2021
DOI: 10.1080/09273948.2021.1872651
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Nerve Growth Factor Protects Retinal Ganglion Cells Related to Inhibiting Endoplasmic Reticulum Stress by Inhibiting IRE1-JNK-CHOP Signaling Pathway

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Cited by 10 publications
(7 citation statements)
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“…We hypothesized that the increase of VA in the combined group was related to the protection of RGC by mNGF. Our conjecture is also consistent with the results of previous studies [27] .…”
Section: Discussionsupporting
confidence: 94%
“…We hypothesized that the increase of VA in the combined group was related to the protection of RGC by mNGF. Our conjecture is also consistent with the results of previous studies [27] .…”
Section: Discussionsupporting
confidence: 94%
“…For example, Ye D et al [ 19 ] found that the apoptosis of RGCs was reduced by the expression inhibition of BCL-2 antagonistic protein. Lin B et al [ 34 ] reported that nerve growth factor could protect RGCs by decreasing the level of pro-apoptotic protein Bad and increasing the level of anti-apoptotic protein BCL-2. To further explore the mechanisms of anti-apoptosis modulated by indirubin, we evaluated the expression level of crucial apoptosis-related proteins (BCL-2 and BAD) in RGCs oxidative damage.…”
Section: Discussionmentioning
confidence: 99%
“…Studies on TMCs have demonstrated the involvement of the PERK-eIF2α-ATF4-CHOP cascade in glaucomatous TM, both in human and murine cells, highlighting the activation of this pathway in glaucoma [252][253][254][255]. Similarly, various studies have described the implication of the PERK-eIF2α-ATF4-CHOP pathway in RGC loss [256][257][258][259]. Recent literature has highlighted the potential of targeting the PERK-eIF2α-ATF4-CHOP pathway as a therapeutic approach to prevent CHOP-related oxidative stress and apoptosis, thereby mitigating TM structure and function loss and potentially reducing IOP elevation.…”
Section: Interplay Between Mitochondrial and Er Stress In Tmcs And Rgcsmentioning
confidence: 98%