Neuroanatomy of basic cognitive function

Ashley, Mark J.; Ashley, Jessica; Ashley, Matthew J.

doi:10.1201/9781315371351-6

Cited by 3 publications

(3 citation statements)

References 1 publication

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“…This methodology could broaden the field of in situ drug synthesis for varying applications including but not limited to cancer therapeutics. [68][69][70][71][72] Furthermore, CDNI-Pro could be used for applications that involve other roles for proline beyond aldol catalysis. 73,74 Future work aims to expand the irradiation wavelengths to enable catalyst activation with visible to near IR regions for a more functionally versatile caged catalyst.…”

Section: Discussionmentioning

confidence: 99%

Caged Proline in Photoinitiated Organocatalysis

et al. 2019

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Organocatalysis is an emerging field in which small metal-free organic structures catalyze a diversity of reactions with remarkable stereoselectivity. The ability to selectively switch on such pathways upon demand has proven to be a valuable tool in biological systems. Light as a trigger provides the ultimate spatial and temporal control of activation. However, there have been limited examples of photo triggered catalytic systems. Herein, we describe the synthesis and application of a caged proline system that can initiate organocatalysis upon irradiation. The caged proline was generated using the highly efficient 4-carboxy-5,7-dinitroindolinyl (CDNI) photocleavable protecting group in a 4-step synthesis. Advantages of this system include water solubility, biocompatibility, high quantum yield for catalyst release, and responsiveness to two-photon excitation. We showed the light triggered catalysis of a crossed aldol, a Mannich, and a self-aldol condensation reaction. We also demonstrated light initiated catalysis leading to the formation of a biocide in situ, which resulted in the growth inhibition of E. coli, with as little as 3 minutes of irradiation. This technique can be broadly applied to other systems by which the formation of active forms of drugs can be catalytically assembled remotely via two-photon irradiation.

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Section: Discussionmentioning

confidence: 99%

Caged Proline in Photoinitiated Organocatalysis

et al. 2019

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“…There are more than 250 knot configurations. 69 Tera and Aberg first described knot configuration notations (Fig. 3).…”

Section: Knot Configurationmentioning

confidence: 99%

Knot Security 101: A Comprehensive Practical Review to Optimal Knot Configuration, Pulling Direction, Throw Count, and Tail Length

Bushong,

Janis

2024

Plastic and Reconstructive Surgery - Global Open

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Background: Knots are the weakest structural point in a suture line and inevitably weaken almost all suture materials. This practical review critically evaluates the factors, such as suture material properties, gauge, configuration, throw count, and tail length, that affect knot security. Methods: A PubMed search between the years 1934 and 2023 identified relevant studies that addressed factors relating to knot security. Studies that investigated knots and sutures solely used in laparoscopic and arthroscopic surgery were excluded. Knot configurations assessed were the Aberdeen, sliding, square, and surgeon’s. Results: Eighty-six articles were included in this review article and demonstrated that knot security varies greatly between suture materials and gauge. Knot security also varies by configuration, throw count, conditions, tail length, and stitch type. Throw count differs by knot configuration, with the Aberdeen knot being most secure with three throws and one to two turns compared with three to five throws for surgeon’s and square knots. The optimal tail length was 3 mm. Conclusions: This practical review demonstrates that there are significant differences in knot security based on a variety of factors. It is challenging to propose an ideal knot because most studies did not evaluate knot security using a broad variety of suture materials, gauges, and throws for each of the most common knots. Although this review article demonstrated several applicable findings, additional robust studies are needed to simplify proposals.

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“…There are now several vaccine types that are being used, in an attempt to reach herd immunity, in various countries [137]. The most successful vaccines are mRNAbased, which have an estimated 92% efficacy [138,139]. Still, there is an accumulating body of evidence of the so-called 'vaccine breakthrough' phenomenon, when SARS-CoV-2 infection occurs in persons who are fully vaccinated [140,141].…”

Section: Assessment Of Host Response By Rna-seqmentioning

confidence: 99%

Diagnostic Applications for RNA-Seq Technology and Transcriptome Analyses in Human Diseases Caused by RNA Viruses

Louis¹,

Gorzalski²,

Pandori³

2021

Applications of RNA-Seq in Biology and Medicine

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Human diseases caused by single-stranded, positive-sense RNA viruses, are among the deadliest of the 21st Century. In particular, there are two notable standouts: human immunodeficiency virus (HIV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Detection of these disease-causing viral transcripts, by next-generation RNA sequencing (RNA-Seq), represents the most immediate opportunity for advances in diagnostic, therapeutic, and preventive applicability in infectious diseases (e.g., AIDS and COVID-19). Moreover, RNA-Seq technologies add significant value to public health studies by first, providing real-time surveillance of known viral strains, and second, by the augmentation of epidemiological databases, construction of annotations and classifications of novel sequence variants. This chapter intends to recapitulate the current knowledge of HIV and SARS-CoV-2 transcriptome architecture, pathogenicity, and some features of the host immune response. Additionally, it provides an overview of recent advances in diagnostic sequencing methodologies and discusses the future challenges and prospects on the utilization of RNA-Seq technologies.

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Neuroanatomy of basic cognitive function

Cited by 3 publications

References 1 publication

Caged Proline in Photoinitiated Organocatalysis

Caged Proline in Photoinitiated Organocatalysis

Knot Security 101: A Comprehensive Practical Review to Optimal Knot Configuration, Pulling Direction, Throw Count, and Tail Length

Diagnostic Applications for RNA-Seq Technology and Transcriptome Analyses in Human Diseases Caused by RNA Viruses

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