Neuro-dermatological association between psoriasis and depression: an immune-mediated inflammatory process validating skin-brain axis theory

Abstract

Objective Our study's motive was to recognize various immune-mediated inflammatory processes involved in the pathogenesis of depression and psoriasis and interlink between them based on inflammatory mediators. Methods A careful and comprehensive literature search was done through various databases like PubMed, Google Scholar, and EBSCO. A total of 56 studies were included in our study after careful screening. Results The immune-mediated inflammatory process was significantly associated with the pathogenesis of both depression and psoriasis. Most of the inflammatory markers involved in Psoriasis (TNF-α, IL-2, IL-6, IL-23, IL-1β, IL-10), and increased serotonin transporters (5-HTT) were also found in the pathogenesis of depression, showing the immune-inflammatory linkage between psoriasis and major depression. Based on immune chemistry, the levels of CD2 + , CD4 + , CD8 + T-lymphocytes were also found to be raised in both depression and psoriasis, validating their relationship. Hyperactivity of HPA-axis was also found another interlink between them along with reduced melatonin amount. Conclusions According to various studies, the neuro-dermatological association between psoriasis and depression is significant. Different immune markers involved in the pathogenesis of depression and psoriasis also show the bidirectional association between them. However, this association between psoriasis and depression is positively correlated, but more work is required to answer why all depressed patients fail to develop psoriasis and why all psoriatic patients fail to develop depression.

A Poly (Caprolactone)-Cellulose Nanocomposite Hydrogel for Transdermal Delivery of Hydrocortisone in Treating Psoriasis Vulgaris

“…The clinical presentations of PV include scaly itching, oedema, fatigue, burning, and erythema. In addition to the physical manifestations, this disease has also been linked with a decline in mental state, leading to suicidal thoughts and an overall deterioration in quality of life [5,6]. Current treatment interventions for PV include topical corticosteroids, phototherapy, and systemic therapies, based on the severity of the disease.…”

Reactive Oxygen Species-Responsive Gel-Based Microneedle Patches for Prolonged and Intelligent Psoriasis Management

“…The mean CD4 + /CD8 + ratio in the model group was about 2.4, which was significantly higher than that of the normal group, indicating a representative characteristic of immune disorder in the IMQinduced psoriasis model. 72 The significantly reduced CD4 + / CD8 + ratios in EGCG-HP and MTX/EGCG-HP groups compared to the model group showed that the sustained release of EGCG led to good treatment outcomes (Figure S26a). Moreover, the percentage of CD11c + dendritic cells in the model group (35.7%) was much higher than the normal group (16.4%).…”

Leptin Receptor (rs1137101) and Brain-Derived Neurotrophic Factor (rs925946) Gene Variants Are Associated with Obesity in the Early- but Not in the Late-Onset Population of Hungarian Psoriatic Patients

“…Our findings that rs925946 showed a strong association with obesity, however, supports the theory that BDNF may indeed be involved in linking obesity with psoriasis in the early-onset group of patients. Further findings—that the blood levels of BDNF were found to be reduced not only in psoriasis but also in depression, and thus may link major depression with psoriasis—call for studies to also integrate BDNF into psycho-dermatology [ 67 , 68 , 69 ]. However, the stigma of depression, which is similar to what we experience in regard to alcohol consumption [ 70 ], greatly limits the data collection for such studies.…”