Network Analysis Uncovers Gene-Regulatory Intersections Linking Juvenile Idiopathic Arthritis to Blood Cancers and Other Autoimmune Diseases
N. Pudjihartono,
D. Ho,
J. M. O'Sullivan
Abstract:Background
Juvenile idiopathic arthritis (JIA) is an inflammatory joint disease characterized by a complex genetic etiology. As JIA progresses, patients commonly develop additional comorbid conditions, including other autoimmune diseases and cancers. However, the specific gene-regulatory mechanism linking these conditions remains unknown. This study aims to elucidate the underlying gene-regulatory mechanisms that link JIA to its associated comorbidities.
Methods
A two-sample Mendelian Randomization (MR) anal… Show more
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