Neurologic and histopathologic evaluation after high-volume intrathecal amitriptyline

Sudoh, Yukari; Desai, Sukumar P.; Haderer, Anna E.; Sudoh, Shinji; Gerner, Peter; Anthony, Douglas C.; Girolami, Umberto De; Wang, Ging Kuo

doi:10.1016/j.rapm.2004.06.008

Cited by 41 publications

(19 citation statements)

References 23 publications

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“…Staining was done by using hematoxylin and eosin as described by Sudoh et al 36 Microscopic examinations were performed under 450X light microscopy (scale bar 35 μm).…”

Section: Histopathological Evaluation Of Sciatic Nervementioning

confidence: 99%

Ameliorative potential of ferulic acid in vincristine-induced painful neuropathy in rats: An evidence of behavioral and biochemical examination

Vashistha

Sharma

Jain

2016

Nutritional Neuroscience

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The present study was designed to investigate the effect of ferulic acid (FA) in vincristine-induced neuropathic pain in rats. Vincristine (50 µg/kg, i.p. for 10 consecutive days) was administered to induce painful neuropathy in rats. Various pain sensitive tests, viz., pinprick, hot plate, paint-brush, and acetone test were performed on different days (1, 6, 14, and 21) to assess the degree of mechanical hyperalgesia, heat hyperalgesia, mechanical dynamic allodynia, and cold allodynia, respectively. The electrophysiological and histopathological evaluations were also investigated. The tissue thiobarbituric acid reactive species (TBARS), reduced glutathione (GSH), myeloperoxidase (MPO), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-10 (IL-10), and total calcium were measured as the markers of inflammation and oxidative stress. FA (50 and 100 mg/kg, i.p.) and gabapentin (10 mg/kg, p.o.) were administered for 11 days. Administration of FA attenuated the vincristine-induced behavioral alteration along with electrophysiological and histopathological changes significantly (P < 0.05). FA also attenuated the vincristine-induced oxidative stress (TBARS, GSH, and total calcium levels) and inflammation (MPO, TNF-alpha, IL-6, and IL-10). It may be concluded that FA has ameliorative potential in mitigation of the painful states associated with vincristine-induced painful neuropathy that may further be attributed to anti-inflammatory actions with subsequent reduction in oxidative stress.

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“…Staining was done by using hematoxylin and eosin as described by Sudoh et al 36 Microscopic examinations were performed under 450X light microscopy (scale bar 35 μm).…”

Section: Histopathological Evaluation Of Sciatic Nervementioning

confidence: 99%

Ameliorative potential of ferulic acid in vincristine-induced painful neuropathy in rats: An evidence of behavioral and biochemical examination

Vashistha

Sharma

Jain

2016

Nutritional Neuroscience

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“…Staining was done by using hematoxylin and eosin as described by the method of Sudoh et al (2004). The nerve sections were analyzed qualitatively under light microscope (450×) for axonal degeneration.…”

Section: Histopathological Evaluation Of the Sciatic Nervementioning

confidence: 99%

Standardized fruit extract of Momordica charantia L protect against vincristine induced neuropathic pain in rats by modulating GABAergic action, antimitotoxic, NOS inhibition, anti-inflammatory and antioxidative activity

Jain

Pareek

Ratan

et al. 2015

South African Journal of Botany

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In the present experimental work, we investigate the protective potential of standardized Momordica charantia L fruit extract [gallic acid (GA) 6%; N8% bitters {momordicosides K (3%) and L (2%); and momordicines I (2%) and II (3%)}] (MC) comparable to its marker compound gallic acid in chemo-toxic neuropathy induced by vincristine [75 μg/kg intra-peritoneal (i.p.) for 10 consecutive days] in rats. An array of behavioral examinations was carried out on days 1st, 12th and 21st, followed by various biochemical and histopathological studies at the end. Vincristine significantly induced cold and dynamic mechanical allodynia, mechanical and heat hyperalgesia; functional deficit in walking and a rise in the levels of TNF-α, IL 6, mitochondrial complexes, myeloperoxidase (MPO), thiobarbituric acid reactive substances (TBARS), and nitrite along with decrease in glutathione (GSH). Administration of MC [400 and 800 mg/kg, per oral (p.o.)], GA (30 mg/kg, p.o.) and gabapentin (100 mg/kg, p.o.) attenuated the vincristine induced behavioral and biochemical changes. MC demonstrated superior antinociceptive activity in comparison to GA. Histopathological evaluation also divulged defending the effects of MC. Pretreatment of saclofen (1 mg/kg, i.p.), picrotoxin (1 mg/kg, i.p.) upturned the antinociceptive action of MC, but ingestion of GABA (100 mg/kg, i.p.) potentiated the action of MC. Additionally, pretreatment with L-arginine [nitric oxide (NO) donor; 100 mg/kg, i.p.] inverted the antinociceptive action of MC; whereas, aminoguanidine (iNOS inhibitor) and 7-nitroindazole (nNOS inhibitor) potentiated it. Besides this a PPARγ antagonist BADGE did not amend the effect of MC. Corroboratively, the attenuating effect of MC in vincristine induced neuropathy is attributed to its modulating action on GABAergic system along with antimitotoxic, NOS inhibition, anti-inflammatory and anti oxidative activities.

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“…Staining was carried out by using hematoxylin and eosin as described in the method of Sudoh et al (2004). Nerve sections were analyzed qualitatively under light microscope (450 Â ) for axonal degeneration.…”

Section: Histopathological Evaluationmentioning

confidence: 99%

Neuroprotective effect of saponin rich extract of Acorus calamus L. in rat model of chronic constriction injury (CCI) of sciatic nerve-induced neuropathic pain

Muthuraman

Singh

2012

Journal of Ethnopharmacology

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Neurologic and histopathologic evaluation after high-volume intrathecal amitriptyline

Cited by 41 publications

References 23 publications

Ameliorative potential of ferulic acid in vincristine-induced painful neuropathy in rats: An evidence of behavioral and biochemical examination

Ameliorative potential of ferulic acid in vincristine-induced painful neuropathy in rats: An evidence of behavioral and biochemical examination

Standardized fruit extract of Momordica charantia L protect against vincristine induced neuropathic pain in rats by modulating GABAergic action, antimitotoxic, NOS inhibition, anti-inflammatory and antioxidative activity

Neuroprotective effect of saponin rich extract of Acorus calamus L. in rat model of chronic constriction injury (CCI) of sciatic nerve-induced neuropathic pain

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