Neuro- and nephrotoxicity of subchronic cadmium chloride exposure and the potential chemoprotective effects of selenium nanoparticles

Sadek, Kadry M.; Lebda, Mohamed A.; Abouzed, Tarek K.; Nasr, Sherif; Shoukry, Moustafa

doi:10.1007/s11011-017-0053-x

Cited by 60 publications

(44 citation statements)

References 74 publications

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“…It is worth mentioning that during recent years a special attention to Se containing nanoparticles and their appliance in medicine is given [75][76][77][78][79][80]. Due to both reduced toxicity and improved targeting Se-nanoparticles are more effective in cancer treatment in comparison with other Se compounds.…”

Section: Chemotherapeutic Application Of Redox Active Se Compoundsmentioning

confidence: 99%

Selenium Anticancer Properties and Impact on Cellular Redox Status

et al. 2020

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(1) Background: In this review, we provide information published in recent years on the chemical forms, main biological functions and especially on antioxidant and prooxidant activities of selenium. The main focus is put on the impact of selenoproteins on maintaining cellular redox balance and anticancerogenic function. Moreover, we summarize data on chemotherapeutic application of redox active selenium compounds. (2) Methods: In the first section, main aspects of metabolism and redox activity of selenium compounds is reviewed. The second outlines multiple biological functions, asserted when selenium is incorporated into the structure of selenoproteins. The final section focuses on anticancer activity of selenium and chemotherapeutic application of redox active selenium compounds as well. (3) Results: optimal dietary level of selenium ensures its proper antioxidant and anticancer activity. We pay special attention to antioxidant activities of selenium compounds, especially selenoproteins, and their importance in antioxidant defence. It is worth noting, that data on selenium anticancer properties is still contraversive. Moreover, selenium compounds as chemotherapeutic agents usually are used at supranutritional doses. (4) Conclusions: Selenium play a vital role for many organism systems due to its incorporation into selenoproteins structure. Selenium possesses antioxidant activity at optimal doses, while at supranutritional doses, it displays prooxidant activity. Redox active selenium compounds can be used for cancer treatment; recently special attention is put to selenium containing nanoparticles.

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Section: Chemotherapeutic Application Of Redox Active Se Compoundsmentioning

confidence: 99%

Selenium Anticancer Properties and Impact on Cellular Redox Status

et al. 2020

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“…A protective effect of selenium was also reported against toxicity of other heavy metals, such as chromium (against chromium-induced oxidative and cellular damage in thyroid gland [ 162 ], chromium toxicity in the brain [ 163 ] and chromium-induced nephrotoxicity [ 164 ]), cadmium (the protection of jejunal epithelial cells from cadmium-induced DNA damage [ 165 ], an antagonistic effect of selenium on cadmium-induced damage of kidney [ 166 ], ameliorative effect against cadmium chloride-induced neuro- and nephrotoxicity [ 167 ]), and lead (against lead toxicity on the antioxidant system [ 168 ]), or also overabundance of iron. Selenium reduces the adverse impacts of excess iron intake.…”

Section: Biochemistry Of Seleniummentioning

confidence: 99%

A Summary of New Findings on the Biological Effects of Selenium in Selected Animal Species—A Critical Review

Hosnedlová

Kępińska

Skaličková

et al. 2017

IJMS

185

121

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Selenium is an essential trace element important for many physiological processes, especially for the functions of immune and reproductive systems, metabolism of thyroid hormones, as well as antioxidant defense. Selenium deficiency is usually manifested by an increased incidence of retention of placenta, metritis, mastitis, aborts, lowering fertility and increased susceptibility to infections. In calves, lambs and kids, the selenium deficiency demonstrates by WMD (white muscle disease), in foals and donkey foals, it is associated with incidence of WMD and yellow fat disease, and in pigs it causes VESD (vitamin E/selenium deficiency) syndrome. The prevention of these health disorders can be achieved by an adequate selenium supplementation to the diet. The review summarizes the survey of knowledge on selenium, its biological significance in the organism, the impact of its deficiency in mammalian livestock (comparison of ruminants vs. non-ruminants, herbivore vs. omnivore) and possibilities of its peroral administration. The databases employed were as follows: Web of Science, PubMed, MEDLINE and Google Scholar.

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“…Co-administration of SeNPs with cisplatin significantly improved the serum testosterone, sperm quality, and spermatogenesis and decreased cisplatin-induced free radical toxic stress and spermatic DNA damage. The chemoprotective effects of SeNPs on neurotoxicity and nephrotoxicity caused by subchronic cadmium chloride exposure were verified by Sadek et al 82 They stated that SeNPs ameliorated the adverse neurological and nephrotoxic effects partially through scavenging of free radicals, metal ion chelation, averting apoptosis, and altering the cell-protective pathways. In another study, the protective effect of SeNPs against 7,12-dimethylbenz(a)anthracene (DMBA)-induced immunotoxicity was examined.…”

mentioning

confidence: 89%

Selenium as a pleiotropic agent for medical discovery and drug delivery

Guan¹,

Yan²,

Li³

et al. 2018

IJN

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Selenium as a biologically active element lends much support to health maintenance and disease prevention. It is now presenting pleiotropic effects on therapy and drug delivery. In this study, a profiling on the physiological functions, therapeutic significances, clinical/preclinical performances, and biomedical and drug delivery applications of selenium in different modalities was carried out. Major interests focused on selenium-based nanomedicines in confronting various diseases pertaining to selenium or not, especially in antitumor and antidiabetes. Furthermore, the article exclusively discusses selenium nanoparticles featured by ameliorative functions with emphasis on their applications in medical practice and drug delivery. The state-of-the-art in medical discovery as well as research and development on selenium and nano-selenium is discussed in this review.

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Neuro- and nephrotoxicity of subchronic cadmium chloride exposure and the potential chemoprotective effects of selenium nanoparticles

Cited by 60 publications

References 74 publications

Selenium Anticancer Properties and Impact on Cellular Redox Status

Selenium Anticancer Properties and Impact on Cellular Redox Status

A Summary of New Findings on the Biological Effects of Selenium in Selected Animal Species—A Critical Review

Selenium as a pleiotropic agent for medical discovery and drug delivery

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