Neurogenic Sexual Dysfunction Treatment: A Systematic Review

Popolo, Giulio Del; Cito, Gianmartin; Lepri, Gemma; Natali, Alessandro

doi:10.1016/j.euf.2019.12.002

Cited by 18 publications

(9 citation statements)

References 46 publications

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“…From a vascular perspective, ED can be secondary to atherosclerotic disease, which limits blood flow to the penile vasculature and prevents adequate erection (27)(28)(29). Neurologically, if there is compromise at any level of the nervous system leading to the innervation of the penis, this can also result in ED (30,31). From a psychologic perspective, if a patient is experiencing stress, depression, marital complications or other psychologic states, he may not experience an erection upon initiating sexual activity, but will still experience nocturnal erections, which are generally unaffected by psychologic state (32).…”

Section: Introductionmentioning

confidence: 99%

Erectile Dysfunction in Men With Psoriatic Arthritis: A Population-based Cohort Study

et al. 2020

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Objective To define the incidence of erectile dysfunction (ED) in a population-based cohort of men with psoriatic arthritis (PsA). Methods Data pertaining to demographics, ED, and potential confounding diagnosis were extracted from a comprehensive medical record system for a population-based cohort of men with PsA and an age-matched male comparator cohort. Cumulative incidence of ED adjusted for competing risk of death was compared between the two cohorts. Results There were 128 age-matched pairs of men with PsA and without PsA in the described cohorts. At baseline there was a 7% prevalence of ED in men with PsA prior to diagnosis compared to a 3% prevalence of ED in the comparator cohort (p=0.16). After PsA diagnosis / index date, diagnosis with PsA was associated with an increased risk of ED (age-adjusted HR 1.45, 95%CI: 0.79-2.68), but this association did not reach statistical significance. This was based on 24 cases of ED in the men with PsA and 18 cases within the comparator cohort. No confounding factors or ED treatment strategies differed significantly between men with PsA and ED and comparators with ED. Conclusion Men with PsA may have an increased risk of ED, which was detected, but likely underpowered in this study. Whether this difference is secondary to higher prevalence of traditional risk factors of ED in men with PsA compared to general population will require further study.

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Section: Introductionmentioning

confidence: 99%

Erectile Dysfunction in Men With Psoriatic Arthritis: A Population-based Cohort Study

et al. 2020

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“…This method is not suitable for male or female rats with internal reproductive organ problems. Furthermore, the impact of species differences on the application of our findings to humans requires clarification [6,[23][24][25][26][27][28][29].…”

Section: Discussionmentioning

confidence: 99%

Effects of unilateral/bilateral amputation of the ischiocavernosus muscle in male rats on erectile function and conception

Gou

Liu

Chen

et al. 2022

Basic Clin. Androl.

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Background The ischiocavernosus muscle (ICM) encompasses a pair of short pinnate muscles attached to the pelvic ring. The ICM begins at the ischial tuberosity and ends at the crus of the penis while covering the surface of the crus. According to the traditional view, the contraction of the ICM plays an auxiliary role in penile erection. However, we have previously shown that the ICM plays an important role in penile erection through an indirect method of diagnosing erectile dysfunction (ED) caused by ICM injury by observing the infertility of paired female rats. Since intracavernosal pressure (ICP) is the current gold standard for diagnosing ED, this study aimed to amputate unilaterally/bilaterally the ICM to establish an ED model by detecting the ICP, recording the infertility of matching female rats, and comparing the two methods. Results Forty sexually mature adult male rats were selected and randomly divided into the following groups: the control group (n = 10), sham operation group (n = 10), unilateral ischiocavernosus muscle (Uni-ICM) amputation group (n = 10), and bilateral ischiocavernosus muscle (Bi-ICM) amputation group (n = 10). Eighty female reproductive rats were randomly assigned to the above groups at a ratio of 2:1. We evaluated the time to conception for the paired female rats and the effects of unilateral/bilateral severing of the ICM on erectile function. The results showed that the baseline and maximum intracavernosal pressure (ICP) in the control group, sham operation group, Uni-ICM amputation group, and Bi-ICM amputation group were 17.44±2.50 mmHg and 93.51±10.78 mmHg, 17.81±2.81 mmHg and 95.07±10.40 mmHg, 16.73±2.11 mmHg and 83.49±12.38 mmHg, and 14.78±2.78 mmHg and 33.57±6.72 mmHg, respectively, immediately postsurgery. The max ICP in the Bi-ICM amputation group was lower than that in the remaining three groups (all P<0.05). The pregnancy rates were 100, 100, 90, and 0% in the control group, sham operation group, Uni-ICM amputation group, and the Bi-ICM amputation group, respectively. The pregnancy rate in the Bi-ICM amputation group was significantly lower than that in the remaining groups (all P<0.05). The time to conception was approximately 7–10 days later in the Uni-ICM amputation group than in the control and sham groups (all P<0.05). Conclusions Male rats undergoing Bi-ICM amputation may develop permanent ED, which affects their fertility. In contrast, rats undergoing Uni-ICM amputation may experience transient ED.

