Neurokinin-2 receptor polymorphism predicts lymph node metastasis in colorectal cancer patients

Fang, Weijia; Fu, Caiyun; Chen, Xiaogang; Mou, Xiaozhou; Liu, Fanlong; Qian, Jiong; Zhao, Peng; Zheng, Yulong; Zheng, Yi; Deng, Jing; Ye, Pingjiang; Wang, Yifei; Zheng, Shusen

doi:10.3892/ol.2015.3016

Cited by 9 publications

(15 citation statements)

References 23 publications

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“…In midgut carcinoid tumors, patients with persistent plasma NKA levels had significantly worse survival than patients with stabilized or downregulated plasma NKA levels 44 . Moreover, a previous paper indicated that NK2R gene polymorphisms predicted lymph node metastasis in CRC patients 45 . In our study, we found that NK2R was overexpressed in the tumor tissues of patients with CRC and high expression was associated with poor survival from the analysis based on TCGA public dataset 46,47 .…”

Section: Discussionsupporting

confidence: 51%

“… 44 Moreover, a previous paper indicated that NK2R gene polymorphisms predicted lymph node metastasis in CRC patients. 45 In our study, we found that NK2R was overexpressed in the tumor tissues of patients with CRC and high expression was associated with poor survival from the analysis based on TCGA public dataset. 46 , 47 Based on these findings, we speculate not only that NKA signaling through NK2R may be related to the development and malignancy of CRC, but also that NKA–NK2R expression levels may be useful biomarkers to evaluate the malignancy of colon cancers.…”

Section: Discussionmentioning

confidence: 59%

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IFN‐α/β‐mediated NK2R expression is related to the malignancy of colon cancer cells

et al. 2022

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Neurokinin 2 receptor (NK2R), a G protein‐coupled receptor for neurokinin A (NKA), a tachykinin family member, regulates various physiological functions including pain response, relaxation of smooth muscle, dilation of blood vessels, and vascular permeability. However, the precise role and regulation of NK2R expression in cancer cells have not been fully elucidated. In this study, we found that high NK2R gene expression was correlated with the poor survival of colorectal cancer patients, and Interferon (IFN‐α/β) stimulation significantly enhanced NK2R gene expression level of colon cancer cells in a Janus kinas 1/2 (JAK 1/2)‐dependent manner. NKA stimulation augmented viability/proliferation and phosphorylation of Extracellular‐signal‐regulated kinase 1/2 (ERK1/2) levels of IFN‐α/β‐treated colon cancer cells and NK2R blockade by using a selective antagonist reduced the proliferation in vitro. Administration of an NK2R antagonist alone or combined with polyinosinic‐polycytidylic acid, a synthetic analog of double‐stranded RNA, to CT26‐bearing mice significantly suppressed tumorigenesis. NK2R‐overexpressing CT26 cells showed enhanced tumorigenesis and metastatic colonization in both lung and liver after the inoculation into mice . These findings indicate that IFN‐α/β‐mediated NK2R expression is related to the malignancy of colon cancer cells, suggesting that NK2R blockade may be a promising strategy for colon cancers.

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Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 59%

IFN‐α/β‐mediated NK2R expression is related to the malignancy of colon cancer cells

et al. 2022

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“…Via migration and invasion, one primary tumor could spread to several organs and form multiple metastases. Colorectal cancer, for example, may form liver metastasis [27], lung metastasis [28], bone metastasis [29] and lymph node metastasis [30]. It has been reported that ATAD2 is highly expressed in colorectal cancer, and it is associated with liver metastasis, lymph node metastasis and poor prognosis of colorectal cancer patients [16].…”

Section: Discussionmentioning

confidence: 99%

Silencing of ATPase family AAA domain-containing protein 2 inhibits migration and invasion of colorectal cancer cells

Hong¹,

Bi²,

Yan³

et al. 2016

neo

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Colorectal cancer is one of the most common malignant tumors with a high rate of distant metastasis, postoperative recurrence and mortality. ATPase family AAA domain-containing protein 2 (ATAD2), a member of ATPase family, is highly expressed in various cancers, including colorectal cancer. However, whether ATAD2 plays a role in the migration and invasion of colorectal cancer cells remains unknown. In this study, we established ATAD2 knockdown in colorectal cancer cell lines by RNA interference and found that silencing of ATAD2 inhibited the migration and invasion ability of Caco-2 and SW-480 cells. Moreover, ATAD2 silencing suppressed epithelial-mesenchymal transition (EMT), and reduced the expression and enzymatic activity of matrix metalloproteinases (MMPs) in Caco-2 and SW-480 cells. In summary, our results suggest that silencing of ATAD2 inhibits migration and invasion of colorectal cancer cells by suppressing EMT and decreasing the activity of MMPs. Hence, ATAD2 could be considered as a novel molecular marker of metastatic colorectal cancer, and it may provide new insights for clinical diagnosis and treatment of colorectal cancer.

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“…Abnormal expression of tachykinin receptor coding genes was found in breast cancer, colon cancer, and other tumors. Nevertheless, the role of TACR2 in cancer progression remains unclear [ 11 – 13 ].…”

Section: Introductionmentioning

confidence: 99%

TACR2 is associated with the immune microenvironment and inhibits migration and proliferation via the Wnt/β-catenin signaling pathway in prostate cancer

Wang

2021

Cancer Cell Int

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Background The tachykinin receptor 2 (TACR2) is encoded by the tachykinin receptor correlation gene. Recent microarray analysis for prostate cancer suggests that TACR2 expression is associated with clinical phenotype and disease-free survival among patients with prostate cancer. Results TACR2 protein levels were lower in prostate cancer tissues than in adjacent normal prostate tissue. TACR2 expression significantly correlated with clinical stage, Gleason scores, and survival outcomes. TACR2 expression positively correlated with mast cells and negatively correlated with M2 macrophages. Overexpression of TACR2 promoted the migration and proliferation of prostate cancer cells by regulating the Wnt signaling pathway. Conclusions The TACR2-Wnt/β-catenin signaling pathway is critical in prostate cancer. TACR2 may affect tumor cells’ occurrence and development by changing the content of immune cells in the tumor microenvironment. These findings suggest that TACR2 may be a candidate molecular biomarker for prostate cancer therapy.

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Neurokinin-2 receptor polymorphism predicts lymph node metastasis in colorectal cancer patients

Cited by 9 publications

References 23 publications

IFN‐α/β‐mediated NK2R expression is related to the malignancy of colon cancer cells

IFN‐α/β‐mediated NK2R expression is related to the malignancy of colon cancer cells

Silencing of ATPase family AAA domain-containing protein 2 inhibits migration and invasion of colorectal cancer cells

TACR2 is associated with the immune microenvironment and inhibits migration and proliferation via the Wnt/β-catenin signaling pathway in prostate cancer

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