Network pharmacology and molecular docking of endogenous active metabolites in diabetic kidney disease
Xinmiao Xie,
Yanzhe Wang,
Sijia Chen
et al.
Abstract:Objectives
Network pharmacology and molecular docking were used to predict endogenous active metabolites with protective effects in diabetic kidney disease (DKD).
Methods
We utilized metabolomics to screen differentially expressed metabolites in kidney tissues of mice with type 2 DKD and predicted potential targets using relevant databases. The interaction network between endogenous active metabolites and target proteins was established by integrating differentially exp… Show more
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