Network pharmacology combined with functional metabolomics discover bile acid metabolism as a promising target for mirabilite against colorectal cancer

Sun, Hui; Zhang, Honglian; Zhang, Aihua; Zhou, Xiaohang; Wang, Xijun; Han, Ying; Ge, Yan; Liu, Liang

doi:10.1039/c8ra04886j

Cited by 40 publications

(27 citation statements)

References 45 publications

(50 reference statements)

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“…Biomarkers have become an integral part of the research on diseases. [54][55][56][57][58][59] In this study, it was found that PF regulated 10 biomarkers by the metabolic pathways of phenylalanine, tyrosine and tryptophan biosynthesis, phenylalanine metabolism, and tryptophan metabolism, to achieve a certain therapeutic effect. Although the systematic metabolic analysis was used in our study, we can integrate the physiological indicators and pathological observations to improve this study.…”

Section: Discussionmentioning

confidence: 87%

Exploring the pharmacological effects and potential targets of paeoniflorin on the endometriosis of cold coagulation and blood stasis model rats by ultra-performance liquid chromatography tandem mass spectrometry with a pattern recognition approach

Xiaolan

Zhao

et al. 2019

RSC Adv.

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Section: Discussionmentioning

confidence: 87%

Exploring the pharmacological effects and potential targets of paeoniflorin on the endometriosis of cold coagulation and blood stasis model rats by ultra-performance liquid chromatography tandem mass spectrometry with a pattern recognition approach

Xiaolan

Zhao

et al. 2019

RSC Adv.

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“…[126][127][128][129] Numerous studies have also been tested, including early disease detection, treatment prediction and prognosis, monitoring treatment and recurrence testing. [130][131][132][133][134][135][136][137][138][139] Given the extreme complexity of biological mixtures, most MS analytical methods involve the use of LC, GC or CE. However, rapidly growing applications using evolving separation methods and protocols offer opportunities and challenges.…”

Section: Future Perspectivesmentioning

confidence: 99%

Metabolomics biotechnology, applications, and future trends: a systematic review

et al. 2019

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“…Gut microbiota participates in the regulation of nutrient hormone signaling processes regulated by bile acids [90].…”

Section: Regulation Of Gut Microbiota On Bile Acidmentioning

confidence: 99%

“…The relationship between bile acids and intestinal fl ora is not unidirectional. Bile acids can alter the structure of the intestinal fl ora by mediating bacterial growth and inhibiting the growth of other sensitive bacteria [90,91,125]. Taurine bile salts, a bile salt hydrolysate,can inhibit a certain dose of C. diffi cile (C. diffi cile) toxins, thereby effectively avoiding damage to colonic epithelial cells [126].…”

Section: Effect Of Bile Acid On Intestinal Fl Oramentioning

confidence: 99%

Recent advances in understanding cross-talk between Bile Acids and Gut Microbiota

Feng¹,

Zhang²,

Jin³

et al. 2018

Open J Proteom Genom

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Bile acid (BA) plays an important role in the absorption and translocation of fat and fat-soluble vitamins. In addition, it can also act as a signaling molecule to infl uence the energy metabolism of organisms, glucose metabolism, and the development of liver and intestinal diseases by activating receptor. Gut microbiota participates in the metabolism and transport of BA, which changes the BA associated with the occurrence and development of a variety of diseases. This is achieved through a variety of regulatory processes and is intrinsically linked to host physiology. In recent years, many scholars have used 16S rRNA gene sequencing in conjunction with serum, urine, and fecal metabolomics methods to study the mechanisms underlying the occurrence and development of disease associated with BA and gut microbiota, or to evaluate the protective action of drugs on the metabolic phenotype in rats with gut microbiota disorder. On the one hand, the gut microbiota regulates BA by activating receptors such as FXR, TGR5, and FGF15, and can regulate BA synthesis through enzyme reaction. In addition, gut microbiota can effectively hydrolyze bound parasites or heterogenous organisms that have been cleared by BA. On the other hand, BA can alter the composition of the gut microbiota by inhibiting the growth of bacteria in the intestine. These studies provide new ideas for further elucidating the relationship between gut microbiota and BA and treatment for related disease. Citation:Feng CC, Zhang AH, Miao JH, Sun H, Wang XJ, et al. (2018) Recent advances in understanding cross-talk between Bile Acids and Gut Microbiota. Open J Proteom Genom 3(1): 024-034.obesity, type 2 diabetes, infl ammation, liver and intestinal disease [5,11].Even if the concentration of these small molecules produced in the host blood can reach the same level as the drug, which microorganisms are clearly controlling this metabolic process to regulate the production of these secondary metabolites, and thus affecting the host still needs further research [1].At present, studies have confi rmed that the metabolism of BA is affected by the metabolism of gut microbiota that is an important factor affecting BA absorption and signaling pathways, thus acting on host metabolism, such as obesity, lipid metabolism, diabetes, liver disease, intestinal mucosal function, colon cancer and cardiovascular are related to BA metabolism and BA signal regulation [711,[12][13][14][15][16][17][18]. Therefore, this paper reviews the understanding cross-talk between bile acids and gut microbiota.

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Network pharmacology combined with functional metabolomics discover bile acid metabolism as a promising target for mirabilite against colorectal cancer

Abstract: In this study, a combination of network pharmacology and metabolomics was used to explore the mechanism by which mirabilite regulates bile acid metabolism in the treatment of colorectal cancer.

Cited by 40 publications

References 45 publications

Exploring the pharmacological effects and potential targets of paeoniflorin on the endometriosis of cold coagulation and blood stasis model rats by ultra-performance liquid chromatography tandem mass spectrometry with a pattern recognition approach

Exploring the pharmacological effects and potential targets of paeoniflorin on the endometriosis of cold coagulation and blood stasis model rats by ultra-performance liquid chromatography tandem mass spectrometry with a pattern recognition approach

Metabolomics biotechnology, applications, and future trends: a systematic review

Recent advances in understanding cross-talk between Bile Acids and Gut Microbiota

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