Nephrotoxic Metal Mixtures and Preadolescent Kidney Function

Levin-Schwartz, Yuri; Politis, Maria D.; Gennings, Chris; Tamayo‐Ortiz, Marcela; Flores, Daniel; Amarasiriwardena, Chitra; Pantic, Ivan; Tolentino, Mari Cruz; Estrada-Gutiérrez, Guadalupe; Lamadrid‐Figueroa, Héctor; Téllez-Rojo, Martha M; Baccarelli, Andrea A.; Wright, Robert O.; Sanders, Alison P.

doi:10.3390/children8080673

Cited by 7 publications

(5 citation statements)

References 47 publications

(64 reference statements)

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“…Estimated glomerular filtration rate, one of the classic markers of pediatric kidney function, has shown some moderately positive relationships with metal exposure, even when measured as a mixture. [ 85 ] Similar results in preclinical investigations demonstrated that metal mixtures (As, Cd, V, and Pb) in drinking water inhibited the initial phases of pronephros development in zebra fish embryos, which eventually resulted in poorly developed kidneys. Pronephros developmental frame is equivalent to about gestation period of 3–4 weeks in the human fetus.…”

Section: Multimetal Exposure‐associated Toxicity and Riskmentioning

confidence: 63%

Multimetal exposure: Challenges in diagnostics, prevention, and treatment

Panghal,

Thakur,

Deore

et al. 2024

J Biochem & Molecular Tox

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Extensive use of heavy metals has posed a serious concern for ecosystem and human too. Heavy metals are toxic in nature and their accumulation in human body causes serious disorders such as neurological disease, cardiac disease, gastrointestinal problems, skin disorders, reproductive disease, lungs diseases, and so on. Furthermore, heavy metals not only affect the human health but also have a negative impact on the economy. In the current review, we have elaborated the impact of heavy metal exposure on human health and socioeconomics. We have discussed the molecular mechanism involved in the heavy metal‐induced human disorders such as oxidative stress, neuroinflammation, and protein misfolding. Finally, we discussed the preventive measure and treatment strategy that could counter the negative effects of heavy metal intoxications. In conclusion, there is a substantial correlation between heavy metals and the onset and advancement of several health issues. Chelation treatment could be a useful tactic to lessen the toxic metal load and the difficulties that come with it.

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Section: Multimetal Exposure‐associated Toxicity and Riskmentioning

confidence: 63%

Multimetal exposure: Challenges in diagnostics, prevention, and treatment

Panghal,

Thakur,

Deore

et al. 2024

J Biochem & Molecular Tox

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“…In Mexico, levels of Pb, Cd, and As were measured in urine and blood from adolescents from the PROGRESS longitudinal birth cohort study. This analysis found that the metal mixture in urine and blood are associated with increased eGFR and decreased cystatin C levels and that Cd and Pb are the main contributors of the mixture effects [53]. In addition, an analysis that included Cr and Li in the tooth-matrix from children from the same cohort found that exposure to a mixture of elements during the second and third trimester of gestation was the main window of vulnerability associated with children's decreased eGFR with Li and Cr as the main contributors of the mixture effect [54].…”

Section: Discussionmentioning

confidence: 94%

Chemical Element Mixtures and Kidney Function in Mining and Non-Mining Settings in Northern Colombia

Villamizar

Medina

Flórez-Vargas

et al. 2023

IJERPH

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The exposure to chemical mixtures is a problem of concern in developing countries and it is well known that the kidney is the major target organ for toxic elements. This cross-sectional study aimed to estimate the individual and composite mixture effect of a large number of chemical elements on kidney function in gold-mining and surrounding non-mining populations in northeast Colombia. We measured concentrations of 36 chemical elements in hair as indicators of chronic exposure from 199 adult participants. We estimated the effect of exposure to mixtures of chemical elements on estimated glomerular filtration rate (eGFR) using weighted quantile sum regression (WQS). The WQS index of the mixture was associated with reduced eGFR (Coefficient −2.42; 95%CI: −4.69, −0.16) being Be, Cd, Pb, As, and Mn, the principal contributors of the toxic mixture. Mining activities and Hg concentration were not associated with decreased kidney function. Our results suggest that complex mixtures of chemical elements, mainly heavy metals, act as nephrotoxic in these populations and therefore the analysis of chemical element mixtures is a better approach to identify environmental and occupational chemical risks for kidney damage.

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“…Long-term exposure to lead has been associated with cognitive decline and dementia among the elderly [90,91]. Lead also harms the vascular, renal, central and peripheral nervous systems [81,88,89,[92][93][94].…”

Section: Human Health Risk Assessmentmentioning

confidence: 99%

Risk assessment of human exposure to lead and cadmium in tissues of Blackchin Tilapia (Sarotherodon melanotheron) from an intertidal creek in the Niger Delta region of Nigeria

Ihunwo

Ibezim-Ezeani

Wekpe

et al. 2022

Environ. Res. Commun.

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The present study investigated the risk associated with concentrations of lead and cadmium in tissues (gills, livers and muscles) of Blackchin tilapia (Sarotherodon melanotheron) from upstream and downstream regions of an intertidal creek in Rivers State, Nigeria. The trend of Cd in fish tissues and water was as follows: muscle > liver > gills > water. The concentration of Cd in fish gills was higher in downstream fish when compared to upstream fish. The mean Cdmg kg −1 in fish gills was 0.048 ± 0.015—upstream and 0.549 ± 0.152—downstream, 0.037 ± 0.030—upstream and 0.769 ± 0.100—downstream, 0.026 ± 0.015—upstream and 0.902 ± 0.118—downstream, and 0.040 ± 0.018—upstream and 0.727 ± 0.157—downstream in December, January, February and March respectively. The trend of Pb in fish tissues and water was as follows: muscle > liver > gills > water. Pb was generally higher in fish sampled downstream when compared to those sampled upstream of the creek. Fish gills in upstream fishes had Pb of 6.324 ± 0.388 mg kg−1, 5.140 ± 1.249 mg kg−1, 5.459 ± 0.471 mg kg−1 and 5.730 ± 0.859 mg kg−1 while downstream fishes had Pb 7.732 ± 0.640 mg kg−1, 9.401 ± 0.711 mg kg−1, 7.575 ± 0.624 mg kg−1 and 7.644 ± 0.637 mg kg−1 in December, January, February and March respectively. Cdfish gills < Food and Agriculture Organization (FAO) maximum permissible limit (MPL), Cdfish muscles and Cdlivers < MPL for FAO, FAO/WHO and WHO. Pbgills upstream and downstream > MPL for FAO, FAO/WHO and WHO. Pb and Cd did not indicate non-carcinogenic risks to human health owing to the consumption of fish up- and downstream. In the present study, fishes sampled upstream showed low cancer risk in adults, however, cancer risk index (CRI) indicated moderate cancer risk in children (male and female). For fishes sampled downstream, CRI indicated low risk for adults and male children, but a moderate risk for female children.

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Nephrotoxic Metal Mixtures and Preadolescent Kidney Function

Cited by 7 publications

References 47 publications

Multimetal exposure: Challenges in diagnostics, prevention, and treatment

Multimetal exposure: Challenges in diagnostics, prevention, and treatment

Chemical Element Mixtures and Kidney Function in Mining and Non-Mining Settings in Northern Colombia

Risk assessment of human exposure to lead and cadmium in tissues of Blackchin Tilapia (Sarotherodon melanotheron) from an intertidal creek in the Niger Delta region of Nigeria

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