Neurobiological Mechanisms Involved in the Pathogenesis of Alzheimer’s Disease

Mir, Fayaz Ahmad; Rizvi, Zaigham Abbas

doi:10.1007/978-981-13-9636-6_13

Cited by 5 publications

(1 citation statement)

References 181 publications

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“…These findings support the idea that amyloid-peptide-induced free-radical control may be a useful therapeutic tool for treating AD and other related oxidative stress diseases [ 112 ]. Based on the above evidence, D609 is a potent antioxidant that may help cure AD and other related oxidative stress diseases [ 108 , 110 , 113 , 114 ].…”

Section: Pharmacological Properties Of D609mentioning

confidence: 99%

Tricyclodecan-9-yl-Xanthogenate (D609): Mechanism of Action and Pharmacological Applications

Bhat

Dar

Khan

et al. 2022

IJMS

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Tricyclodecan-9-yl xanthogenate (D609) is a synthetic tricyclic compound possessing a xanthate group. This xanthogenate compound is known for its diverse pharmacological properties. Over the last three decades, many studies have reported the biological activities of D609, including antioxidant, antiapoptotic, anticholinergic, anti-tumor, anti-inflammatory, anti-viral, anti-proliferative, and neuroprotective activities. Its mechanism of action is extensively attributed to its ability to cause the competitive inhibition of phosphatidylcholine (PC)-specific phospholipase C (PC-PLC) and sphingomyelin synthase (SMS). The inhibition of PCPLC or SMS affects secondary messengers with a lipidic nature, i.e., 1,2-diacylglycerol (DAG) and ceramide. Various in vitro/in vivo studies suggest that PCPLC and SMS inhibition regulate the cell cycle, block cellular proliferation, and induce differentiation. D609 acts as a pro-inflammatory cytokine antagonist and diminishes Aβ-stimulated toxicity. PCPLC enzymatic activity essentially requires Zn2+, and D609 might act as a potential chelator of Zn2+, thereby blocking PCPLC enzymatic activity. D609 also demonstrates promising results in reducing atherosclerotic plaque formation, post-stroke cerebral infarction, and cancer progression. The present compilation provides a comprehensive mechanistic insight into D609, including its chemistry, mechanism of action, and regulation of various pharmacological activities.

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