A major advantage of head and neck sonography over other imaging methods is that the attending physician performs the examination himself/herself and can directly compare the imaging findings with other clinical and endoscopic findings. Given the "big picture," the physician is thus able to interpret the sonographic findings correctly. The first part of this article gives an exemplary overview of lesions of the skin, neck, and lymph nodes as well as the ensuing oncologic follow-up with ultrasound. In the second part the focus lies on salivary glands, paragangliomas, the esophagus, and vascular pathologies.