Network pharmacology-based evaluation of natural compounds with paclitaxel for the treatment of metastatic breast cancer

Rathaur, Pooja; Soni, Mehul N.; Gelat, Brijesh; Rawal, Rakesh; Pandya, Himanshu; Johar, Kaid

doi:10.1016/j.taap.2021.115576

Cited by 5 publications

(3 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Accumulating evidence suggests that combination therapies have been shown to be more potent than monotherapy treatment in cancers [25][26][27]. They not only potentiate the treatment efficacy of each drug alone and/or allow the use of reduced doses of a single agent but also reduce the prospect of drug resistance [28,29]. A shred of evidence suggests that the combination of plant-derived active compounds and chemotherapeutic drugs can have significant therapeutic benefits.…”

Section: Discussionmentioning

confidence: 99%

Antitumor Effects of Ononin by Modulation of Apoptosis in Non-Small-Cell Lung Cancer through Inhibiting PI3K/Akt/mTOR Pathway

Gong

Ganesan

Xiong

et al. 2022

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Lung cancer is a leading global cause of cancer-related death in both males and females. Non-small-cell lung cancer (NSCLC) is the most commonly diagnosed cancer type that can be difficult to control with conventional chemotherapeutic and surgical approaches resulting in a poor prognosis. Paclitaxel (PTX) is a commonly used chemotherapeutic drug for NSCLC, which can cause tissue injury in healthy cells and affect the quality of life in patients with cancer. In order to treat NSCLC, alternative medications with minimal or no side effects are highly needed. Ononin is an isoflavone glycoside extracted from Astragali Radix (AR) that has various pharmacological activities. Therefore, this study investigated whether ononin inhibits NSCLC progression and promotes apoptosis synergistically with PTX both in vitro and in vivo. Antitumorigenic properties of ononin were determined by MTT assay, colony formation assay, migratory capacity, and apoptotic marker expression in A549 and HCC827 cells. The combination of ononin with PTX increased the expression of apoptotic markers and ROS generation and inhibited cell proliferation through the PI3K/Akt/mTOR signaling pathways. Furthermore, ononin prevented the translocation of NF-κB from cytosol to the nucleus. Also, we used the xenograft NSCLC mice model to confirm the in vivo antitumorigenic efficacies of ononin by reduction of CD34 and Ki67 expressions. Based on the histological analysis, the cotreatment of PTX and ononin reduced PTX-induced liver and kidney damage. Overall, our findings suggested that the therapeutic index of PTX-based chemotherapy could be improved by reducing toxicity with increasing antitumor capabilities when combined with ononin.

show abstract

Section: Discussionmentioning

confidence: 99%

Antitumor Effects of Ononin by Modulation of Apoptosis in Non-Small-Cell Lung Cancer through Inhibiting PI3K/Akt/mTOR Pathway

Gong

Ganesan

Xiong

et al. 2022

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…Gene Ontology (GO) analysis is an important method for annotating genes and determining biological properties such as cellular component (CC), molecular function (MF), and biological process (BP). The Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway enrichment analysis was used to investigate the role of DEGs in various pathways 17 .…”

Section: Methodsmentioning

confidence: 99%

“…The CAM experiments proceeded according to a previously described protocol with minor modifications 17 . Briefly, fertilized 6th-day Rhode Island red hen eggs were received from animal husbandry (Intensive poultry development block, Makarba, Ahmedabad, Gujarat, India) and incubated for 48 h at 37 °C with 60% humidity.…”

Section: Methodsmentioning

confidence: 99%

Integrated computational screening and liquid biopsy approach to uncover the role of biomarkers for oral cancer lymph node metastasis

Shaikh,

Yadav,

Bhadresha

et al. 2023

Sci Rep

View full text Add to dashboard Cite

Cancer is an abnormal, heterogeneous growth of cells with the ability to invade surrounding tissue and even distant organs. Worldwide, GLOBOCAN had an estimated 18.1 million new cases and 9.6 million death rates of cancer in 2018. Among all cancers, Oral cancer (OC) is the sixth most common cancer worldwide, and the third most common in India, the most frequent type, oral squamous cell carcinoma (OSCC), tends to spread to lymph nodes in advanced stages. Throughout the past few decades, the molecular landscape of OSCC biology has remained unknown despite breakthroughs in our understanding of the genome-scale gene expression pattern of oral cancer particularly in lymph node metastasis. Moreover, due to tissue variability in single-cohort studies, investigations on OSCC gene-expression profiles are scarce or inconsistent. The work provides a comprehensive analysis of changed expression and lays a major focus on employing a liquid biopsy base method to find new therapeutic targets and early prediction biomarkers for lymph node metastasis. Therefore, the current study combined the profile information from GSE9844, GSE30784, GSE3524, and GSE2280 cohorts to screen for differentially expressed genes, and then using gene enrichment analysis and protein–protein interaction network design, identified the possible candidate genes and pathways in lymph node metastatic patients. Additionally, the mRNA expression of discovered genes was assessed using real-time PCR, and the Human Protein Atlas database was utilized to determine the protein levels of hub genes in tumor and normal tissues. Angiogenesis was been investigated using the Chorioallentoic membrane (CAM) angiogenesis test. In a cohort of OSCC patients, fibronectin (FN1), C-X-C Motif Chemokine Ligand 8 (CXCL8), and matrix metallopeptidase 9 (MMP9) were significantly upregulated, corroborating these findings. Our identified significant gene signature showed greater serum exosome effectiveness in early detection and clinically linked with intracellular communication in the establishment of the premetastatic niche. Also, the results of the CAM test reveal that primary OC derived exosomes may have a function in angiogenesis. As a result, our study finds three potential genes that may be used as a possible biomarker for lymph node metastasis early detection and sheds light on the underlying processes of exosomes that cause a premetastatic condition.

show abstract

A comprehensive review on recent approaches for cancer drug discovery associated with artificial intelligence

Pandiyan

Wang

2022

Computers in Biology and Medicine

View full text Add to dashboard Cite

Network pharmacology-based evaluation of natural compounds with paclitaxel for the treatment of metastatic breast cancer

Cited by 5 publications

References 70 publications

Antitumor Effects of Ononin by Modulation of Apoptosis in Non-Small-Cell Lung Cancer through Inhibiting PI3K/Akt/mTOR Pathway

Antitumor Effects of Ononin by Modulation of Apoptosis in Non-Small-Cell Lung Cancer through Inhibiting PI3K/Akt/mTOR Pathway

Integrated computational screening and liquid biopsy approach to uncover the role of biomarkers for oral cancer lymph node metastasis

A comprehensive review on recent approaches for cancer drug discovery associated with artificial intelligence

Contact Info

Product

Resources

About