2024
DOI: 10.3390/jpm14050445
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Nerve Regeneration after a Nerve Graft in a Rat Model: The Effectiveness of Fibrin Glue

Giovanni Zabbia,
Francesca Toia,
Federico Coppola
et al.

Abstract: Background: Simulating the post-traumatic continuity defect of small human peripheral nerves, we compared the effectiveness of fibrin glue with neurorrhaphy for nerve gap restoration. Methods: In twenty-four male Wistar rats, a fifteen mm defect in one sciatic nerve only was made and immediately repaired with an inverted polarity autograft. According to the used technique, rats were divided into Group A (Control), using traditional neurorrhaphy, and Group B (Study), using fibrine glue sealing; in total, 50% of… Show more

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