Neural and Cognitive Markers and Regulation of Emotion in Depression: A Mini-Review and a Short Case Report

Abstract

In the presented short clinical case of depression, the constructs of Research Domain Criteria (RDoC) of loss (negative valence systems) and cognitive control (cognitive systems) have been operationalized. It has been concluded that a normal cognitive control of emotion, requiring the functional and structural integrity of prefrontal cortex (PFC) and orbitofrontal cortex (OFC), is lacking in depression, but its amelioration can be achieved through the implementation of cognitive remediation/rehabilitation programs. A mini-review on neural and cognitive markers and regulation of emotion in depression is previously presented.

Neural bases of suicidal ideation and depression in young college students

“…Likewise, it has been reported that the amygdala and sgACC are associated with suicidal behavior, however, in a study conducted by Ballard and Zarate ( 2020 ), to test this relationship, they conducted a study with patients with major depression and found no relationship of these two regions with current suicidal thoughts. Executive functions are associated with the prefrontal cortex; for their study in the laboratory, tasks of cognitive control, working memory, and emotional decision making are used (Eduardo et al, 2017 ).…”

“…Executive functions are associated with the prefrontal cortex; for their study in the laboratory, tasks of cognitive control, working memory, and emotional decision making are used (Eduardo et al, 2017).…”