NERDS Syndrome: An Additional Case Report

Zenarola, Patrizia; Melillo, Lorella; Bisceglia, Michele; Carotenuto, M; Lomuto, M

doi:10.1159/000246531

Cited by 6 publications

(2 citation statements)

References 9 publications

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“…NERDS is an eosinophilic disorder recently described by Butterfield and characterized by an association of nodules, eosinophilia, rheumatism, dermatitis and swelling. The cardinal features included cutaneous manifestations with prominent xerosis, recurrent urticarial eruption with angioedema associated with tissue and peripheral blood eosinophilia [10]. We consider in the differential diagnosis in our patient because of rheumatism and edema of the lips, but we exclude NERDS does not support other findings.…”

Section: Discussionmentioning

confidence: 69%

A Case of Glandular Cheilitis Presenting with Recurrent Swelling of the Lips during the Course of Rheumatoid Arthritis

Dinckal¹,

Karabulut²,

Bs³

et al. 2019

Rheumatology

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Cheilitis glandularis (CG) is a rare disorder of unknown etiology charactarized by inflamation of the minor salivary glands of the lower lip. Clinically, three variants have been described: cheilitis glandularis simplex, cheilitis glandularis suppurativa, and cheilitis glandularis apostematosa. Most cases are diagnosed as the simple form of glandular cheilitis, which is characterized by enlarged excretory ducts, induration, and enlargement of the salivary glands as well as production of a rather mucopurulent saliva. The diagnosis of CG is done with clinical and pathologic correlation. A swollen lip is common in clinical practice, but the differential diagnosis and management of the condition may be challenging. Lip swelling may be related to a local or systemic condition. We hereby report an unusual case of CG of lips in a female patient visited the deparment of Internal Medicine, Ege Univercity. She was being followed up with the diagnosis of rheumatoid arthritis and presented with recurrent swelling of the lips repeatedly. She had previously been followed up for angioedema because of recurrent swelling of the lips. The patient's laboratory tests were normal and lip biopsy was consistent with glandular cheilitis. The aim of this article is to discuss the differential diagnosis of glandular cheilitis.

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Section: Discussionmentioning

confidence: 69%

A Case of Glandular Cheilitis Presenting with Recurrent Swelling of the Lips during the Course of Rheumatoid Arthritis

Dinckal¹,

Karabulut²,

Bs³

et al. 2019

Rheumatology

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“…Both the patients had eosinophilia, elevated serum IgE levels and tissue eosinophilic infiltration. The third case as described by Zenarola et al presented with rheumatism, xerosis and periarticular nodules 10. There was associated tissue and blood eosinophilia.…”

Section: Discussionmentioning

confidence: 87%

Unravelling the NERDS syndrome

et al. 2018

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A 22-year-old man presented with symmetric polyarthritis, pruritus and deviation of angle of mouth to the right side since the last 7 years. His symptoms were persistent despite receiving ayurvedic medications and symptomatic therapy. Examination revealed dry skin, cutaneous nodules, xanthelasma, periarticular non-tender swellings, pitting oedema of hands and feet and lower motor neuron type right facial palsy. Haematological investigations revealed eosinophilia and skin biopsy had cutaneous eosinophilic infiltration. The constellation of above findings comprises the nodules, eosinophilia, rheumatism, dermatitis and swelling syndrome. It a rare syndrome with few reported cases in literature. The patient was started on oral corticosteroids which was subsequently tapered and methotrexate therapy. His polyarthritis and skin rashes resolved with therapy. He has been followed-up for 2 years and is presently asymptomatic for the last 1 year.

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