Nephropathy associated with heroin abuse in Caucasian patients

Faria, Maria do Sameiro

doi:10.1093/ndt/gfg369

Cited by 56 publications

(40 citation statements)

References 18 publications

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“…Furthermore, it is possible that HCV infection is a surrogate for some other factor, such as heroin use, which was not measured in our study and accounts for observed differences in renal function. However, the epidemiology of heroin-associated nephropathy has changed in recent years (48), and a study of renal biopsies in white male heroin users found that all individuals had evidence of HCV infection and the majority of renal pathologic lesions were MPGN (49). Therefore, even in individuals who may have used heroin, HCV is likely to represent an important component of renal dysfunction.…”

Section: Limitationsmentioning

confidence: 99%

Hepatitis C Virus Infection and the Prevalence of Renal Insufficiency

Dalrymple

Koepsell²,

Sampson³

et al. 2007

Clinical Journal of the American Society of Nephrology

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Background: Hepatitis C virus (HCV) is associated with pathologic changes in the kidney. However, the association between HCV and renal dysfunction is not well defined.Design, setting, participants, and measurements: This study estimated the prevalence of renal insufficiency among veterans who received care through the Veterans Affairs Puget Sound Health Care System. The study population consisted of veterans who underwent HCV antibody testing between January 1, 1999, and December 31, 2004, and had at least one primary care or medical subspecialty visit and at least one outpatient creatinine measurement within the 18 mo before antibody testing. Veterans were excluded when they had a history of chronic dialysis, creatinine >5 mg/dl, or renal transplantation. Study data were extracted from the electronic medical record. Renal insufficiency was defined as a creatinine level >1.5 mg/dl. Multivariate logistic regression was performed to estimate the risk for renal insufficiency associated with HCV. Among 25,782 eligible veterans, 1928 were HCV antibody positive and 23,854 were HCV antibody negative.Results: Although the proportion with renal insufficiency was lower for antibody-positive versus -negative veterans (4.8 versus 6.0%), after adjustment for age, race, gender, diabetes, and hypertension, HCV-positive veterans had a 40% higher odds for renal insufficiency (odds ratio 1.40; 95% confidence interval 1.11 to 1.76) as compared with HCV-negative veterans.Conclusions: HCV was associated with an increased prevalence of renal insufficiency.

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Section: Limitationsmentioning

confidence: 99%

Hepatitis C Virus Infection and the Prevalence of Renal Insufficiency

Dalrymple

Koepsell²,

Sampson³

et al. 2007

Clinical Journal of the American Society of Nephrology

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“…Renal biopsies in 19 white heroin users also demonstrated a spectrum of pathologic findings, including 13 patients with membranoproliferative glomerulonephritis (MPGN), two with chronic interstitial nephritis, two with acute proliferative glomerulonephritis, one with amyloidosis, and one with granulomatous glomerulonephritis and interstitial nephritis (119). All patients had serologic evidence of hepatitis C virus (HCV) infection, one had hepatitis B surface antigenemia, and three had HIV infection.…”

Section: Historical Perspective Of Renal Disease and Heroin Usementioning

confidence: 99%

Chronic Nephropathies of Cocaine and Heroin Abuse

Jaffe

Kimmel²

2006

Clinical Journal of the American Society of Nephrology

124

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Renal disease in cocaine and heroin users is associated with the nephrotic syndrome, acute glomerulonephritis, amyloidosis, interstitial nephritis, and rhabdomyolysis. The pathophysiologic basis of cocaine-related renal injury involves renal hemodynamic changes, glomerular matrix synthesis and degradation, and oxidative stress and induction of renal atherogenesis. Heroin is the most commonly abused opiate in the United States. Previous studies identified a spectrum of renal diseases in heroin users. The predominant renal lesion in black heroin users is focal segmental glomerulosclerosis and in white heroin users is membranoproliferative glomerulonephritis. Although the prevalence of heroin use in the United States has increased, the incidence of "heroin nephropathy" has declined. Because reports of heroin nephropathy predated the surveillance of hepatitis C virus and HIV, the varied findings might be related to the spectrum of viral illnesses that are encountered in injection drug users. Socioeconomic conditions, cultural and behavioral practices, or differences in genetic susceptibilities may be more associated with the development of nephropathy in heroin users than the drug's pharmacologic properties. Administration of cocaine in animal models results in nonspecific glomerular, interstitial, and tubular cell lesions, but there is no animal model of heroin-associated renal disease. The heterogeneity of responses that are associated with heroin is not consistent with a single or simple notion of nephropathogenesis. There are no well-designed, prospective, epidemiologic studies to assess the incidence and the prevalence of renal disease in populations of opiate users and to establish the validity of a syndrome such as heroin nephropathy. It is concluded although there is a paucity of evidence to support a heroinassociated nephropathy, the evidence from in vitro cellular and animal studies to support the existence of cocaine-induced renal changes is more convincing.

