Neurite Orientation Dispersion and Density Imaging of Rat Brain Microstructural Changes due to Middle Cerebral Artery Occlusion at a 3T MRI

Wang, Zhenxiong; Zhu, Wenzhen; Zhang, Shun; Shaghaghi, Mehran; Cai, Kejia

doi:10.1007/s11596-021-2332-3

Cited by 6 publications

(4 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…42 Indeed, FA in the current study was on average higher in hMSC-treated animals by day 21 (although not significantly), which also has been observed in ischemic mice treated with MSC-derived exosomes 43 by day 14. Morphological differences in rat brain tissue after stroke has been reported previously using NODDI metrics, which were correlated to histology that confirmed neuronal swelling, bending and distortions in the short-term, 44 although not with stem cell application. A suspected reason for this swelling could be inflammatory and glial infiltration into the extra-neurite space, 14 and MSC application has been reported to attenuate this type of inflammatory response.…”

Section: Correlations Between Mr and Behaviorsupporting

confidence: 74%

NODDI highlights recovery mechanisms in white and gray matter in ischemic stroke following human stem cell treatment

Bagdasarian

Yuan

Athey

et al. 2021

Magnetic Resonance in Med

View full text Add to dashboard Cite

Purpose Diffusion MRI offers insight into ischemic stroke progression in both human and rodent models. However, diffusion MRI to evaluate therapeutic application of mesenchymal stem cells is limited. Robust analytical techniques are required to identify potential physiological changes as a function of cell therapy in stroke. Here, we seek to establish Neurite Orientation Dispersion and Density Imaging (NODDI) as a feasible method in evaluating stroke evolution in response to cell‐based therapeutics. Methods Diffusion MRI data at 21.1T were acquired from 16 male rats. Rats were grouped randomly: naïve (baseline, N = 5), stroke with injections of phosphate buffered saline (N = 6), stroke with injection of 2D human mesenchymal stem cells (hMSC, N = 5). Data were acquired on days 1, 3, 7, and 21 post‐surgery. DTI and NODDI maps were generated, with regions of interest placed in the ischemic hemisphere external capsule and striatum. Diffusion parameters were compared between groups each day, and within groups across hemispheres and longitudinally. Behavioral characterizations were on days 0 (pre‐surgery), 3, 7, 14, and 21. Results The 2D hMSC preserved diffusional restriction in the external capsule compared to saline (day 1: MD, P = .4060; AD, P = .0220). NODDI indicates that hMSC may have preserved intracellular volume fractions (ICVF: day 1, P = .0086; day 3, P = .0021; day 21, P = .0383). Diffusion metrics of hMSC treated animals were comparable to naïve for the external capsule. Conclusions NODDI compliments DTI metrics, enhances interpretation of tissue outcome in ischemic stroke following hMSC application, and may be useful in evaluating or predicting therapeutic response.

show abstract

Section: Correlations Between Mr and Behaviorsupporting

confidence: 74%

NODDI highlights recovery mechanisms in white and gray matter in ischemic stroke following human stem cell treatment

Bagdasarian

Yuan

Athey

et al. 2021

Magnetic Resonance in Med

View full text Add to dashboard Cite

show abstract

“…( Sepehrband et al, 2015 , Mueller et al, 2023a ) The NDI has been histologically validated to reflect the density of axons and dendrites in the brain, and their loss in disease. ( Grussu et al, 2017 , Wang et al, 2021 ) The ODI has been similarly validated on histology, with lower ODI indicating damaged WM. ( Grussu et al, 2017 ) NODDI is an extension of conventional diffusion imaging approaches such as diffusion tensor imaging (DTI), which have shown diminished WM integrity in sensorimotor, attention, and emotion regulation networks in PNES, including in the uncinate fasciculus (UF), superior temporal gyrus, and the insula.…”

Section: Introductionmentioning

confidence: 99%

White matter microstructure and serum biomarkers of inflammation in psychogenic non-epileptic seizures

Mueller

Szaflarski

2023

NeuroImage: Clinical

View full text Add to dashboard Cite

“…Brain parenchyma voxels with higher cell density exhibit lower diffusivity due to the restrictions placed on water motion by cellular components. [8][9][10] In comparison, parenchyma voxels with a high water content (eg, due to localized edema or cell loss) exhibit high diffusivity due to less restricted movement of water molecules. By measuring the displacement of water molecules, tissue properties can be inferred.…”

Section: Introductionmentioning

confidence: 99%

“…Techniques based on diffusion MRI (dMRI) take advantage of the motion of water molecules within a voxel to derive the microstructural properties of the underlying tissue. Brain parenchyma voxels with higher cell density exhibit lower diffusivity due to the restrictions placed on water motion by cellular components 8–10 . In comparison, parenchyma voxels with a high water content (eg, due to localized edema or cell loss) exhibit high diffusivity due to less restricted movement of water molecules.…”

Section: Introductionmentioning

confidence: 99%

Repeatability of neurite orientation dispersion and density imaging in patients with traumatic brain injury

Mueller

Goodman

Nenert

et al. 2023

Journal of Neuroimaging

View full text Add to dashboard Cite

Background and PurposeThe aim of this study was to assess the repeatability of neurite orientation dispersion and density imaging in healthy controls (HCs) and traumatic brain injury (TBI).MethodsSeventeen HCs and 48 TBI patients were scanned twice over 18 weeks with diffusion imaging. Orientation dispersion (ODI), neurite density (NDI), and the fraction of isotropic diffusion (F‐ISO) were quantified in regions of interest (ROIs) from a gray matter, subcortical, and white matter atlas and compared using the coefficient of variation for repeated measures (CVrep), which quantifies the expected percent change on repeated measurement. We used a modified signed likelihood ratio test (M‐SLRT) to compare the CVrep between groups in each ROI while correcting for multiple comparisons.ResultsNDI exhibited excellent repeatability in both groups; the only group difference was found in the fusiform gyrus, where HCs exhibited better repeatability (M‐SLRT = 9.463, p = .0021). ODI also had excellent repeatability in both groups, although repeatability was significantly better in HCs in 16 cortical ROIs (p < .0022) and in the bilateral white matter and bilateral cortex (p < .0027). F‐ISO exhibited relatively poor repeatability in both groups, with few group differences.ConclusionOverall, the repeatability of the NDI, ODI, and F‐ISO metrics over an 18‐week period is acceptable for assessing the effects of behavioral or pharmacological interventions, though caution is advised when assessing F‐ISO changes over time.

show abstract

Neurite Orientation Dispersion and Density Imaging of Rat Brain Microstructural Changes due to Middle Cerebral Artery Occlusion at a 3T MRI

Cited by 6 publications

References 30 publications

NODDI highlights recovery mechanisms in white and gray matter in ischemic stroke following human stem cell treatment

NODDI highlights recovery mechanisms in white and gray matter in ischemic stroke following human stem cell treatment

White matter microstructure and serum biomarkers of inflammation in psychogenic non-epileptic seizures

Repeatability of neurite orientation dispersion and density imaging in patients with traumatic brain injury

Contact Info

Product

Resources

About