Neuro‐Receptor Mediated Synapse Device Based on Crumpled MXene Ti3C2Tx Nanosheets

Wang, Kaiyang; Jia, Yunfang; Yan, Xiaobing

doi:10.1002/adfm.202104304

Cited by 21 publications

(10 citation statements)

References 46 publications

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“…[367] The in vivo monitoring can be realized by the electronic skins of MXene/ PVA crosslinked composite. [226] The artificial synapse can be achieved by neuroreceptor mediated signaling on MXene surface, [368] which demonstrates memory features. [369] The sensors can be electrically connected to Bluetooth module, which facilitates wireless data transmission to a smart phone via Apps.…”

Section: Proof-of-concept Devices and Systemsmentioning

confidence: 99%

Toward Smart Sensing by MXene

Huang

Peng

et al. 2022

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MXene is typically exfoliated by selective etching the A layer of MAX phase. [1] One example of MXene, Ti 3 C 2 F x , satisfies the stoichiometric ratio of n + 1/n, in which M, X, and T stand for transition metals, carbon or nitrogen, terminal groups at surfaces, respectively. The MXene has exhibited extraordinary electrical, [2][3][4] optical, [5] mechanical, [6][7][8] and electrochemical properties [9] since its first discovery, [10] which has become an emerging material for sensing, [11,12] communication, [13,14] energy, [15,16] environmental, [17] and healthcare applications. [18][19][20] There are many reviews existing for electrochemical energy storage, including supercapacitors, lithium ion batteries, [21][22][23] sodium ion batteries, zinc ion batteries, [24][25][26] lithium-sulfur batteries, and energy conversions, [27][28][29] includingThe Internet of Things era has promoted enormous research on sensors, communications, data fusion, and actuators. Among them, sensors are a prerequisite for acquiring the environmental information for delivering to an artificial data center to make decisions. The MXene-based sensors have aroused tremendous interest because of their extraordinary performances. In this review, the electrical, electronic, and optical properties of MXenes are first introduced. Next, the MXene-based sensors are discussed according to the sensing mechanisms such as electronic, electrochemical, and optical methods. Initially, biosensors are introduced based on chemiresistors and field-effect transistors. Besides, the wearable pressure sensor is demonstrated with piezoresistive devices. Third, the electrochemical methods include amperometry and electrochemiluminescence as examples. In addition, the optical approaches refer to surface plasmonic resonance and fluorescence resonance energy transfer. Moreover, the prospects are delivered of multimodal data fusion toward complicated human-like senses. Eventually, future opportunities for MXene research are conveyed in the new material discovery, structure design, and proof-of-concept devices.

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Section: Proof-of-concept Devices and Systemsmentioning

confidence: 99%

Toward Smart Sensing by MXene

Huang

Peng

et al. 2022

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“…Wang et al [306] devised a three-terminal (3T) acetylcholine receptor (AChR)-mediated synapse device (NR-S) from the MXene-based interface. The device has shown synaptic plasticity behavior stimulated by ACh and autoantibody (ACHR-ab) incited neuronal damage to be detected and recorded (Figure 9E).…”

Section: Neurotransmitters Biosensingmentioning

confidence: 99%

“…Figure 9. A) An electrochemical Pt/Ti 3 C 2 based transistor for the determination of Dopamine; B) amperometric response of Pt/Ti 3 C 2 /GCE towards different concentrations of the DA;[299] C) scheme showing fabrication of IL-MXene/GPE and oxidation of DA at the designed interface; D) mechanistic representation for the development of Tri-AgNP/L-Cys/Ti 3 C 2 for the recognition of 5-HT;[305] E) crumpled Ti 3 C 2 Nanosheets based neuro-receptor synapse device; F) neuro-response on AChR fabricated NR-S and bare modified by UC-Ti 3 C 2 and CN-Ti 3 C 2 respectively [306]. Figures reproduced with permission from: (A, B) ref [299],.…”

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confidence: 99%

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2D MXene‐Based Biosensing: A Review

Amara

Hussain

Ahmad

et al. 2022

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MXene emerged as decent 2D material and has been exploited for numerous applications in the last decade. The remunerations of the ideal metallic conductivity, optical absorbance, mechanical stability, higher heterogeneous electron transfer rate, and good redox capability have made MXene a potential candidate for biosensing applications. The hydrophilic nature, biocompatibility, antifouling, and anti‐toxicity properties have opened avenues for MXene to perform in vitro and in vivo analysis. In this review, the concept, operating principle, detailed mechanism, and characteristic properties are comprehensively assessed and compiled along with breakthroughs in MXene fabrication and conjugation strategies for the development of unique electrochemical and optical biosensors. Further, the current challenges are summarized and suggested future aspects. This review article is believed to shed some light on the development of MXene for biosensing and will open new opportunities for the future advanced translational application of MXene bioassays.

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“…[ 1–3 ] The synapse is a hub point in nerve fibers and has a significant role in ANS by relaying the neural signals from the receptor to the central nerve. [ 4 ] This synapse‐based neural information processing in ANS is believed to be the fundamental routine of human cognition to the external world. [ 5–7 ] With the rapid development of neurology, nanomaterials, and artificial intelligence, intense interest has been inspired to mimic the neuroconsciousness of organisms.…”

Section: Introductionmentioning

confidence: 99%

Ion Migration‐Modulated Flexible MXene Synapse for Biomimetic Multimode Afferent Nervous System: Material and Motion Cognition

Ren,

Wang,

Jia

et al. 2023

Advanced Intelligent Systems

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The biomimetic afferent nervous system (ANS) is significant for transporting external stimuli into intelligent robots; however, it is still far from bionics due to traditional multisensor and single‐cognition strategies. Herein, a flexible biomimetic ANS with multimode fuzzy perception and brain‐like cognition is developed, by fusing the ion migration‐modulated MXene synapse and machine learning (ML). First of all, the elementary perceptual ability to mimic biological neuroreceptors is demonstrated. Motion artifact in the ionic conductive elastomer (ICE) current is eliminated. Furthermore, the multimode perception and brain‐like cognition are accomplished by synaptic currents (SCs) and nine ML algorithms. Finally, the cognitions of materials, gestures, and motions are conducted by distributing the ANS devices across body joints, and with the optimal ML method, the accuracies can reach 80%, 100%, and 90%, respectively. This synapse‐based ANS may provide a new idea for developing next‐generation neuromorphic intelligent robots.

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Neuro‐Receptor Mediated Synapse Device Based on Crumpled MXene Ti₃C₂T_x Nanosheets

Cited by 21 publications

References 46 publications

Toward Smart Sensing by MXene

Toward Smart Sensing by MXene

2D MXene‐Based Biosensing: A Review

Ion Migration‐Modulated Flexible MXene Synapse for Biomimetic Multimode Afferent Nervous System: Material and Motion Cognition

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