Neural Stem Cells and Nutrients: Poised Between Quiescence and Exhaustion

Cavallucci, Virve; Fidaleo, Marco; Pani, Giovambattista

doi:10.1016/j.tem.2016.06.007

Cited by 74 publications

(54 citation statements)

References 98 publications

(143 reference statements)

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“…This group comprises recently discovered neural and epidermal precursors. Studies have shown that some glial cells function as progenitors or neural stem cells (NSCs) [40], which are able to self-renew and generate the main phenotypes of the nervous system including neurons, astrocytes, and oligodendrocytes [41, 42]. Skin precursors/epidermal stem cells have been located within specific niches in the hair follicle and the epidermis.…”

Section: Properties and Hierarchy Of Stem Cellsmentioning

confidence: 99%

Unhealthy Stem Cells: When Health Conditions Upset Stem Cell Properties

Pérez

Lucas

Gálvez

2018

Cell Physiol Biochem

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The stem cell field has grown very rapidly during the last decade, offering the promise of innovative therapies to treat disease. Different stem cell populations have been isolated from various human adult tissues, mainly from bone marrow and adipose tissue, but many other body tissues harbor a stem cell population. Adult tissue stem cells are invariably found in discrete microenvironments termed niches, where they play key roles in tissue homeostasis by enabling lifelong optimization of organ form and function. Some diseases are known to strike at the stem cell population, through alterations in their specific microenvironments, making them non-viable. Furthermore, it has been shown that a transformed stem cell population could prompt the development of certain cancers. This review focuses on the potential negative aspects of a range of diseases on the activity of stem cells and how their potential use in cell therapies may be affected.

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Section: Properties and Hierarchy Of Stem Cellsmentioning

confidence: 99%

Unhealthy Stem Cells: When Health Conditions Upset Stem Cell Properties

Pérez

Lucas

Gálvez

2018

Cell Physiol Biochem

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“…Similarly, a lack of vascularization will result in the same issues in vivo. Stem cells in particular heavily rely on nutrients to regulate their transition between a quiescent and activated state, as entry into the cell cycle requires high amounts of energy (Cavallucci, Fidaleo, & Pani, 2016). As such, not only can a lack of nutrients cause starvation, but it can also influence behaviour such as proliferation and differentiation.…”

Section: Maintaining Homeostasis-nutrient Supply and Waste Removalmentioning

confidence: 99%

Oxygen and nutrient delivery in tissue engineering: Approaches to graft vascularization

Rademakers

Horvath

Blitterswijk

et al. 2019

J Tissue Eng Regen Med

124

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The field of tissue engineering is making great strides in developing replacement tissue grafts for clinical use, marked by the rapid development of novel biomaterials, their improved integration with cells, better‐directed growth and differentiation of cells, and improved three‐dimensional tissue mass culturing. One major obstacle that remains, however, is the lack of graft vascularization, which in turn renders many grafts to fail upon clinical application. With that, graft vascularization has turned into one of the holy grails of tissue engineering, and for the majority of tissues, it will be imperative to achieve adequate vascularization if tissue graft implantation is to succeed. Many different approaches have been developed to induce or augment graft vascularization, both in vitro and in vivo. In this review, we highlight the importance of vascularization in tissue engineering and outline various approaches inspired by both biology and engineering to achieve and augment graft vascularization.

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“…Because metabolic defects are also responsible for stem cell exhaustion (Ito and Ito, 2016), a balance between self-renewal and differentiation of stem cells must occur through coordination of metabolic pathways and distribution of mitochondria in order to provide lifelong tissue homeostasis. The quiescence and proliferation/commitment of neural stem cells require adequate nutritional and metabolic conditions to guarantee lifelong neurogenesis while avoiding premature exhaustion (Cavallucci et al, 2016). Accumulation of genomic damage has a negative impact on stem cell functionality through diverse mechanisms and activation of downstream signals (Behrens et al, 2014).…”

Section: Overview Of the Major Hallmarks Of Agingmentioning

confidence: 99%