Nerve Regeneration across a 2-cm Gap in the Rat Median Nerve Using a Resorbable Nerve Conduit Filled with Schwann Cells

Neuro tissue engineering of glial nerve guides and the impact of different cell types

“…SCs enhance axonal growth in vitro by one order of magnitude [27], support spinal cord repair [18] and regeneration via PNS implants [51]. In a most recent approach, we have found that poly-(TMC-CL) nerve guides support regeneration of severed rat median nerves [52] and the spinal cord [21] only if nerve guides have been pre-filled with SCs. Thus, SCs have become a preferred candidate for biohybrid implants.…”

A Prospective Randomized Study Comparing Woven Polyglycolic Acid and Autogenous Vein Conduits for Reconstruction of Digital Nerve Gaps

“…Current investigation is focusing on developing conduits that can actively enhance the migration of Schwann cells and axons during regeneration or that could stimulate regeneration over longer nerve gap lengths. 31,32 Over the past several years, there has been increased interest in decellularized nerve allografts. 33,34 Allografts may ultimately prove to be best: the convenience of an alloplast with the effectiveness of an autograft.…”

The Effect of Soluble Peptide Sequences on Neurite Extension on 2D Collagen Substrates and Within 3D Collagen Gels

“…32,35 The ability of synthetic scaffolds to support nerve regeneration would be enhanced by the characterization of peptide sequences that influence nerve extension. One method of determining active extracellular factors has been competitive inhibition, 9 which to the authors' knowledge, has not been studied extensively in 3D environments.…”