2015
DOI: 10.1002/glia.22899
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Neuroinflammation in the peripheral nerve: Cause, modulator, or bystander in peripheral neuropathies?

Abstract: The role of innate and adaptive inflammation as a primary driver or modifier of neuropathy in premorbidly normal nerves, and as a critical player in amplifying neuropathies of other known causes (e.g., genetic, metabolic) is incompletely understood and under‐researched, despite unmet clinical need. Also, cellular and humoral components of the adaptive and innate immune system are substantial disease modifying agents in the context of neuropathies and, at least in some neuropathies, there is an identified tight… Show more

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Cited by 77 publications
(61 citation statements)
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“…Neuro‐inflammation is an event in which nerve endings are stimulated by inflammation. On the other hand, activated nerve fibers may maintain and increase tissue inflammation by evoking further release of pro‐inflammatory molecules (ie, known as neurogenic inflammation) . These mechanisms may contribute to visceral hypersensitivity and pain persistence both during acute inflammation and after inflammation has subsided .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Neuro‐inflammation is an event in which nerve endings are stimulated by inflammation. On the other hand, activated nerve fibers may maintain and increase tissue inflammation by evoking further release of pro‐inflammatory molecules (ie, known as neurogenic inflammation) . These mechanisms may contribute to visceral hypersensitivity and pain persistence both during acute inflammation and after inflammation has subsided .…”
Section: Discussionmentioning
confidence: 99%
“…These mechanisms may contribute to visceral hypersensitivity and pain persistence both during acute inflammation and after inflammation has subsided . Macrophages are key immune cells participating in these events . The intricate cross‐talk between immune and nervous system is mediated by several molecules.…”
Section: Discussionmentioning
confidence: 99%
“…Glial cells, which receive information from both primary afferent terminals and pain transmission neurons, can be sensitively activated by a wide array of substances, such as excitatory amino acids, nitric oxide, prostaglandins, tissue/nerve injury, and pathogens (Cury et al, ; Ji et al, ; Mika et al, ; Bobba et al, ; Martini and Willison, ; Old et al, ; Ni et al, ). The microglia and astrocytes respond to increased input from the periphery by producing and secreting diverse pronociceptive mediators, such as cytokines, chemokines, and ATP (Jha et al, ; Old et al, ).…”
Section: Discussionmentioning
confidence: 99%
“…Huntington's disease, as well as in CLN1 and diabetic neuropathy (Martini & Willison, 2016;Ray et al, 2016;Saha et al, 2008). Whether this pathway is a promising target for treatment approaches in some of these CNS disorders should be investigated in the future.…”
Section: Amyotophic Lateral Sclerosismentioning
confidence: 99%