Neural Oscillatory Abnormalities During Gaze Processing in Schizophrenia: Evidence of Reduced Theta Phase Consistency and Inter-areal Theta-Gamma Coupling

Grove, Tyler B.; Lasagna, Carly A; Martínez-Cancino, Ramón; Pamidighantam, Preetha; Deldin, Patricia J.; Tso, Ivy F.

doi:10.1016/j.bpsc.2020.08.013

Cited by 22 publications

(24 citation statements)

References 81 publications

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“…One of the practical advantages of the local transfer entropy is that it provides information about the dynamics of the information transfer while at the same time allowing recovery of the interaction delay δ between the time series of the system analyzed as in Equation (12) [26]:…”

Section: Information Theory and Transfer Entropymentioning

confidence: 99%

“…PAC has been observed between various frequency bands, in multiple brain regions, under different task conditions and in multiple species (see Table 1 in [3]). In addition to the widespread prevalence of PAC in healthy brain process, links have been found between PAC and a variety of neurological pathologies (e.g., in epilepsy [6], Parkinson's disease [7,8], Alzheimer's disease [9], mild cognitive impairment [10], schizophrenia [11,12], and obsessive-compulsive disorder [13]).…”

Section: Introductionmentioning

confidence: 99%

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What Can Local Transfer Entropy Tell us About Phase-amplitude Coupling in Electrophysiological Signals?

Martínez-Cancino

Delorme

Wagner

et al. 2020

Preprint

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Modulation of the amplitude of high-frequency cortical field activity locked to changes in phase of a slower brain rhythm is known as phase-amplitude coupling (PAC). The study of this phenomenon has been gaining traction in neuroscience because of several reports on its appearance in normal and pathological brain processes in humans as well as across different mammalian species. This has led to the suggestion that PAC may be an intrinsic brain process that facilitates brain inter-area communication across different spatiotemporal scales. Several methods have been proposed to measure the PAC process, but few of these enable detailed study of its time course. It appears that no studies have reported details of PAC dynamics including its possible directional delay characteristics. Here, we study and characterize the use of a novel information theoretic measure that may address this limitation: local transfer entropy. We use both simulated and actual intracranial electroencephalographic data, and in both cases we observe initial indications that local transfer entropy can be used to detect the onset and offset of modulation process periods revealed by mutual information phase-amplitude coupling (MIPAC). We review our results in the context of current theories about PAC in brain electrical activity, and discuss technical issues that must be addressed to see local transfer entropy more widely applied to PAC analysis.

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Section: Information Theory and Transfer Entropymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

What Can Local Transfer Entropy Tell us About Phase-amplitude Coupling in Electrophysiological Signals?

Martínez-Cancino

Delorme

Wagner

et al. 2020

Preprint

Self Cite

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“…To date, only a handful of studies have employed EEG functional connectivity to examine face perception in schizophrenia (see [16] for a review). Findings indicate an overwhelming reduction in connectivity across all frequencies except for the delta band [17][18][19][20][21]. Perhaps more informative for understanding social affiliative deficits, Popov and colleagues [17] examined alpha connectivity as facial expressions of happiness and fear dynamically unfolded over time.…”

Section: Introductionmentioning

confidence: 99%

An Effortful Approach to Social Affiliation in Schizophrenia: Preliminary Evidence of Increased Theta and Alpha Connectivity during a Live Social Interaction

Schiffman

et al. 2021

Brain Sciences

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People with schizophrenia often experience a profound lack of motivation for social affiliation—a facet of negative symptoms that detrimentally impairs functioning. However, the mechanisms underlying social affiliative deficits remain poorly understood, particularly under realistic social contexts. Here, we investigated subjective reports and electroencephalography (EEG) functional connectivity in schizophrenia during a live social interaction. Individuals with schizophrenia (n = 16) and healthy controls (n = 29) completed a face-to-face interaction with a confederate while having EEG recorded. Participants were randomly assigned to either a Closeness condition designed to elicit feelings of closeness through self-disclosure or a Small-Talk condition with minimal disclosure. Compared to controls, patients reported lower positive emotional experiences and feelings of closeness across conditions, but they showed comparably greater subjective affiliative responses for the Closeness (vs. Small-Talk) condition. Additionally, patients in the Closeness (vs. Small-Talk) condition displayed a global increase in connectivity in theta and alpha frequency bands that was not observed for controls. Importantly, greater theta and alpha connectivity was associated with greater subjective affiliative responding, greater negative symptoms, and lower disorganized symptoms in patients. Collectively, findings indicate that patients, because of pronounced negative symptoms, utilized a less efficient, top-down mediated strategy to process social affiliation.

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“…PAC has been observed between various frequency bands, in multiple brain regions, under different task conditions and in multiple species (see Table 1 in [ 3 ]). In addition to the widespread prevalence of PAC in healthy brain process, links have been found between PAC and a variety of neurological pathologies (e.g., in epilepsy [ 6 ], Parkinson’s disease [ 7 , 8 ], Alzheimer’s disease [ 9 ], mild cognitive impairment [ 10 ], schizophrenia [ 11 , 12 ], and obsessive-compulsive disorder [ 13 ]).…”

Section: Introductionmentioning

confidence: 99%

What Can Local Transfer Entropy Tell Us about Phase-Amplitude Coupling in Electrophysiological Signals?

Martínez-Cancino

Delorme

Wagner

et al. 2020

Entropy

Self Cite

View full text Add to dashboard Cite

Modulation of the amplitude of high-frequency cortical field activity locked to changes in the phase of a slower brain rhythm is known as phase-amplitude coupling (PAC). The study of this phenomenon has been gaining traction in neuroscience because of several reports on its appearance in normal and pathological brain processes in humans as well as across different mammalian species. This has led to the suggestion that PAC may be an intrinsic brain process that facilitates brain inter-area communication across different spatiotemporal scales. Several methods have been proposed to measure the PAC process, but few of these enable detailed study of its time course. It appears that no studies have reported details of PAC dynamics including its possible directional delay characteristic. Here, we study and characterize the use of a novel information theoretic measure that may address this limitation: local transfer entropy. We use both simulated and actual intracranial electroencephalographic data. In both cases, we observe initial indications that local transfer entropy can be used to detect the onset and offset of modulation process periods revealed by mutual information estimated phase-amplitude coupling (MIPAC). We review our results in the context of current theories about PAC in brain electrical activity, and discuss technical issues that must be addressed to see local transfer entropy more widely applied to PAC analysis. The current work sets the foundations for further use of local transfer entropy for estimating PAC process dynamics, and extends and complements our previous work on using local mutual information to compute PAC (MIPAC).

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Neural Oscillatory Abnormalities During Gaze Processing in Schizophrenia: Evidence of Reduced Theta Phase Consistency and Inter-areal Theta-Gamma Coupling

Cited by 22 publications

References 81 publications

What Can Local Transfer Entropy Tell us About Phase-amplitude Coupling in Electrophysiological Signals?

What Can Local Transfer Entropy Tell us About Phase-amplitude Coupling in Electrophysiological Signals?

An Effortful Approach to Social Affiliation in Schizophrenia: Preliminary Evidence of Increased Theta and Alpha Connectivity during a Live Social Interaction

What Can Local Transfer Entropy Tell Us about Phase-Amplitude Coupling in Electrophysiological Signals?

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