Neuro‐SPECT: On the development and function of brain emission tomography in the Copenhagen area

Lassen, Anders; Stokely, Ernest M.; Vorstrup, Sissel; Goldman, Tomasz; Henriksen, Jens H.

doi:10.1111/cpf.12663

Cited by 4 publications

(1 citation statement)

References 103 publications

(115 reference statements)

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“…The SPECT scanner not only gave possibilities to continue CBF research but further opened for a new dimension of research possibilities. The scanner was in use for the next two decades and gave rise to hundreds of publications (Lassen et al, 2021). The SPECT scanner also allowed for the use of new isotopes for blood flow measurements such as 99m Tc-HMPAO, a radiolabelled compound that is lipophilic crossing the BBB, but thereafter rapidly transferred to a hydrophilic substance, which is trapped in the brain.…”

Section: Niels Alexander Lassen's Researchmentioning

confidence: 99%

The history of Danish neuroscience

Paulson

Schousboe

Hultborn

2023

Eur J of Neuroscience

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The history of Danish neuroscience starts with an account of impressive contributions made at the 17th century. Thomas Bartholin was the first Danish neuroscientist, and his disciple Nicolaus Steno became internationally one of the most prominent neuroscientists in this period. From the start, Danish neuroscience was linked to clinical disciplines. This continued in the 19th and first half of the 20th centuries with new initiatives linking basic neuroscience to clinical neurology and psychiatry in the same scientific environment. Subsequently, from the middle of the 20th century, basic neuroscience was developing rapidly within the preclinical university sector. Clinical neuroscience continued and was even reinforced during this period with important translational research and a close co‐operation between basic and clinical neuroscience. To distinguish ‘history’ from ‘present time’ is not easy, as many historical events continue in present time. Therefore, we decided to consider ‘History’ as new major scientific developments in Denmark, which were launched before the end of the 20th century. With this aim, scientists mentioned will have been born, with a few exceptions, no later than the early 1960s. However, we often refer to more recent publications in documenting the developments of initiatives launched before the end of the last century. In addition, several scientists have moved to Denmark after the beginning of the present century, and they certainly are contributing to the present status of Danish neuroscience—but, again, this is not the History of Danish neuroscience.

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Section: Niels Alexander Lassen's Researchmentioning

confidence: 99%

The history of Danish neuroscience

Paulson

Schousboe

Hultborn

2023

Eur J of Neuroscience

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Synthesis, physicochemical characterization and biological properties of new 5-(1H-phenanthro[9,10-d]imidazol-2-yl)-thiophene-2-carbaldehyde

Kula

Krawczyk

Kaźmierski

et al. 2022

Journal of Molecular Structure

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Evaluating the Sorption Affinity of Low Specific Activity 99Mo on Different Metal Oxide Nanoparticles

et al. 2022

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99Mo/99mTc generators are mainly produced from 99Mo of high specific activity generated from the fission of 235U. Such a method raises proliferation concerns. Alternative methods suggested the use of low specific activity (LSA) 99Mo to produce 99mTc generators. However, its applicability is limited due to the low adsorptive capacity of conventional adsorbent materials. This study attempts to investigate the effectiveness of some commercial metal oxides nanoparticles as adsorbents for LSA 99Mo. In a batch equilibration system, we studied the influence of solution pH (from 1–8), contact time, initial Mo concentration (from 50–500 mg∙L−1), and temperature (from 298–333 K). Moreover, equilibrium isotherms and thermodynamic parameters (changes in free energy ΔG0, enthalpy change ΔH0, and entropy ΔS0) were evaluated. The results showed that the optimum pH of adsorption ranges between 2 and 4, and that the equilibrium was attained within the first two minutes. In addition, the adsorption data fit well with the Freundlich isotherm model. The thermodynamic parameters prove that the adsorption of molybdate ions is spontaneous. Furthermore, some investigated adsorbents showed maximum adsorption capacity ranging from 40 ± 2 to 73 ± 1 mg Mo∙g−1. Therefore, this work demonstrates that the materials used exhibit rapid adsorption reactions with LSA 99Mo and higher capacity than conventional alumina (2–20 mg Mo∙g−1).

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Neuro‐SPECT: On the development and function of brain emission tomography in the Copenhagen area

Cited by 4 publications

References 103 publications

The history of Danish neuroscience

The history of Danish neuroscience

Synthesis, physicochemical characterization and biological properties of new 5-(1H-phenanthro[9,10-d]imidazol-2-yl)-thiophene-2-carbaldehyde

Evaluating the Sorption Affinity of Low Specific Activity 99Mo on Different Metal Oxide Nanoparticles

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