Neural correlates of working memory and compensation at different stages of cognitive impairment in Parkinson’s disease

Hattori, Takaaki; Reynolds, Richard C.; Wiggs, Edythe; Horovitz, Silvina G.; Lungu, Codrin; Chen, Gang; Yasuda, Eiji; Hallett, Mark

doi:10.1016/j.nicl.2022.103100

Cited by 10 publications

(3 citation statements)

References 68 publications

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“…However, this study had limitations which could be improved by conducting future EEG and functional MRI studies, along with behavioral paradigms, to distinguish between different models and pathways involved. Considering the impact of neuropsychological disorders such as Multiple Sclerosis, Alzheimer's disease, and Parkinson's on WM decline, which all require imaging modalities as a diagnostic step, integrating comparative analyses of imaging data with performance based tasks can help distinguishing different WM models in the future [17][18][19].…”

Section: Discussionmentioning

confidence: 99%

Resource or slot model in visual working memory: Are they different?

Hojjati,

Motahharynia,

Adibi

et al. 2024

Preprint

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SummaryThe ‘slot model’ and ‘resource model’ are two well-established theories used to explain working memory (WM) organization. With newer computational models suggesting that WM may not strictly conform to one model, this study aimed to understand the relationship between these models. By implementing correlational assessments of subject performances in two different tasks (analog recall paradigm with sequential bar presentation and delayed match-to-sample task (DMS) with checkerboard stimuli which are representative for resource and slot models, respectively), our study revealed significant correlations between WM performance (measured by DMS tasks) with recall error, precision, and sources of error (measured by sequential paradigm). Overall, the findings emphasize the importance of considering both models in understanding WM processes, shedding light on the debate between slot and resource models by demonstrating overlap in elements of both models.

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Section: Discussionmentioning

confidence: 99%

Resource or slot model in visual working memory: Are they different?

Hojjati,

Motahharynia,

Adibi

et al. 2024

Preprint

View full text Add to dashboard Cite

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“…[52][53][54] In meta-analyses of episodic memory retrieval, the LPFC consistently emerged as a core locus of activation in addition to the hippocampus. 55,56 The LPFC is involved in narrowing the retrieval scope and supporting accurate situational retrieval, 57 and participants show increased prefrontal activation 58,59 or exhibit strengthened prefrontal FC to memory retrieval networks 60 to maintain better working memory performance, suggesting a compensatory function of the LPFC in working memory. Although the lack of RAVLT scores in some HC patients in this study may have affected the statistical power, T2DM patients did not show a trend of memory impairment based on the current data.…”

Section: Discussionmentioning

confidence: 99%

Structural and functional connectivity alteration patterns of the cingulate gyrus in Type 2 diabetes

Zhang,

Huang,

Liu

et al. 2023

Ann Clin Transl Neurol

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ObjectiveWe aimed to reveal the role of structural and functional alterations of cingulate gyrus in early cognitive impairment in Type 2 diabetes mellitus (T2DM) patients.MethodsFifty‐six T2DM patients and 60 healthy controls (HCs) underwent a neuropsychological assessment and sagittal three‐dimensional T1‐weighted and resting‐state functional MRI. Differences in the cortical thickness of the cingulate cortex and the functional connectivity (FC) of the nine subregions of the cingulate gyrus and the whole brain were compared between T2DM patients and HCs. Correlation analysis was performed between cortex thickness and FC and the participants' clinical/cognitive variables.ResultsThe cortical thickness of the cingulate gyrus was not significantly different between T2DM patients and HCs. However, the T2DM patients showed significantly lower FC between the pregenual ACC (pACC) and the bilateral hippocampus, significantly higher FC between the pACC and bilateral lateral prefrontal cortex (LPFC) and left precentral gyrus, and significantly lower FC between the retrosplenial cortex (RSC) and right cerebellar Crus I. The FC between the pACC and the left hippocampus was negatively correlated with the FC between the pACC and LPFC (r = −0.306, p = 0.022).InterpretationThe pACC and the RSC show dysfunctional connectivity before the appearance of structural abnormalities in T2DM patients. Abnormal FC of the pACC with the bilateral hippocampus and LPFC may imply a neural compensatory mechanism for memory function. These findings provide valuable information and new directions for possible interventions for the T2DM‐related cognitive impairment.

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“…In particular, the changes in the dorsal striatum (caudate-putamen), because it received information directly from the dopaminergic neurons in the substantia nigra, the impairment of the activity of the dorsal striatum can lead to the dysfunction of the striatum-thalamus-cortex circuit (67)(68)(69)(70), leading to a series of clinical manifestations of motor symptoms (71)(72)(73). In addition, a large number of studies observed that in addition to motor symptoms, PD patients also suffered from cognitive disorders, such as executive ability, working memory, planning strategies and attention set switching disorders (74)(75)(76)(77). Further research has found that the cognitive impairment of PD patients was also closely related to the functional damage of striatum dopaminergic neural pathway.…”

Section: Discussionmentioning

confidence: 99%

Abnormalities of cerebral blood flow and the regional brain function in Parkinson’s disease: a systematic review and multimodal neuroimaging meta-analysis

Xie,

Yang,

Sun

et al. 2023

Front. Neurol.

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BackgroundParkinson’s disease (PD) is a neurodegenerative disease with high incidence rate. Resting state functional magnetic resonance imaging (rs-fMRI), as a widely used method for studying neurodegenerative diseases, has not yet been combined with two important indicators, amplitude low-frequency fluctuation (ALFF) and cerebral blood flow (CBF), for standardized analysis of PD.MethodsIn this study, we used seed-based d-mapping and permutation of subject images (SDM-PSI) software to investigate the changes in ALFF and CBF of PD patients. After obtaining the regions of PD with changes in ALFF or CBF, we conducted a multimodal analysis to identify brain regions where ALFF and CBF changed together or could not synchronize.ResultsThe final study included 31 eligible trials with 37 data sets. The main analysis results showed that the ALFF of the left striatum and left anterior thalamic projection decreased in PD patients, while the CBF of the right superior frontal gyrus decreased. However, the results of multimodal analysis suggested that there were no statistically significant brain regions. In addition, the decrease of ALFF in the left striatum and the decrease of CBF in the right superior frontal gyrus was correlated with the decrease in clinical cognitive scores.ConclusionPD patients had a series of spontaneous brain activity abnormalities, mainly involving brain regions related to the striatum-thalamic-cortex circuit, and related to the clinical manifestations of PD. Among them, the left striatum and right superior frontal gyrus are more closely related to cognition.Systematic review registrationhttps://www.crd.york.ac.uk/ PROSPERO (CRD42023390914).

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Neural correlates of working memory and compensation at different stages of cognitive impairment in Parkinson’s disease

Cited by 10 publications

References 68 publications

Resource or slot model in visual working memory: Are they different?

Resource or slot model in visual working memory: Are they different?

Structural and functional connectivity alteration patterns of the cingulate gyrus in Type 2 diabetes

Abnormalities of cerebral blood flow and the regional brain function in Parkinson’s disease: a systematic review and multimodal neuroimaging meta-analysis

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