Nephrogenic Rest in a Crl:CD (SD)IGS BR Rat

Jackson, Carney B.; Kirkpatrick, JB

doi:10.1354/vp.39-5-588

Cited by 6 publications

(9 citation statements)

References 7 publications

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“…This focal lesion did not affect the general architecture of the kidney. The morphologic features of the current lesion were similar to NR described in the rat (Jackson and Kirkpatrick 2002), except for the infiltrative and proliferative nature. Mesfin (1999) reported that, in addition to infiltrative blastemal cells with alveolar and rosette structures, presence of primitive tubules and glomeruli with high mitotic activity, especially in cells arranged in a tubular pattern, is indicative of early NB.…”

Section: Casesupporting

confidence: 75%

“…Hyperplastic and neoplastic rest are mitotically active and may show cellular atypia (Beckwith 1993;Lonergan et al 1998). Incipient NR has been reported in a SD rat (Jackson and Kirkpatrick 2002). Mesfin (1999) reported that ILNB of the rat could be equivalent to dormant NR of humans.…”

Section: Casementioning

confidence: 99%

“…It was found in the cortical interstitium and was composed of inconsistently distinct basophilic tubules lined by a single layer of cuboidal to columnar cells variably surrounded by blastemal cells, with formation of glomeruloid structures with no apparent compression or evidence of invasion of adjacent parenchyma. The lesion did not show evidence of proliferation, maturation, or involution (Jackson and Kirkpatrick 2002).…”

Section: Casementioning

confidence: 99%

“…However, the presence of primitive tubular and glomerular structures are also the feature of renal dysplasia and NR. Renal dysplasia is also associated with frequent mitotic figures (Jackson and Kirkpatrick 2002; Ruehl-Fehlert et al 2003). These observations are contrary to Mesfin’s (1999) criteria of early NB.…”

Section: Casementioning

confidence: 99%

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Intralobar Nephroblastematosis in a Nine-week-old Wistar Rat

Kalaiselvan¹,

Mathur²,

Pande³

et al. 2009

Toxicol Pathol

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Intralobar nephroblastematosis (ILNB) is a precursor lesion to the development of nephroblastoma (NB) in rats. Unilateral ILNB was observed in the kidney of a nine-week-old female Wistar rat (Crl:WI) from a short-term toxicity study. Clinical pathology and urinalysis did not reveal altered renal function. This microscopic, unencapsulated lesion consisted of basophilic sheets of blastemal cells that did not include a prominent mesenchymal component. These cells expanded in the interstitium, which trapped and compressed few normal renal tubules. The blastemal cells moderately differentiated to form rosettes, primitive tubules, and a glomeruloid body. Multifocally, the lumen of primitive tubules contained eosinophilic secretions with basophilic material in the center. The diagnostic criteria used were compared and differentiated with renal dysplasia, nephrogenic rest, NB in rats, and with that of the identical lesion in children.

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Section: Casesupporting

confidence: 75%

Section: Casementioning

confidence: 99%

Section: Casementioning

confidence: 99%

Section: Casementioning

confidence: 99%

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Intralobar Nephroblastematosis in a Nine-week-old Wistar Rat

Kalaiselvan¹,

Mathur²,

Pande³

et al. 2009

Toxicol Pathol

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“…Nephroblastoma is considered to be associated with its precursor lesions, the nephrogenic rest, characterized by proliferation of the nephrogenic blastemal cell 9 . Several genes are reported to be involved in nephroblastoma tumorigenesis.…”

mentioning

confidence: 99%

A case of spontaneous nephroblastoma characterized by two distinct morphologies in a Slc:CD(SD)IGS rat

et al. 2020

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We report a spontaneous case of nephroblastoma in a 26-week-old female Slc:CD(SD) rat. Macroscopically, there was a yellow mass in the left kidney that included another small yellowish-white mass. Histologically, the mass was located mainly in the cortex of the kidney. The tumor showed two distinct morphologies corresponding to the macroscopic findings: a blastemal cell dominant area (blastemal area) with primitive glomeruli and immature tubules and a columnar epithelial tubule dominant area with blastemal cell cuffing on (epithelial area). The epithelial area was located inside the blastemal area and the two morphologies were characterized by the lack of a transition region. Nephroblastoma is known to be biphasic or triphasic and showing transitional features. To our knowledge, there is no report of such nephroblastoma comprising two histologically distinct areas without transition. Therefore, the two distinct morphologies of this case with no transitional characteristic is a rare feature in nephroblastoma.

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