Nerve Growth Factor Serum Levels in Patients with Acute Forms of Atopic Dermatitis

Lang, Undine E.; Piche, E.; Juenger, Michael; Jockers-Scheruebl, M.C.; Hellweg, Rainer

doi:10.1159/000051361

Cited by 5 publications

(7 citation statements)

References 14 publications

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“…In conclusion, the present study on NGF in patients with AD does confirm our pilot study [16] reporting that NGF serum levels are not a clinical marker that is positively correlated with severity of AD or the eosinophil basic protein. In addition, in patients with psoriasis, serum NGF does not suit as a clinical marker of disease activity.…”

Section: Discussionsupporting

confidence: 88%

“…Moreover, we show that at least in our clinically and immunologically well-characterized patients with AD, serum NGF is not significantly correlated with clinical severity of the disease nor with serum IgE levels. Hence, both results of an independent and larger sample of 57 patients represent a replication of our previous study including 23 patients with AD [16]. This is the first study on NGF levels that not only considers global severity of AD by SCORAD but specifically analyzes single signs of clinical severity and chronicity.…”

Section: Discussionsupporting

confidence: 67%

“…In patients with AD, increased levels of serum NGF [11, 13] but also of another neurotrophin, the brain-derived neurotrophic factor (BDNF), were reported [14, 15]. However, in a previous study, we did not find a positive relation between NGF serum levels in AD patients compared to healthy controls [16]. …”

Section: Introductionmentioning

confidence: 99%

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Clinical Relevance of Nerve Growth Factor Serum Levels in Patients with Atopic Dermatitis and Psoriasis

Schulte‐Herbrüggen

Fölster‐Holst

Elstermann

et al. 2007

Int Arch Allergy Immunol

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Background: Nerve growth factor (NGF) is known to act as a potent mediator in neuroinflammatory processes. Recent studies point to a role of NGF in the skin pathophysiology of atopic dermatitis (AD) and psoriasis. Hereby, NGF was found to interact with the major cellular components (mast cells and eosinophils) of both skin diseases. Objectives: In order to investigate NGF serum levels as a possible clinical marker of disease activity and immunological status, we determined serum NGF, eosinophil cationic protein (ECP), total IgE and score of AD (SCORAD) in 57 patients with AD as well as NGF and the psoriasis area and severity index (PASI) in 17 patients with psoriasis. Fifty healthy subjects served as controls. Methods: We used a highly sensitive improved fluorometric two-site ELISA system for serum NGF detection. IgE and ECP were measured by CAP-FEIA and radioimmunoassay. Results: We did not find a significant correlation between NGF and either ECP, total IgE, or severity of disease assessed by SCORAD. Also in patients with psoriasis, there was no significant correlation with disease activity determined by PASI. Conclusion: Even though there is increasing evidence showing NGF to be involved in the local inflammatory pathophysiology of AD within skin lesions, our findings suggest that NGF systemic serum concentration is not a suitable parameter to estimate the clinical or immunological status of AD or psoriasis patients. This result is inconsistent with some previous studies showing a positive correlation of serum NGF with AD severity, which might be, for example, due to the fact that the present results are corrected for unspecific binding.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 67%

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Clinical Relevance of Nerve Growth Factor Serum Levels in Patients with Atopic Dermatitis and Psoriasis

Schulte‐Herbrüggen

Fölster‐Holst

Elstermann

et al. 2007

Int Arch Allergy Immunol

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“…NGF levels decrease with age 9 , fluctuate due to emotional stress 10 , and increase in patients with allergic disease 22 . However, there have also been contradictory reports 23 , and a consensus has not been reached.…”

Section: Ngf Appearance In Saliva Aging and Number Of Retained Teethmentioning

confidence: 99%

“…There have been many reports on human NGF, and the average NGF concentration in human serum is 3.8 -110.4 pg/ml 9,10,22,23 .…”

Section: Ngf Appearance In Saliva Aging and Number Of Retained Teethmentioning

confidence: 99%

Nerve Growth Factor in Saliva Stimulated by Mastication

Komatsu¹,

Hasegawa²,

Honda³

et al. 2008

Oral Science International

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The aim of the present study was to measure the amount of nerve growth factor (NGF) present in saliva, and investigate the relationship with aging, gender, and number of retained teeth. The subjects were 93 healthy volunteers (35 males and 58 females) aged 18–87 years. Stimulated saliva was collected during gum chewing, and saliva secretion per minute and NGF concentration per unit volume were measured by enzyme‐linked immunosorbent assay. We found that NGF in saliva was measurable in all subjects. The mean NGF concentration in saliva was 55.70 ± 38.27 pg/ml, and no relationship was found between NGF concentration and aging, gender, and the number of retained teeth. The mean NGF amount in saliva was 84.38 ± 71.06 pg/min. The NGF amount in saliva decreased with age, especially for the group aged 70 years and older. It was higher in male than female subjects, and was significantly higher in the group without tooth loss compared to the edentulous group. In addition, regarding the relationship between the saliva flow rate per minute and NGF amount in saliva, the latter increased significantly with a rise in the former. These results indicate that the NGF amount in saliva is influenced by aging, masticatory function, and saliva amount. It is speculated that human salivary glands play an important role in the synthesis and expression of NGF.

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Nerve growth factor serum concentrations in healthy human volunteers: physiological variance and stability

Lang

Gallinat

Danker‐Hopfe

et al. 2003

Neuroscience Letters

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Nerve Growth Factor Serum Levels in Patients with Acute Forms of Atopic Dermatitis

Cited by 5 publications

References 14 publications

Clinical Relevance of Nerve Growth Factor Serum Levels in Patients with Atopic Dermatitis and Psoriasis

Clinical Relevance of Nerve Growth Factor Serum Levels in Patients with Atopic Dermatitis and Psoriasis

Nerve Growth Factor in Saliva Stimulated by Mastication

Nerve growth factor serum concentrations in healthy human volunteers: physiological variance and stability

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