Nephropathy caused by Chinese herbs in the UK

Lord, Graham M.; Tagore, Rajat; Cook, Terry; Gower, P E; Pusey, Charles D.

doi:10.1016/s0140-6736(99)03380-2

Cited by 250 publications

(136 citation statements)

References 4 publications

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“…Vouchers provide a verifiable means to identify and distinguish these plants from one another, especially if they share the same common name. For example, vouchers were used to help identify a plant species known locally in China as 'MuTong' after patients experienced kidney failure following ingestion of Chinese herbal remedies containing this plant ( Lord et al, 1999 ). The species was later identifi ed as Aristolochia manshuriensis Kom., which is nephrotoxic and may have been inadvertently used in the herbal remedy as it shares the same common name as other nonlethal http://www.bioone.org/loi/apps (2007) used DNA from herbarium specimens to show that levels of genetic variation in the endangered orchid Anacamptis palustris (Jacq.)…”

Section: Vouchers Serve As a Tool For Identifying Locations Of A Taxonmentioning

confidence: 99%

Range dynamics and invasive tendencies in Typha latifolia and Typha angustifolia in eastern North America derived from herbarium and pollen records

Shih

Finkelstein

2008

Wetlands

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Section: Vouchers Serve As a Tool For Identifying Locations Of A Taxonmentioning

confidence: 99%

Range dynamics and invasive tendencies in Typha latifolia and Typha angustifolia in eastern North America derived from herbarium and pollen records

Shih

Finkelstein

2008

Wetlands

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“…In the UK two cases were reported of end-stage renal failure following the use of Mu Tong containing AA I and AA II. Mu Tong was consumed by one patient as a tea for 6 years and the other patient used a preparation for 2 years in a undisclosed way [47].…”

Section: Exposure Datamentioning

confidence: 99%

Enforcement of the ban on aristolochic acids in Chinese traditional herbal preparations on the Dutch market

et al. 2007

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In traditional chinese medicine several Aristolochia species are used. Aristolochia spp. contain a mixture of aristolochic acids (AAs), mainly AA I and AA II which are nephrotoxicants and carcinogens. After AA-related nephropathy (AAN) and urothelial cancer were described in female patients in Belgium following intake of AA-contaminated herbal preparations, herbs with AAs were prohibited worldwide. Confusing nomenclature can cause AA contamination of certain Chinese traditional herbal preparations (THPs). Here we report the results of investigations by the Dutch Food and Consumer Product Safety Authority (VWA) into the presence of AAs in THPs sampled on the Dutch market using a liquid-chromatography--mass spectrometry method. Between 2002 and 2006 we sampled 190 Chinese THPs using recent information on Chinese THPs potentially containing AAs. AA I was found in 25 samples up to a concentration of 1,676 mg/kg. AA II was also found in 13 of these samples up to 444 mg/kg. All 25 positive samples including Mu Tong, Fang Ji, Tian Xian Teng and Xi Xin were part of a group of 68 THPs identified as possibly containing AAs. In a worst-case scenario, use of a sample of Mu Tong with the highest AA content over a 7-day period would result in the same intake levels of AAs which significantly raised the cancer risk in the Belgian AAN cases. Our results show that contaminated THPs still can be found on the market following worldwide publicity. Therefore, it can be concluded that testing of possibly AAcontaminated THPs is still essential.

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“…Several case reports have demonstrated the nephrotoxic properties of aristolochic acid, leading to what is called "Chinese herb nephropathy." The major renal injury is extensive interstitial fibrosis with tubular atrophy and loss (79). Some speculate that aristolochic acid may also be associated with Balkan endemic nephropathy, although a definite association remains unproved.…”

Section: Aristolochic Acidmentioning

confidence: 99%

A Review of Dietary Supplement–Induced Renal Dysfunction

Gabardi

Munz²,

Ulbricht³

2007

Clinical Journal of the American Society of Nephrology

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Complementary and alternative medicine (CAM) is a multibillion-dollar industry. Almost half of the American population uses some form of CAM, with many using them in addition to prescription medications. Most patients fail to inform their health care providers of their CAM use, and physicians rarely inquire. Annually, thousands of dietary supplement-induced adverse events are reported to Poison Control Centers nationwide. CAM manufacturers are not responsible for proving safety and efficacy, because the Food and Drug Administration does not regulate them. However, concern exists surrounding the safety of CAM. A literature search using MEDLINE and EMBASE was undertaken to explore the impact of CAM on renal function. English-language studies and case reports were selected for inclusion but were limited to those that consisted of human subjects, both adult and pediatric. This review provides details on dietary supplements that have been associated with renal dysfunction and focuses on 17 dietary supplements that have been associated with direct renal injury, CAM-induced immune-mediated nephrotoxicity, nephrolithiasis, rhabdomyolysis with acute renal injury, and hepatorenal syndrome. It is concluded that it is imperative that use of dietary supplements be monitored closely in all patients. Health care practitioners must take an active role in identifying patients who are using CAM and provide appropriate patient education.

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Nephropathy caused by Chinese herbs in the UK

Cited by 250 publications

References 4 publications

Range dynamics and invasive tendencies in Typha latifolia and Typha angustifolia in eastern North America derived from herbarium and pollen records

Range dynamics and invasive tendencies in Typha latifolia and Typha angustifolia in eastern North America derived from herbarium and pollen records

Enforcement of the ban on aristolochic acids in Chinese traditional herbal preparations on the Dutch market

A Review of Dietary Supplement–Induced Renal Dysfunction

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