Neurodevelopmental functioning of infants with untreated single-suture craniosynostosis during early infancy

Costa, Annette C Da; Anderson, Vicki; Savarirayan, Ravi; Wrennall, Jacquie; Chong, David; Holmes, Anthony D.; Greensmith, Andrew; Meara, John G.

doi:10.1007/s00381-011-1660-1

Cited by 68 publications

(55 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This rate is consistent with findings of several studies that examined developmental attainment, learning disability, and speech and language abnormalities in isolated SC. 7,8,13,14,33,44,46 Although, in 1982, Renier et al 41 found that raised ICP was correlated with lower IQ, more recent studies 6,23,34 have failed to confirm the relationship between elevated ICP and neurocognitive outcomes in SC or other single-suture craniosynostosis. The lack of a correlation between developmental delay and raised ICP found in the present study supports the hypothesis that there is no simple causal relationship between ICP and neurocognitive anomalies found in SC.…”

mentioning

confidence: 99%

The preoperative incidence of raised intracranial pressure in nonsyndromic sagittal craniosynostosis is underestimated in the literature

Wall¹,

Thomas²,

Johnson³

et al. 2014

PED

View full text Add to dashboard Cite

Object The presence of raised intracranial pressure (ICP) in untreated nonsyndromic, isolated sagittal craniosynostosis (SC) is an important functional indication for surgery. Methods A retrospective review was performed of all 284 patients presenting with SC to the Oxford Craniofacial Unit between 1995 and 2010. Results Intraparenchymal ICP monitoring was performed in 39 children following a standard unit protocol. Monitoring of ICP was offered for all patients in whom nonoperative management was considered on the basis of minimal deformity or in cases in which parents were reluctant to agree to corrective surgery. These patients presented at an older age than the rest of the cohort (mean age 56 months), with marked scaphocephaly (16/39, 41%), mild scaphocephaly (11, 28%), or no scaphocephalic deformity (12, 31%). Raised ICP was found in 17 (44%) patients, with no significant difference in its incidence among the 3 different deformity types. Raised ICP was not predicted by the presence of symptoms of ICP or developmental delay or by ophthalmological or radiological findings. Conclusions The incidence of raised ICP in SC reported here is greater than that previously published in the literature. The lack of a reliable noninvasive method to identify individuals with elevated ICP in SC mandates consideration of intraparenchymal ICP monitoring in all patients for whom nonoperative management is contemplated.

show abstract

mentioning

confidence: 99%

The preoperative incidence of raised intracranial pressure in nonsyndromic sagittal craniosynostosis is underestimated in the literature

Wall¹,

Thomas²,

Johnson³

et al. 2014

PED

View full text Add to dashboard Cite

show abstract

“…Es relevante mencionar que la mayoría de los estudios que mencionan deficiencias en niños con craneosinostosis carecen de grupo control (e.g [25][26][27][28][29] ), sólo son referidos a normas, por lo que sería importante conocer si los déficits encontrados persisten cuando se compara el desempeño con un grupo control pareado.…”

Section: Del Nacimiento a Los 3 Años De Edadunclassified

“…Por su parte, Da Costa et al 26 mencionan que los índices mental y motor de niños con craneosinostosis son más bajos que lo esperado por el grupo normativo, aunque las puntuaciones aún caen dentro de los rangos normales; en sentido opuesto, Kapp-Simons et al 28 encontraron que el 16% y el 38% de su muestra obtuvo puntuaciones por debajo de una desviación estándar en el índice mental y psicomotor. Speltz et al 31 en una comparación con un grupo control encontraron diferencias estadísticamente significativas en los índices que evalúan las Escalas Bayley.…”

Section: Del Nacimiento a Los 3 Años De Edadunclassified

“…Speltz et al 31 en una comparación con un grupo control encontraron diferencias estadísticamente significativas en los índices que evalúan las Escalas Bayley. También se ha mencionado que esta población tiene 2,2 veces más riesgo de presentar retraso psicomotor 26 . Los detalles de las investigaciones que tienen evaluaciones prequirúrgicas se resumen en la Tabla 1.…”

Section: Del Nacimiento a Los 3 Años De Edadunclassified

See 1 more Smart Citation

Una revisión de la literatura acerca de las características neuropsicológicas de niños con craneosinostosis simple en diferentes edades

Moreno

et al. 2017

Rev. chil. neuro-psiquiatr.

View full text Add to dashboard Cite

“…Similar findings have been reported in a well-designed study of Australian infants who were followed with similar developmental measures. 14 A key question is whether these delays persist into the school-age years and manifest as learning disabilities or other problems in need of intervention. 15 Few neurodevelopmental studies have focused on children with SSC beyond age 3, [16][17][18][19][20] and most of these studies have lacked control groups 17,19,20 or used methods other than testing to estimate developmental progress.…”

mentioning

confidence: 99%

Intellectual and Academic Functioning of School-Age Children With Single-Suture Craniosynostosis

2015

PEDIATRICS

View full text Add to dashboard Cite

We compared the developmental status of school-age children with single-suture craniosynostosis (case group) and unaffected children (control group). Within the case group we compared the performance of children distinguished by location of suture fusion (sagittal, metopic, unicoronal, lambdoid). METHODS:We administered standardized tests of intelligence, reading, spelling, and math to 182 case participants and 183 control participants. This sample represented 70% of those tested during infancy before case participants had corrective surgery. RESULTS:After adjustment for demographics, case participants' average scores were lower than those of control participants on all measures. The largest observed differences were in Full-Scale IQ and math computation, where case participants' adjusted mean scores were 2.5 to 4 points lower than those of control participants (Ps ranged from .002 to .09). Adjusted mean case-control differences on other measures of achievement were modest, although case deficits became more pronounced after adjustment for participation in developmental interventions. Among case participants, 58% had no discernible learning problem (score ,25th percentile on a standardized achievement test). Children with metopic, unicoronal, and lambdoid synostosis tended to score lower on most measures than did children with sagittal fusions (Ps ranged from ,.001 to .82). CONCLUSIONS:The developmental delays observed among infants with single-suture craniosynostosis are partially evident at school age, as manifested by lower average scores than those of control participants on measures of IQ and math. However, case participants' average scores were only slightly lower than those of control participants on reading and spelling measures, and the frequency of specific learning problems was comparable. Among case participants, those with unicoronal and lambdoid fusions appear to be the most neurodevelopmentally vulnerable.

show abstract

Neurodevelopmental functioning of infants with untreated single-suture craniosynostosis during early infancy

Abstract: Untreated SSC is associated with an increased incidence of developmental delay during early infancy, with motor skills appearing the most vulnerable to impairment during this developmental phase.

Cited by 68 publications

References 45 publications

The preoperative incidence of raised intracranial pressure in nonsyndromic sagittal craniosynostosis is underestimated in the literature

The preoperative incidence of raised intracranial pressure in nonsyndromic sagittal craniosynostosis is underestimated in the literature

Una revisión de la literatura acerca de las características neuropsicológicas de niños con craneosinostosis simple en diferentes edades

Intellectual and Academic Functioning of School-Age Children With Single-Suture Craniosynostosis

Contact Info

Product

Resources

About