“…One primary task bearing on MS research is to unravel the neural machinery, from the perspective of circuits, cells and signal molecules, that drives or regulates MS development. In this case, pica only serves as gauge of MS attack which is triggered under the necessity of vestibular-activated pathways (upstream of DVC) that ultimately impact DVC (e. g., Arango et al, 1988 ; Balaban and Porter, 1998 ; Balaban, 2002 ; Belkacemi and Darmani, 2020 ; Catanzaro et al, 2014 ; Du Sert et al, 2012 ; Horn, 2008 ; Hornby, 2001 ; Koga et al, 1998 ; Napadow, 2013; Singh and Kuo, 2016 ; Yates et al, 1998 ; Zhang et al, 2017 ; Zhong et al, 2021 ) ( Fig. 1 ).…”