Neurodegenerative Memory Disorders: A potential Role of Environmental Toxins

Caban‐Holt, Allison; Mattingly, Michelle; Cooper, Gregory; Schmitt, Frederick A.

doi:10.1016/j.ncl.2004.12.005

Cited by 26 publications

(11 citation statements)

References 171 publications

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“…Other metals such as iron and copper are also suspected neurotoxins [Caban-Holt et al, 2005]. However, whether these metals are also related to longterm health effects such as dementia or Alzheimer's disease is still under debate.…”

Section: Metalsmentioning

confidence: 99%

“…Due to these negative findings, aluminum is not considered a possible risk factor for dementia by many researchers [Lidsky, 2014], although some disagree with this assessment [Walton, 2014]. The effects of other metals on Alzheimer's disease have not been studied as extensively as aluminum, and less is known of their effects [Caban-Holt et al, 2005;Shcherbatykh and Carpenter, 2007;Santibanez et al, 2007;Brewer, 2012]. Copper, zinc, and iron ions have been under investigation for their role in the etiology of Alzheimer's disease.…”

Section: Metalsmentioning

confidence: 99%

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Occupational exposures and risk of dementia‐related mortality in the prospective Netherlands Cohort Study

Koeman

Schouten

Brandt

et al. 2015

American J Industrial Med

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Section: Metalsmentioning

confidence: 99%

Section: Metalsmentioning

confidence: 99%

Occupational exposures and risk of dementia‐related mortality in the prospective Netherlands Cohort Study

Koeman

Schouten

Brandt

et al. 2015

American J Industrial Med

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“…Research indicated that MCs negatively affect various human organs when exposed to it. Several organs or tissues including liver [21,22,23,24,25,26], kidney [25,26,27], nervous system [28,29,30], gastrointestinal tract [31,32,33], reproductive system [34,35] and cardiovascular [36] have been reported to be target organs for MC toxicity. This review will focus on the cardiovascular toxicity of MCs and provide some evidence of cardiovascular toxicity caused by MCs.…”

Section: Introductionmentioning

confidence: 99%

A Review of Cardiovascular Toxicity of Microcystins

Cao

Massey

Feng

et al. 2019

Toxins

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The mortality rate of cardiovascular diseases (CVD) in China is on the rise. The increasing burden of CVD in China has become a major public health problem. Cyanobacterial blooms have been recently considered a global environmental concern. Microcystins (MCs) are the secondary products of cyanobacteria metabolism and the most harmful cyanotoxin found in water bodies. Recent studies provide strong evidence of positive associations between MC exposure and cardiotoxicity, representing a threat to human cardiovascular health. This review focuses on the effects of MCs on the cardiovascular system and provides some evidence that CVD could be induced by MCs. We summarized the current knowledge of the cardiovascular toxicity of MCs, with regard to direct cardiovascular toxicity and indirect cardiovascular toxicity. Toxicity of MCs is mainly governed by the increasing level of reactive oxygen species (ROS), oxidative stress in mitochondria and endoplasmic reticulum, the inhibition activities of serine/threonine protein phosphatase 1 (PP1) and 2A (PP2A) and the destruction of cytoskeletons, which finally induce the occurrence of CVD. To protect human health from the threat of MCs, this paper also puts forward some directions for further research.

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“…Aluminum (AI) exposure is known to be neurotoxic (1)(2). Al is considered to be an etiological factor in the development of several neurodegenerative disorders, includingAlzheimer's disease (3)(4), dialysis syndrome (5), Parkinson's disease (6)(7) and amyotrophic lateral sclerosis (8).…”

mentioning

confidence: 99%

Aluminum Impairs Rat Neural Cell Mitochondria In Vitro

Niu

Qiao

Zhang

et al. 2005

Int J Immunopathol Pharmacol

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Exposure to aluminum has been reported to lead to neurotoxicity. Mitochondria are important organelles involved in maintaining cell function. This study investigates the effect of aluminum on mitochondria in rat neural cells. The ultrastructure of mitochondria was observed, and the cell death rate (CDR), reactive oxygen species (ROS), mitochondrial membrane potential (MMP) and 3-[4,5demethyl-2-thiazalyl]-2,-5diphenyl-2H-tetrazolium bromide (MTT) were measured to investigate the effect of aluminum on the mitochondrial structure and its function in neural cells. Results observed from the mitochondrial ultrastructure show that aluminum may impair the mitochondrial membrane and cristae. Increased CDR, enhanced ROS, decreased MMP, and decreased enzyme activity in mitochondria were observed in the AI-exposed neurons (100 -500 ILM). The present study demonstrates that alteration in the mitochondrial structure and function plays an important role in neurotoxic mechanisms induced by aluminum.

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Neurodegenerative Memory Disorders: A potential Role of Environmental Toxins

Cited by 26 publications

References 171 publications

Occupational exposures and risk of dementia‐related mortality in the prospective Netherlands Cohort Study

Occupational exposures and risk of dementia‐related mortality in the prospective Netherlands Cohort Study

A Review of Cardiovascular Toxicity of Microcystins

Aluminum Impairs Rat Neural Cell Mitochondria In Vitro

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