Neurofilament subunit NF-H modulates axonal diameter by selectively slowing neurofilament transport.

Marszalek, Joseph R.; Williamson, Toni; Lee, Michael K.; Xu, Zuoshang; Hoffman, Paul N.; Bêcher, Mark W.; Crawford, Thomas O.; Cleveland, Don W.

doi:10.1083/jcb.135.3.711

Cited by 184 publications

(130 citation statements)

References 53 publications

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“…We speculate that testosterone affects axonal caliber, perhaps by influencing the number and/or properties of microtubules and/or neurofilaments (Marszalek et al, 1996;Hoffman et al, 1987). This view is consistent with the pathology of Kennedy disease, as well as with experimental findings of testosterone-induced upregula- tion of ␤-tubulin expression (Butler et al, 2001;Matsumoto et al, 1993).…”

Section: Discussionsupporting

confidence: 75%

Growth of White Matter in the Adolescent Brain: Role of Testosterone and Androgen Receptor

et al. 2008

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The growth of white matter during human adolescence shows a striking sexual dimorphism; the volume of white matter increases with age slightly in girls and steeply in boys. Here, we provide evidence supporting the role of androgen receptor (AR) in mediating the effect of testosterone on white matter. In a large sample of typically developing adolescents (n= 408, 204 males), we used magnetic resonance imaging and acquired T1-weighted and magnetization transfer ratio (MTR) images. We also measured plasma levels of testosterone and genotyped a functional polymorphism in the AR gene, namely the number of CAG repeats in exon 1 believed to be inversely proportional to the AR transcriptional activity. We found that the testosterone-related increase of white-matter volume was stronger in male adolescents with the lower versus higher number of CAG repeats in the AR gene, with testosterone explaining, respectively, 26 and 8% of variance in the volume. The MTR results suggest that this growth is not related to myelination; the MTR decreased with age in male adolescents. We speculate that testosterone affects axonal caliber rather than the thickness of the myelin sheath.

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Section: Discussionsupporting

confidence: 75%

Growth of White Matter in the Adolescent Brain: Role of Testosterone and Androgen Receptor

et al. 2008

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“…Thus, the stationary NFs network is a determinant of half-life and axonal transport rate of NF-L proteins. (Collard et al, 1995;Marszalek et al, 1996;Xu and Tung, 2000) as well as by excess of peripherin (Millecamps et al, 2006). NF transport in the sciatic nerve was found to be increased after NF-H or NF-M deletion (Zhu et al, 1998;Jacomy et al, 1999).…”

Section: Discussionmentioning

confidence: 82%

Conditional NF-L Transgene Expression in Mice forIn VivoAnalysis of Turnover and Transport Rate of Neurofilaments

Millecamps¹,

Gowing²,

Corti³

et al. 2007

J. Neurosci.

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“…These filaments are often arranged as loosely packed bundles oriented parallel to the axon length and can be extensively cross-linked (Nakagawa et al, 1995). The extent of neurofilament gene expression is correlated to axonal bore diameter, which controls the longitudinal resistance of the fiber, influencing the spacing between nodes of Ranvier and thereby how fast electrical signals traverse the axon Marszalek et al, 1996). Microtubules are the "highways" of transport for materials moving rapidly within the axons of neurons (Li et al, 2004) and have a diameter of about 24 nm; they vary in length from several hundred nanometers to hundreds of micrometers in axons.…”

Section: Introductionmentioning

confidence: 99%

Electron tomographic analysis of cytoskeletal cross-bridges in the paranodal region of the node of Ranvier in peripheral nerves

Perkins

Sosinsky

Ghassemzadeh

et al. 2008

Journal of Structural Biology

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The node of Ranvier is a site for ionic conductances along myelinated nerves and governs the saltatory transmission of action potentials. Defects in the cross-bridging and spacing of the cytoskeleton is a prominent pathologic feature in diseases of the peripheral nerve. Electron tomography was used to examine cytoskeletal-cytoskeletal, membrane-cytoskeletal, and heterologous cell connections in the paranodal region of the node of Ranvier in peripheral nerves. Focal attachment of cytoskeletal filaments to each other and to the axolemma and paranodal membranes of the Schwann cell via narrow cross-bridges was visualized in both neuronal and glial cytoplasms. A subset of intermediate filaments associates with the cytoplasmic surfaces of supramolecular complexes of transmembrane structures that are presumed to include known and unknown junctional proteins. Mitochondria were linked to both microtubules and neurofilaments in the axoplasm and to neighboring smooth endoplasmic reticulum by narrow cross-bridges. Tubular cisternae in the glial cytoplasm were also linked to the paranodal glial cytoplasmic loop juxtanodal membrane by short cross-bridges. In the extracellular matrix between axon and Schwann cell, junctional bridges formed long cylinders inking the two membranes. Interactions between cytoskeleton, membranes, and extracellular matrix associations in the paranodal region is likely critical not only for scaffolding, but also for intracellular and extracellular communication.

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Neurofilament subunit NF-H modulates axonal diameter by selectively slowing neurofilament transport.

Abstract: Abstract. To examine the mechanism through which

Cited by 184 publications

References 53 publications

Growth of White Matter in the Adolescent Brain: Role of Testosterone and Androgen Receptor

Growth of White Matter in the Adolescent Brain: Role of Testosterone and Androgen Receptor

Conditional NF-L Transgene Expression in Mice forIn VivoAnalysis of Turnover and Transport Rate of Neurofilaments

Electron tomographic analysis of cytoskeletal cross-bridges in the paranodal region of the node of Ranvier in peripheral nerves

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