Neurodevelopmental outcome of preterm twins at 5 years of age

Ylijoki, Milla; Haataja, Leena; Lind, Annika; Ekholm, Eeva; Lehtonen, Liisa

doi:10.1038/s41390-019-0688-x

Cited by 8 publications

(9 citation statements)

References 37 publications

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“…The area most at risk of delay is language. Twins had cognitive and neuropsychological outcomes that were otherwise comparable with singletons, but they had a slightly lower verbal intelligence quotient [53], which is consistent with our results.…”

Section: Discussionsupporting

confidence: 90%

Association of perinatal factors with suspected developmental delay in urban children aged 1–36 months - a large-scale cross-sectional study in China

You

Shi²,

Jin

et al. 2023

BMC Pediatr

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Background Studies on perinatal risk factors and the developmental delay of children have been inconclusive and few studies have assessed the association between infants and toddlers’ body mass index (BMI) and developmental outcomes. Methods We conducted a cross-sectional study of children aged 1—36 months who had a routine physical examination in the child health departments of hospitals from March 2018 to November 2021 in 16 provinces, 4 autonomous regions and 2 municipalities directly under the central government by using the Infant Toddler Growth Development Screening Test (ITGDST). Normal children were defined as those with scores ≥ mean – 2 standard deviations (SD), while children with developmental delay were those with scores < mean—2SD in terms of overall development, gross motor, fine motor and language development. Binary logistic regression was used to analyze the risk factors of gross motor, fine motor, language and overall neurodevelopment. Results After removing some provinces with a small sample size and children with incomplete data, 178,235 children with 12 complete variables were included in the final analysis. The rate of overall developmental delay was 4.5%, while 12.5% of children had at least one developmental delay aspect. Boys, parity, advanced maternal age, multiple birth, cesarean section, neonatal injury, family heredity history, microcephaly, abnormal BMI at birth and at physical examination after controlling the confounding of other factors had a significant effect on development delay (overall neurodevelopment, gross motor, fine motor or language development). Per capita gross domestic product was a protective factor for the children’s neuropsychological development. Conclusions This study reveals significant associations of perinatal factors and BMI with developmental delay in the Chinese children aged 1–36 months, which may be crucial for early intervention.

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Section: Discussionsupporting

confidence: 90%

Association of perinatal factors with suspected developmental delay in urban children aged 1–36 months - a large-scale cross-sectional study in China

You

Shi²,

Jin

et al. 2023

BMC Pediatr

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“…In this multicenter cohort of preterm infants, we found that histopathologic chorioamnionitis was not associated with IVH or punctate WMI among preterm neonates. Although some studies have found an association between IVH and chorioamnionitis, our data are consistent with most studies reporting no association (for review, see Ylijoki et al 8 ). Our finding that histopathologic chorioamnionitis was not associated with WMI is consistent with a previous analysis of the Vancouver subset of our study cohort, which showed no association with punctate WMI among preterm newborns.…”

Section: Chorioamnionitis and Perinatal Brain Injurysupporting

confidence: 92%

“…Most of these studies have focused on intraventricular hemorrhage (IVH) and cystic periventricular leukomalacia. Although individual studies have not consistently detected associations between chorioamnionitis and IVH or cystic periventricular leukomalacia (for review, see Chau et al 4 and Ylijoki et al 8 ), when pooled in a metaanalysis, chorioamnionitis was an independent risk factor for cystic periventricular leukomalacia. 9 Because the incidence of cystic periventricular leukomalacia has greatly decreased during the past decades concurrent with improvements in neonatal intensive care, punctate white matter injury (WMI) is increasingly recognized as the most prevalent pattern of brain injury among preterm neonates.…”

mentioning

confidence: 99%

Association of Histologic Chorioamnionitis With Perinatal Brain Injury and Early Childhood Neurodevelopmental Outcomes Among Preterm Neonates

Bierstone

Wagenaar

Gano

et al. 2018

Obstetrical &Amp; Gynecological Survey

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IMPORTANCE Understanding the role of chorioamnionitis, a major factor leading to preterm birth, in the pathogenesis of neonatal brain injury and adverse neurodevelopmental outcomes may help in identifying potentially modifiable perinatal variables affecting brain health and outcomes among children born preterm. OBJECTIVE To evaluate whether histologic chorioamnionitis among neonates born very preterm is associated with intraventricular hemorrhage (IVH) and punctate white matter injury (WMI) or with adverse neurodevelopmental outcomes during early childhood.

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“…Notably, the disadvantages experienced by twins are mainly attributable to the risk associated with shorter gestational age and poor foetal growth ( 18 ). Recent studies ( 19 , 20 ) have compared the neurodevelopmental outcomes of preterm multiples and preterm singletons and found no differences at a general level while a slightly lower mean score was observed for the locomotor and personal-social subscales ( 19 ) and for the verbal intelligence quotient ( 20 ).…”

Section: Introductionmentioning

confidence: 99%

“…Interestingly, even in the absence of TTTS, MC twins, especially those born prematurely, seem to be at higher risk of morbidity than preterm dichorionic (DC) twins ( 26 ). Several studies have investigated the association between chorionicity and neurodevelopmental outcome, but the findings are controversial ( 16 , 20 ).…”

Section: Introductionmentioning

confidence: 99%

To be born twin: effects on long-term neurodevelopment of very preterm infants—a cohort study

Fontana,

Schiavolin,

Ardemani

et al. 2023

Front. Pediatr.

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ObjectiveTo examine the effect of twin birth on long-term neurodevelopmental outcomes in a cohort of Italian preterm infants with very low birth weight.Study designWe performed a retrospective cohort study on children born in a tertiary care centre. We included children born between 1 January 2007 and 31 December 2013 with a gestational age (GA) of ≤32 weeks and birth weight of <1,500 g. The infants born from twin pregnancies complicated by twin-to-twin transfusion syndrome and from higher-order multiple pregnancies were excluded. The children were evaluated both at 2 years corrected age and 5 years chronological age with Griffiths mental development scales revised (GMDS-R). The linear mixed effects models were used to study the effect of being a twin vs. being a singleton on GMDS-R scores, adjusting for GA, being born small for gestational age, sex, length of NICU stay, socio-economic status, and comorbidity score (CS) calculated as the sum of the weights associated with each of the major morbidities of the infants.ResultsA total of 301 children were included in the study, of which 189 (62.8%) were singletons and 112 (37.2%) were twins; 23 out of 112 twins were monochorionic (MC). No statistically significant differences were observed between twins and singletons in terms of mean general quotient and subscales at both 2 and 5 years. No effect of chorionicity was found when comparing scores of MC and dichorionic twins vs. singletons; however, after adjusting for the CS, the MC twins showed lower scores in the hearing and language and performance subscales at 5 years.ConclusionOverall, in our cohort of children born very preterm, twin infants were not at higher risk of neurodevelopmental impairment compared with singletons at pre-school age.

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Neurodevelopmental outcome of preterm twins at 5 years of age

Cited by 8 publications

References 37 publications

Association of perinatal factors with suspected developmental delay in urban children aged 1–36 months - a large-scale cross-sectional study in China

Association of perinatal factors with suspected developmental delay in urban children aged 1–36 months - a large-scale cross-sectional study in China

Association of Histologic Chorioamnionitis With Perinatal Brain Injury and Early Childhood Neurodevelopmental Outcomes Among Preterm Neonates

To be born twin: effects on long-term neurodevelopment of very preterm infants—a cohort study

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