Neuroendocrine and immune pathways from pre- and perinatal stress to substance abuse

Horn, Sarah R.; Roos, Leslie E.; Berkman, Elliot T.; Fisher, Philip A.

doi:10.1016/j.ynstr.2018.09.004

Cited by 15 publications

(13 citation statements)

References 154 publications

(195 reference statements)

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“…Thus, findings reported in the literature may be completely confounded by the developmental influences highlighted herein (e.g., genetic, prenatal, parenting, and earlier emotional/behavioral problems). Cortisol reactivity, in particular, is typically conceptualized as a mechanism for the development of substance use (Horn, Roos, Berkman& Fisher 2018). As such, several studies have assessed whether cortisol reactivity could be a mediating mechanism implicated in developmental pathways to substance use or related phenotypes (e.g., externalizing problems).…”

Section: Developmental Pathways That Include Genetic Prenatal Parenting and Emotional/ Behavioral Riskmentioning

confidence: 99%

Developmental Pathways from Genetic, Prenatal, Parenting and Emotional/Behavioral Risk to Cortisol Reactivity and Adolescent Substance Use: A TRAILS Study

Marceau

Brick

Knopik

et al. 2019

J Youth Adolescence

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Cortisol reactivity is a frequently studied biomarker of substance use, though infrequently examined in adolescence. However, past research provides evidence that multiple developmental influences, including genetics and both prenatal and postnatal environmental influences, contribute both to cortisol reactivity and adolescent substance use. The aim of this study was to assess the impact of these earlier developmental influences on cortisol reactivity to a social stress challenge and adolescent substance use (smoking, alcohol, and marijuana use frequency assessed at age 16 years), using data from the TRacking Adolescents' Individual Lives Survey (TRAILS; N = 2,230 adolescents, 51% female). Developmental pathways included polygenic risk, prenatal stress, warm parenting (age 11), and internalizing and externalizing problems (intercepts and change from 11-16 years). Cortisol reactivity was associated with smoking but not alcohol or marijuana use. Externalizing problems were the stronger predictor of adolescent substance use, but internalizing problems also had an important role. Prenatal stress and middle childhood parenting operated via Terms of use and reuse: academic research for non-commercial purposes, see here for full terms.

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Section: Developmental Pathways That Include Genetic Prenatal Parenting and Emotional/ Behavioral Riskmentioning

confidence: 99%

Developmental Pathways from Genetic, Prenatal, Parenting and Emotional/Behavioral Risk to Cortisol Reactivity and Adolescent Substance Use: A TRAILS Study

Marceau

Brick

Knopik

et al. 2019

J Youth Adolescence

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“…Most studies focus on the relationship between stress during pregnancy and the HPA axis in children with fatal anxiety (18). Epigenetic changes such as DNA methylation influence gene expression and suppression.…”

Section: The Effect Of Prenatal Stressmentioning

confidence: 99%

The First 1000 Days of Life and the Risk of Future Drug Consumption

Mirzaei

Oroomiei

Nakhaee

2022

Int J High Risk Behav Addict

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Context: The first 1000 days of life last from the beginning of pregnancy to the age of two, a unique step that shapes the basis for a person’s health over their lifetime. Numerous studies have indicated the relationship between one’s first 1000 days of life and the consequent adverse outcomes in adulthood. However, to the extent that we have reviewed it, not a single study has shown the relationship between various aspects of an individual’s first 1000 days of life and the probability of drug consumption in adult life. Hence, the primary purpose of this narrative review was to understand the role of the first 1000 days of life on vulnerability to drug abuse later in life. Methods: This article is a narrative review that has identified the role of the first 1000 days of life on susceptibility to substance abuse later in life. The articles were extracted from valid databases, including PubMed, Scopus, Science Direct, Web of Science, and Embase. Results: Various significant research has pointed to the mother’s distress and anxiety during pregnancy through embryonic planning, influencing the planning of the hypothalamic-pituitary-adrenal (HPA) axis and epigenetic changes. The intestinal microbiota is a part of a complex link named the microbiota-gut-brain axis that can affect drug abuse through the variety and number of intestinal microbiota. On the other hand, a mother’s drug consumption during pregnancy can function as chronic stress by affecting the enteric nervous system (ENS), which activates the concurrent axis of HPA and dopamine pathways by changing the reward circuit and the subsequent increase in drug abuse. The results indicated that various factors, such as exposure to adverse childhood experiences (ACEs), parental separation, and attachment insecurity, increase the probability of drug abuse in adulthood. Nevertheless, the quality of nurturing care during the first 1000 days of life and the mother’s warm relationship with children may hinder the increase in addiction in society. Conclusions: The first 1000 days of one's life are a crucial and delicate stage. If these days are tainted with unpleasant events, the various mechanisms can reduce a person's resilience to drug abuse in later life. How the first 1000 days of an infant’s life and the quality of this period, such as prenatal stress, substance use during pregnancy, ACEs, maternal-infant bonding, maternal separation (MS), and intestinal microbiota, can affect drug abuse in the future. As a result, focusing on the first 1000 days of life is critical to adapting prevention strategies. Health policymakers can design suitable entries during pregnancy and early childhood to reduce the probability of drug abuse.

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“…Traumatic stress, especially during developmental years, is one of the primary suspects for predisposition toward substance abuse, both in terms of neurophysiological changes as well social and lifestyle variables. Preliminary evidence has also shown associations between adverse childhood experiences and dysregulation with the neuroendocrine, gastrointestinal, and immune systems, all of which have been associated with increased risk of addiction (Horn et al, 2018;Salavrakos et al, 2021). These can further exacerbate mental health symptoms and impair frontal regions required for healthy reward and inhibition, thus further propelling the cycle of substance abuse (Le et al, 2021).…”

Section: Ashlie Bellmentioning

confidence: 99%

Proceedings of the 2022 ISNR Annual Conference: Keynote and Plenary Presentations

Research¹

2022

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The human brain is a magnificent tapestry of billions of neurons, trillions of synaptic connections with axons woven into a network of nodes and thousands of fiber tracks or edges. Together, these structures constitute the connectome or "the wiring diagram" of the brain. How the "wiring" occurs is dependent upon neuroplasticity, genetic and epigenetic factors: transgenerational experiences, environment

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Neuroendocrine and immune pathways from pre- and perinatal stress to substance abuse

Cited by 15 publications

References 154 publications

Developmental Pathways from Genetic, Prenatal, Parenting and Emotional/Behavioral Risk to Cortisol Reactivity and Adolescent Substance Use: A TRAILS Study

Developmental Pathways from Genetic, Prenatal, Parenting and Emotional/Behavioral Risk to Cortisol Reactivity and Adolescent Substance Use: A TRAILS Study

The First 1000 Days of Life and the Risk of Future Drug Consumption

Proceedings of the 2022 ISNR Annual Conference: Keynote and Plenary Presentations

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