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“…La insuficiencia renal aguda se desarrolla en el 30% de los casos de rabdomiolisis. El consumo de la sustancia está implicado por la fisiopatología de la enfermedad 39,40 .…”

Section: Conclusionesunclassified

Complicaciones del uso de la heroína parenteral: artículo de revisión

Ocampo

Gómez

2017

MedUPB

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RESUMENRevisión narrativa que buscó recopilar informacion sobre complicaciones del uso de la heroína parenteral. Fueron captados artículos científicos, revisiones y casos clínicos en las bases de datos Scielo, Lilacs, Medline. La heroína es una sustancia psicoactiva y su uso tiene consecuencias adversas para la salud física y mental; las complicaciones físicas más frecuentes son infecciones por virus como el HIV, las hepatitis B y C, infecciones de piel, tuberculosis, embolias pulmonares y enfermedades renales. Otras complicaciones frecuentes son los trastornos mentales como depresión, trastornos de personalidad y el uso concomitante de otras sustancias, como el cannabis y la cocaína. Para el profesional de enfermería es importante conocer las complicaciones del uso de la heroína para planear procesos integrales y elaborar programas de reduccion de riesgos y daños derivados del uso de la sustancia. Palabras clave: heroína; abuso de sustancias por vía intravenosa; impactos en la salud. ABSTRACTThis literature review sought to collect information on complications of parenteral use of heroin. Scientific articles, reviews, and case reports were selected from Scielo, Lilacs, and Medline databases. Heroin is a psychoactive substance and its use has mental and physical health consequences; among the most common physical consequences are blood-borne infectious diseases such as HIV, hepatitis B and C, skin infections, tuberculosis, pulmonary embolism, and renal disease. Other frequent complications include mental disorders, such as depression, personality disorders, and the concomitant abuse of other substances, such as cannabis and cocaine. It is important for nurses to be aware of the complications of heroin use in order to plan comprehensive processes and develop nursing programs that reduce the risks and harm resulting from use of the substance. Keywords: heroin; substance abuse, intravenous; impacts on health. RESUMORevisão narrativa que buscou recopilar informação sobre complicações do uso da heroína parenteral. Foram captados artigos científicos, revisões e casos clínicos nas bases de dados Scielo, Lilacs, Medline. A heroína é uma substância psicoativa e seu uso tem consequências adversas para a saúde física e mental; as complicações físicas mais frequentes são infecções por vírus como o HIV, as hepatite B e C, infecções da pele, tuberculose, embolias pulmonares e doenças renais. Outras complicações frequentes são os transtornos mentais como depressão, transtornos de personalidade e o uso concomitante de outras substâncias, como a maconha e a cocaína. Para o profissional de enfermagem é importante conhecer as complicações do uso da heroína para planejar processos integrais e elaborar programas de redução de riscos e estragos derivados do uso da substância. Palavras chave: heroína; abuso de substâncias por via intravenosa; impactos na saúde.

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Nephropathy associated with heroin abuse in Caucasian patients

Cited by 56 publications

References 18 publications

Hepatitis C Virus Infection and the Prevalence of Renal Insufficiency

Hepatitis C Virus Infection and the Prevalence of Renal Insufficiency

Chronic Nephropathies of Cocaine and Heroin Abuse

Complicaciones del uso de la heroína parenteral: artículo de revisión

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