2024
DOI: 10.3390/ijms252312679
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Network-Based Bioinformatics Highlights Broad Importance of Human Milk Hyaluronan

Kathryn Y. Burge,
Hua Zhong,
Adam P. Wilson
et al.

Abstract: Human milk (HM) is rich in bioactive factors promoting postnatal small intestinal development and maturation of the microbiome. HM is also protective against necrotizing enterocolitis (NEC), a devastating inflammatory condition predominantly affecting preterm infants. The HM glycosaminoglycan, hyaluronan (HA), is present at high levels in colostrum and early milk. Our group has demonstrated that HA with a molecular weight of 35 kDa (HA35) promotes maturation of the murine neonatal intestine and protects agains… Show more

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