Neuroethology application for the study of human temporal lobe epilepsy: From basic to applied sciences

Looking for complexity in quantitative semiology of frontal and temporal lobe seizures using neuroethology and graph theory

“…In patients with TLE, the most common form of focal epilepsy in adulthood, previous semiological studies of epileptic seizures using neuroethological tools have shown great potential to reveal localizing and lateralizing signals, such as the presence of epigastric aura, the lateralization value of dystonias, the impairment of consciousness and speech during ictal and postictal periods, and the development of secondary generalization [1,2]. The neuroethology-SPECT correlation in TLE was an effective tool to reliably evaluate ictal behavior and the functionally associated brain areas.…”

“…Some of these studies (mostly about TLE) have intended to standardize the terminology [2,14,15] or to quantify human epileptic seizure behaviors [2,[14][15][16][17]. A detailed analysis of the ictal semiology can often provide lateralizing or localizing signs that disclose valuable information about the location of the EZ and the pathways potentially involved in seizure propagation [18].…”

A semi-automated algorithm for studying neuronal oscillatory patterns: A wavelet-based time frequency and coherence analysis

“…Our laboratory has traditionally studied the behavioral expression of epileptic seizures by analyzing the interaction between behavioral components during ictal episodes (Dal-Cól et al, 2006;Garcia-Cairasco et al, 1996). The introduction of the simultaneous recording of LFPs and ictal behaviors through video-EEG recordings prompted us to develop an analytical tool to evaluate the spectral time course of specific behaviors.…”

Correlation of the patterns of behavior in focal epileptic seizures and localization of the epileptic lesions

“…Verovatno statistički najzahtevnija i najminucioznija klaster analiza semioloških osobina epileptičnih napada urađena je u centru u Sao Paolu (85). Ovo je, zapravo, bila prva neuroetološka studija u kliničkoj epileptologiji (neuroetologija -evolucioni i komparativni pristup proučavanju ponašanja i postojeće kontrole centralnog nervnog sistema).…”

“…U neuroetološkoj analizi, koja je učinjena na ukupno 7 bolesnika, pokazana je jedna sekvenca koja odgovara prvom podklasteru u našoj analizi: napad počinje aurom posle koje se nastavlja bihejvioralni arest i oroalimentarni automatizmi (85) (Slika 1.4).…”