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“…Moreover, systemic prostaglandins have been applied in cardiology for managing pulmonary hypertension [ 31 ], in obstetrics for inducing childbirth or abortion [ 32 ], in urology for treating erectile dysfunction [ 33 ], in pediatrics for preventing closure of ductus arteriosus in newborns [ 34 ], and some other fields. Our analysis raises a question that if the synergic effect also exists in such systemic conditions.…”

Section: Discussionmentioning

confidence: 99%

The influence of topical non-steroidal anti-inflammatory drugs on the intraocular pressure lowering effect of topical prostaglandin analogues—A systemic review and meta-analysis

Hwang

et al. 2020

PLoS ONE

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Purpose This study aimed to review previous articles and evaluate the influence of topical non-steroidal anti-inflammatory drugs (NSAIDs) on intraocular pressure (IOP) in glaucoma patients who were treated with prostaglandin analogues (PGs). Method The presenting study was designed as a meta-analysis of previous research. Databases include PubMed, Web of science, Cochrane library, and Embase were searched with keywords of “intraocular pressure, prostaglandin analogues, NSAIDs, latanoprost, travoprost, bimatoprost, tafluprost, unoprostone, latanoprostene bunod, ketorolac, diclofenac, nepafenac, bromfenac, flurbiprofen”. Inclusion criteria were: 1. Study population were glaucoma patients; 2. Comparison between PGs monotherapy and PGs in combination with topical NSAIDs; 3. Changes of IOP as final outcomes. Studies with non-randomized design, treatments combining other anti-glaucomatous drugs, or unavailable absolute IOP were excluded from the analysis. Estimated difference in IOP were calculated using STATA 14.0. Result Seven studies were retrieved for this meta-analysis. Since there is a significant heterogeneity (I 2 = 94%) in these studies, random-effect model was used to calculate pooled standardized mean differences (SMD). Our results showed a significantly favorable IOP lowering effect in glaucoma patients treated with combination of topical NSAIDs and PGEs (SMD: 1.3 and -0.03, 95% CI: 0.29 to 2.38 and -0.32 to 0.26, Z = 2.50 and 0.23, p = 0.013 and 0.820, respectively). Conclusion Results of our meta-analysis suggested that topical NSAIDs may enhance the IOP lowering effect of topical PGs in glaucoma patients.

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Neurogenic Sexual Dysfunction Treatment: A Systematic Review

Cited by 18 publications

References 46 publications

Erectile Dysfunction in Men With Psoriatic Arthritis: A Population-based Cohort Study

Erectile Dysfunction in Men With Psoriatic Arthritis: A Population-based Cohort Study

Effects of unilateral/bilateral amputation of the ischiocavernosus muscle in male rats on erectile function and conception

The influence of topical non-steroidal anti-inflammatory drugs on the intraocular pressure lowering effect of topical prostaglandin analogues—A systemic review and meta-analysis

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