Netherton′s syndrome

Kumar, Ramesh; Abhinandan, H B; Mehta, Prafull; Jain, Suresh

doi:10.4103/2319-7250.143665

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…Seven adamantyl -derived drugs are available in the market: Amantadine for use both as antiviral and antiparkinsonian drug [6]; Memantine, a NMDA-type glutamate receptors inhibitor [7], active in Alzheimer's disease; Rimantadine and Tromantadine as antiviral drugs [8]; Vildagliptin and Saxagliptin, as oral anti-diabetic drugs [9]; and Adapalene, a retinoid for topic use against acne [10] (Chart 2).…”

Section: Chartmentioning

confidence: 99%

Influence of the adamantyl moiety on the activity of biphenylacrylohydroxamic acid-based HDAC inhibitors

Cincinelli¹,

Musso²,

Giannini³

et al. 2014

European Journal of Medicinal Chemistry

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To investigate the influence of the adamantyl group on the biological properties of known HDAC inhibitors with a 4-phenylcinnamic skeleton, a series of compounds having the adamantyl moiety in the cap structure were synthesized and compared to the corresponding hydroxamic acids lacking this group. An unexpected finding was the substantial reduction of inhibitory activity toward the tested enzymes, in particular HDAC6, following the introduction of the adamantyl group. In spite of the reduced ability to function as HDAC inhibitors, the compounds containing the adamantyl moiety still retained a good efficacy as antiproliferative and proapoptotic agents. A selected compound (2c; ST3056) of this series exhibited an appreciable antitumor activity against the colon carcinoma xenograft HCT116.

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Section: Chartmentioning

confidence: 99%

Influence of the adamantyl moiety on the activity of biphenylacrylohydroxamic acid-based HDAC inhibitors

Cincinelli¹,

Musso²,

Giannini³

et al. 2014

European Journal of Medicinal Chemistry

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“…Previous studies pointed out that mast cells and basophils play significant roles in the pathogenesis of CSU. [13,14] For instance, it has been reported that the coagulation system and complement system participate in the mast cell activation in CSU patients. [15,16] C-reactive protein (CRP), encoded by the CRP gene, is greatly increased during infection, acute injury and autoimmune-related diseases.…”

Section: Introductionmentioning

confidence: 99%

C‐reactive protein (CRP) rs3093059C predicts poor mizolastine response in chronic spontaneous urticaria patients with elevated serum CRP level

Yan

Chen

Peng

et al. 2019

Experimental Dermatology

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Chronic spontaneous urticaria (CSU) is a frequent disorder with recurrent itchy wheals and/or angioedema, and nearly 35% patients respond poorly to non‐sedating H1 antihistamine treatment. CRP gene encodes the C‐reactive protein, which is involved in the pathogenesis of CSU. To investigate the impacts of CRP polymorphisms on the susceptibility and therapeutic efficacy in the South Han CSU patients, we enrolled 145 CSU patients in our study. After 4‐week non‐sedating H1 antihistamine monotherapy treatment, more than 50% reduction of the severity score is considered as effective, or else non‐effective. The CRP rs3093059T/C and rs2794521G/A genotypes of patients were determined by Sequenom MassARRAY. Functional studies including relative luciferase assay and β‐hexosaminidase assay were conducted in HEK293T cells or RBL‐2H3 cells to explore the function of variants. Forty (62.50%) CSU patients were effective when treated with mizolastine, and 55 (72.4%) patients were effective in the desloratadine group. We found that the patients carried with rs3093059TT genotype were significantly associated with good response (OR = 4.20, P = 0.015), had lower serum CRP, IL‐6 and TNF‐α levels than the CT/CC genotypes. In vitro, the rs3093059C allele exhibited significantly higher luciferase activity than wild allele (P < 0.001). From the β‐hexosaminidase assay, we observed the inhibiting degranulation effects by mizolastine and this effect is weakened when with a higher dose CRP in RBL‐2H3 cells. Our findings suggested that CSU patients carrying the rs3093059C allele may respond poorly to mizolastine with elevated serum CRP level.

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