Network structure and enzymatic degradation of chitosan hydrogels determined by crosslinking methods

Ahn, Juhong; Ryu, Jungju; Song, Gwangho; Whang, Minji; Kim, Jungwook

doi:10.1016/j.carbpol.2019.04.055

Cited by 44 publications

(26 citation statements)

References 41 publications

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“…Chitosan hydrogels formed by step polymerization via a base-catalyzed thiol-ene reaction were termed SP. The hydrogel synthesis method is shown in Figure 7 [88]. Red and green linkages indicate inter-and intra-chain crosslinking, respectively [88].…”

Section: Crosslinking Through Ionizing Radiationmentioning

confidence: 99%

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Fundamental Concepts of Hydrogels: Synthesis, Properties, and Their Applications

et al. 2020

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In the present review, we focused on the fundamental concepts of hydrogels—classification, the polymers involved, synthesis methods, types of hydrogels, properties, and applications of the hydrogel. Hydrogels can be synthesized from natural polymers, synthetic polymers, polymerizable synthetic monomers, and a combination of natural and synthetic polymers. Synthesis of hydrogels involves physical, chemical, and hybrid bonding. The bonding is formed via different routes, such as solution casting, solution mixing, bulk polymerization, free radical mechanism, radiation method, and interpenetrating network formation. The synthesized hydrogels have significant properties, such as mechanical strength, biocompatibility, biodegradability, swellability, and stimuli sensitivity. These properties are substantial for electrochemical and biomedical applications. Furthermore, this review emphasizes flexible and self-healable hydrogels as electrolytes for energy storage and energy conversion applications. Insufficient adhesiveness (less interfacial interaction) between electrodes and electrolytes and mechanical strength pose serious challenges, such as delamination of the supercapacitors, batteries, and solar cells. Owing to smart and aqueous hydrogels, robust mechanical strength, adhesiveness, stretchability, strain sensitivity, and self-healability are the critical factors that can identify the reliability and robustness of the energy storage and conversion devices. These devices are highly efficient and convenient for smart, light-weight, foldable electronics and modern pollution-free transportation in the current decade.

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Section: Crosslinking Through Ionizing Radiationmentioning

confidence: 99%

“…Open circles represent the point at which the chain moves out of the plane. Red and green linkages indicate inter-and intra-chain crosslinking, respectively [88].…”

Section: Crosslinking Through Ionizing Radiationmentioning

confidence: 99%

Fundamental Concepts of Hydrogels: Synthesis, Properties, and Their Applications

et al. 2020

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“…4 Example of ionically cross-linked chitosan [12] Fig. 2 Structure of chitin and chitosan [12] linked using genipin [27,28], UV-irradiation [29][30][31], ionic cross-linking agents [32][33][34], chemical cross-linking agents [35][36][37][38][39][40][41]. Hydrogels have been prepared using blends of chitosan with other polymers and/or biopolymers [42][43][44][45][46][47][48][49][50][51].…”

Section: Chitosan In Cosmeticsmentioning

confidence: 99%

Biopolymers for hydrogels in cosmetics: review

Mitura

Sionkowska

Jaiswal³

2020

J Mater Sci: Mater Med

201

114

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Hydrogels are cross-linked networks of macromolecular compounds characterized by high water absorption capacity. Such materials find a wide range of biomedical applications. Several polymeric hydrogels can also be used in cosmetics. Herein, the structure, properties and selected applications of hydrogels in cosmetics are discussed in general. Detailed examples from scientific literature are also shown. In this review paper, most common biopolymers used in cosmetics are presented in detail together with issues related to skin treatment and hair conditioning. Hydrogels based on collagen, chitosan, hyaluronic acid, and other polysaccharides have been characterized. New trends in the preparation of hydrogels based on biopolymer blends as well as bigels have been shown. Moreover, biopolymer hydrogels employment in encapsulation has been mentioned.

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“…Glycidyl methacrylate-modified chitosan (CS-GMA) is one of the most studied chitosan derivatives. Its side chains have reactive vinyl double bonds, which can be cross-linked or converted into biologically active groups. − In addition, CS-GMA has the unique properties of biodegradability and biocompatibility and can stimulate the production and release of NO and TNF-α from macrophages, exhibiting great potential for biomaterials …”

Section: Introductionmentioning

confidence: 99%

Development of Inherently Antibacterial, Biodegradable, and Biologically Active Chitosan/Pseudo-Protein Hybrid Hydrogels as Biofunctional Wound Dressings

Yin

Wan

Ren

et al. 2021

ACS Appl. Mater. Interfaces

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Developing a new family of hydrogel-based wound dressings that could have a dual biofunctionality of antibacterial and biological responses is highly desirable. In this study, an inherently effective antibacterial and biodegradable hydrogel dressing without the need for impregnated antibiotics was designed, synthesized, characterized, and examined for its effect on macrophages, which initiated inflammatory activity and activated both NO and TNF-α production for the purpose of achieving a better and faster wound healing. The purposes of this research was to develop a novel family of cationic biodegradable hydrogels based on arginine-based poly(ester urea urethane) (Arg-PEUU) and glycidyl methacrylate-modified chitosan (CS-GMA) that has both inherent antibacterial and bioactive functionality as a wound healing dressing for accelerated healing of contaminated or infected wounds. These hybrid hydrogels present a well-defined three-dimensional microporous network structure and have a high water absorption ability, and their biodegradation is effectively accelerated in the presence of lysozymes. The hemolytic activity test, MTT assay, and live/dead assay of these hybrid hydrogels indicated that they had no cytotoxicity toward red blood cells, NIH-3T3 fibroblast cells, and human vascular endothelial cells, thus corroborating their cytocompatibility. Furthermore, these hybrid hydrogels could elevate the release of both produced NO and TNF-α by stimulating and activating RAW 264.7 macrophages, augmenting their antibacterial biological response. The antibacterial assay of these hybrid hydrogels demonstrated their excellent antibacterial activity without the need for impregnated antibacterial agents. Taken together, this new family of biodegradable, antibacterial, and biologically responsive hybrid hydrogels exhibits great potential as biofunctional antibacterial wound dressing candidates for wound healing.

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Network structure and enzymatic degradation of chitosan hydrogels determined by crosslinking methods

Cited by 44 publications

References 41 publications

Fundamental Concepts of Hydrogels: Synthesis, Properties, and Their Applications

Fundamental Concepts of Hydrogels: Synthesis, Properties, and Their Applications

Biopolymers for hydrogels in cosmetics: review

Development of Inherently Antibacterial, Biodegradable, and Biologically Active Chitosan/Pseudo-Protein Hybrid Hydrogels as Biofunctional Wound Dressings

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