Neurogranin expression regulates mitochondrial function and redox balance in endothelial cells

Jorgensen, Ashton N.; Rashdan, Nabil A.; Rao, K.N. Shashanka; Delgadillo, Luisa F.; Kolluru, Gopi K.; Krzywanski, David M.; Pattillo, Christopher B.; Kevil, Christopher G.; Nam, Hyung W.

doi:10.1016/j.redox.2024.103085

Redox Biology

2024

DOI: 10.1016/j.redox.2024.103085

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Neurogranin expression regulates mitochondrial function and redox balance in endothelial cells

Ashton N. Jorgensen,

Nabil A. Rashdan,

K.N. Shashanka Rao

et al.

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2025

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Cited by 3 publications

References 64 publications

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Central SGLT2 mediate sympathoexcitation in hypertensive heart failure via attenuating subfornical organ endothelial cGAS ubiquitination to amplify neuroinflammation: Molecular mechanism behind sympatholytic effect of Empagliflozin

Zhang,

Huang,

Han

et al. 2025

International Immunopharmacology

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Central SGLT2 mediate sympathoexcitation in hypertensive heart failure via attenuating subfornical organ endothelial cGAS ubiquitination to amplify neuroinflammation: Molecular mechanism behind sympatholytic effect of Empagliflozin

Zhang,

Huang,

Han

et al. 2025

International Immunopharmacology

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Mitochondrial metabolism and redox signaling

Müller-Eigner,

Wojtovich

2024

Redox Biology

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Chromogranin B Protects Human Umbilical Endothelial Cells against Oxidative Stress

Grossini,

Venkatesan,

Ola Pour

et al. 2024

IJMS

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Chromogranin B (CgB) is involved in the control of the cardiovascular system through the regulation of catecholamine release. Whether CgB can exert direct actions on the endothelium has not yet been clarified. Here, we aimed to investigate the effects of CgB on cell viability, mitochondrial membrane potential, reactive oxygen species (ROS), glutathione (GSH), nitric oxide (NO) release, and the cytosolic calcium concentration ([Ca2+]c) in human vascular endothelial cells (HUVECs) cultured under both physiological and peroxidative conditions. In HUVECs, experiments were conducted to establish the proper concentration and timing of CgB stimulation. Thereafter, specific assays were used to evaluate the response of HUVECs cultured in physiologic or oxidative stress conditions to CgB in the presence or absence of β-adrenergic receptor agonists and antagonists and intracellular pathways blockers. Analysis of cell viability, mitochondrial membrane potential, and NO release revealed that CgB was able to cause increased effects in HUVECs cultured in physiological conditions. Additionally, the same analyses performed in HUVECs cultured with H2O2, showed protective effects exerted by CgB, which was also able to counteract ROS release and maintain GSH levels. Furthermore, CgB played a dual role on the [Ca2+]c depending on the physiological or peroxidative cell culturing conditions. In conclusion, our data provide new information about the direct role of CgB in the physiological regulation of endothelial function and highlight its potential as a protective agent against peroxidative conditions, such as those found in cardiovascular diseases.

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Neurogranin expression regulates mitochondrial function and redox balance in endothelial cells

Cited by 3 publications

References 64 publications

Central SGLT2 mediate sympathoexcitation in hypertensive heart failure via attenuating subfornical organ endothelial cGAS ubiquitination to amplify neuroinflammation: Molecular mechanism behind sympatholytic effect of Empagliflozin

Central SGLT2 mediate sympathoexcitation in hypertensive heart failure via attenuating subfornical organ endothelial cGAS ubiquitination to amplify neuroinflammation: Molecular mechanism behind sympatholytic effect of Empagliflozin

Mitochondrial metabolism and redox signaling

Chromogranin B Protects Human Umbilical Endothelial Cells against Oxidative Stress

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