Neuroimmunomodulation via Limbic Structures — The Neuroanatomy of Psychoimmunology

Haas, Helga Susanne; Schauenstein, Konrad

doi:10.1016/s0301-0082(96)00055-x

Cited by 123 publications

(61 citation statements)

References 385 publications

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“…Parece que a provável explicação para o fato, sejam alterações sofridas durante o desenvolvimento do eixo Hipotálamo-Hipófise-Adrenal (HPA) que sofre influên-cia de núcleos hipotalâmicos sexualmente diferenciados, sendo capazes de alterar a resposta imune induzida experimentalmente. 17,20,21 O sistema imune também sofre influências diretas do sistema endócri-no. Estudos recentes mostram que as células T e B são alvos da ação dos hormô-nios sexuais 20,21,22 .…”

Section: Introductionunclassified

Efeitos da castração pós-natal sobre o tecido pulmonar após sepse experimental de origem abdominal em ratos

et al. 2004

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OBJETIVO: Avaliar os efeitos da castração pós-natal sobre o tecido pulmonar na sepse de origem abdominal induzida em ratos. MÉTODOS: Foram utilizados 33 ratos Wistar distribuídos em dois grupos: Grupo Controle (GC) = 5 machos adultos normais sem desafio séptico. Grupo Experimento (GE): 28 ratos submetidos a sepse por ligadura e perfuração de ceco (LPC) e distribuídos em três subgrupos: Subgrupo Macho (SgM): nove ratos machos adultos, sem castracão e submetidos a sepse por LPC. Subgrupo Fêmea (SgF): nove ratos fêmeas adultos normais submetidas a sepse por LPC. Subgrupo Castrado (SgC): dez ratos machos que no quarto dia de vida foram submetidos a orquiectomia bilateral e quando adultos à sepse por LPC. Após a LPC os animais foram observados até o óbito, realizada análise histomorfométrica do pulmão, observando-se o número de polimorfonucleares e mononucleares. RESULTADOS: 50% dos animais do SgC sobreviveram 24 horas, contra 33% do SgF e 0% do SgM, mostrando uma nítida influência da castração na resposta ao desafio séptico. O número de polimorfonucleares e mononucleares não foi diferente estatisticamente entre o SgC e CG, estando estatisticamente aumentados no SgM e SgF. CONCLUSÃO: Os animais castrados apresentaram uma maior tendência à sobrevida e menor alteração pulmonar.

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Section: Introductionunclassified

Efeitos da castração pós-natal sobre o tecido pulmonar após sepse experimental de origem abdominal em ratos

et al. 2004

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“…Of note, relevant receptors for proinflammatory cytokines are expressed in abundance in the basal ganglia (Gray et al, 2001;Haas and Schauenstein, 1997), and chronic infusion of lipopolysaccharide, a potent inducer of the proinflammatory cytokine cascade, into the rat brain has been shown to induce a progressive and selective degeneration of nigral dopaminergic neurons through microglial activation (Gao et al, 2002). More specifically related to IFN-a, IFN-a receptors have been identified throughout the brain especially in microglia (Yamada and Yamanaka, 1995).…”

mentioning

confidence: 99%

Basal Ganglia Hypermetabolism and Symptoms of Fatigue during Interferon-α Therapy

Capuron

Pagnoni

Demetrashvili

et al. 2007

Neuropsychopharmacol

208

175

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Interferon (IFN)-a is a cytokine of the innate immune response that is well known for inducing behavioral alterations and has been used to study effects of cytokines on the nervous system. Limited data, however, are available on the sites of action of IFN-a within the brain and their relationship with specific IFN-a-induced symptoms. Using a longitudinal design, whole-brain metabolic activity as assessed by fluorine-18-labeled fluorodeoxyglucose uptake and positron emission tomography was examined before and 4 weeks after IFN-a administration in patients with malignant melanoma. Changes in metabolic activity in relevant brain regions were then correlated with IFN-a-induced behavioral changes. IFN-a administration was associated with widespread bilateral increases in glucose metabolism in subcortical regions including the basal ganglia and cerebellum. Decreases in dorsal prefrontal cortex glucose metabolism were also observed. Prominent IFN-a-induced behavioral changes included lassitude, inability to feel, and fatigue. Correlational analyses revealed that self-reported fatigue (specifically as assessed by the 'energy' subscale of the Visual Analog Scale of Fatigue) was associated with increased glucose metabolism in the left nucleus accumbens and putamen. These data indicate that IFN-a as well as other cytokines of the innate immune response may target basal ganglia nuclei, thereby contributing to fatigue-related symptoms in medically ill patients.

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“…23 Saturable transport mechanisms exist for these and other cytokines and limbic cortical areas bear receptors for them. 24 Indeed, central (intracerebroventricular) or peripheral administration of pro-inflammatory cytokines promotes reliable increases in ACTH release. 12 …”

Section: Irj Psych Med 1999; 16(3): 82-83mentioning

confidence: 99%

Neuroimmune mechanisms in cancer: implications for psychiatry

Garland

Walsh

1999

Ir. j. psychol. med.

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Neuroimmunomodulation via Limbic Structures — The Neuroanatomy of Psychoimmunology

Cited by 123 publications

References 385 publications

Efeitos da castração pós-natal sobre o tecido pulmonar após sepse experimental de origem abdominal em ratos

Efeitos da castração pós-natal sobre o tecido pulmonar após sepse experimental de origem abdominal em ratos

Basal Ganglia Hypermetabolism and Symptoms of Fatigue during Interferon-α Therapy

Neuroimmune mechanisms in cancer: implications for psychiatry

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