difficulties during the separation processes are also problems associated with the use of water as a solvent [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

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A Comprehensive Review on Deep Eutectic Solvents and Its Use to Extract Bioactive Compounds of Pharmaceutical Interest

Ferreira,

Sarraguça

2024

Pharmaceuticals

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The extraction of bioactive compounds of pharmaceutical interest from natural sources has been significantly explored in recent decades. However, the extraction techniques used were not very efficient in terms of time and energy consumption; additionally, the solvents used for the extraction were harmful for the environment. To improve the environmental impact of the extractions and at the same time increase the extraction yields, several new extraction techniques were developed. Among the most used ones are ultrasound-assisted extraction and microwave-assisted extraction. These extraction techniques increased the yield and selectivity of the extraction in a smaller amount of time with a decrease in energy consumption. Nevertheless, a high volume of organic solvents was still used for the extraction, causing a subsequent environmental problem. Neoteric solvents appeared as green alternatives to organic solvents. Among the neoteric solvents, deep eutectic solvents were evidenced to be one of the best alternatives to organic solvents due to their intrinsic characteristics. These solvents are considered green solvents because they are made up of natural compounds such as sugars, amino acids, and carboxylic acids having low toxicity and high degradability. In addition, they are simple to prepare, with an atomic economy of 100%, with attractive physicochemical properties. Furthermore, the huge number of compounds that can be used to synthesize these solvents make them very useful in the extraction of bioactive compounds since they can be tailored to be selective towards a specific component or class of components. The main aim of this paper is to give a comprehensive review which describes the main properties, characteristics, and production methods of deep eutectic solvents as well as its application to extract from natural sources bioactive compounds with pharmaceutical interest. Additionally, an overview of the more recent and sustainable extraction techniques is also given.

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Section: Deep Eutectic Solventsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Comprehensive Review on Deep Eutectic Solvents and Its Use to Extract Bioactive Compounds of Pharmaceutical Interest

Ferreira,

Sarraguça

2024

Pharmaceuticals

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“…Neoteric solvents are good candidates to be used as co-solvents of SWE. Neoteric solvents have several interesting properties: they have a negligible vapor pressure, they are chemically and physically stable, and their polarity, hydrophilicity and solvent miscibility can be tunned depending on the intended application [129,130]. Neoteric solvents can be grouped into supercritical fluids, fluorinate solvents, ionic liquids, switched solvents, thermomorphic solvents, solvents derived from biomass, liquid polymers and DESs [130][131][132][133][134][135][136].…”

Section: Final Remarks and Future Perspectivesmentioning

confidence: 99%

Subcritical Water Extraction to Valorize Grape Biomass—A Step Closer to Circular Economy

Ferreira,

Moreira,

Delerue-Matos

et al. 2023

Molecules

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With the increase in the world population, the overexploitation of the planet’s natural resources is becoming a worldwide concern. Changes in the way humankind thinks about production and consumption must be undertaken to protect our planet and our way of living. For this change to occur, sustainable development together with a circular economic approach and responsible consumption are key points. Agriculture activities are responsible for more than 10% of the greenhouse gas emissions; moreover, by 2050, it is expected that food production will increase by 60%. The valorization of food waste is therefore of high importance to decrease the environmental footprint of agricultural activities. Fruits and vegetables are wildly consumed worldwide, and grapes are one of the main producers of greenhouse gases. Grape biomass is rich in bioactive compounds that can be used for the food, pharmaceutical and cosmetic industries, and their extraction from this food residue has been the target of several studies. Among the extraction techniques used for the recovery of bioactive compounds from food waste, subcritical water extraction (SWE) has been the least explored. SWE has several advantages over other extraction techniques such as microwave and ultrasound extraction, allowing high yields with the use of only water as the solvent. Therefore, it can be considered a green extraction method following two of the principles of green chemistry: the use of less hazardous synthesis (principle number 3) and the use of safer solvents and auxiliaries (principle number 5). In addition, two of the green extraction principles for natural products are also followed: the use of alternative solvents or water (principle number 2) and the use of a reduced, robust, controlled and safe unit operation (principle number 5). This review is an overview of the extraction process using the SWE of grape biomass in a perspective of the circular economy through valorization of the bioactive compounds extracted. Future perspectives applied to the SWE are also discussed, as well as its ability to be a green extraction technique.

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“…in the pharmaceutical industry. 5 Some of these new solvents are biomass derivatives, 6 supercritical fluids, 7 ionic liquids (ILs) 8 and deep eutectic solvents (DES). 9 According to the principles of Green Chemistry, 10 solvents should present low vapour pressures and high boiling points, good recyclability, high solvating power, be environmentally and humanly safe and have renewable origin.…”

Section: Introductionmentioning

confidence: 99%

Ecotoxicological study of bio-based deep eutectic solvents formed by glycerol derivatives in two aquatic biomodels

et al. 2022

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Neoteric solvents for the pharmaceutical industry: an update

Cited by 23 publications

References 73 publications

A Comprehensive Review on Deep Eutectic Solvents and Its Use to Extract Bioactive Compounds of Pharmaceutical Interest

A Comprehensive Review on Deep Eutectic Solvents and Its Use to Extract Bioactive Compounds of Pharmaceutical Interest

Subcritical Water Extraction to Valorize Grape Biomass—A Step Closer to Circular Economy

Ecotoxicological study of bio-based deep eutectic solvents formed by glycerol derivatives in two aquatic biomodels

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