Abstract:Most amino acids are encoded by multiple synonymous codons. For an amino acid, some of its synonymous codons are used much more rarely than others. Analyses of positions of such rare codons in protein sequences revealed that rare codons can impact co-translational protein folding and that positions of some rare codons are evolutionary conserved. Analyses of positions of rare codons in proteins' 3-dimensional structures, which are richer in biochemical information than sequences alone, might further explain the… Show more
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