Neurological Manifestations in Systemic  Lupus Erythematosus: A Single Centre  Study from North East India

Kakati, Sanjeeb; Barman, Bhupen; Ahmed, Sobur U; Hussain, Masaraf

doi:10.7860/jcdr/2017/23773.9280

Cited by 25 publications

(34 citation statements)

References 21 publications

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“…Симптомы психоза в нашей когорте больных наблюдались в 72,34% случаев, в виде слуховых и зрительных галлюцинаций, которые в большей степени ассоциировались с СКВ (76,47%), язвенным стоматитом (58,82%), нефритом с нефротическим синдромом (29,41%), с повышением уровня анти-ДНК (82,35%), антител к SmD1-антигену (26,47%), дефицитом С3-, С4компонентов комплемента (61,76%). По данным литературы, наиболее часто встречающимися нейропсихическими расстройствами являются тревожно-депрессивные (28-40%), тревожные состояния (24-70%) и расстройства адаптации с тревожной и депрессивной симптоматикой (19-46%) [23][24][25]. Тревожно-депрессивные расстройства были выявлены всего у 5 наших больных.…”

Section: Discussionunclassified

Clinical and laboratory manifestations of systemic lupus erythematosus in patients with neuropsychiatric disorders (eurasian renaissance register)

Koilubaeva

Асеева

Соловьев

et al. 2019

Naučno-praktičeskaâ revmatologiâ

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О р и г и н а л ь н ы е и с с л е д о в а н и я 1 Национальный Центр кардиологии и терапии (НЦКТ) им. академика М. Миррахимова, Бишкек, Кыргызская Республика; 2 ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»,

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Section: Discussionunclassified

Clinical and laboratory manifestations of systemic lupus erythematosus in patients with neuropsychiatric disorders (eurasian renaissance register)

Koilubaeva

Асеева

Соловьев

et al. 2019

Naučno-praktičeskaâ revmatologiâ

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“…По данным литературы, наиболее часто встречающимися нейропсихическими расстройствами являются тревожно-депрессивные (28-40%), тревожные состояния (24-70%) и расстройства адаптации с тревожной и депрессивной симптоматикой (19-46% пациентов) [45][46][47]. У наших пациентов тревожно-депрессивные расстройства были выявлены всего в пяти случаях.…”

Section: показатель значениеunclassified

Neuropsychic manifestations in the Kyrgyz cohort of patients with systemic lupus erythematosus

Koilubaeva

Решетняк

Асеева³

et al. 2019

Naučno-praktičeskaâ revmatologiâ

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The aimof the investigation was to study neuropsychic manifestations (NPM) of systemic lupus erythematosus (SLE) in the Kyrgyz cohort of patients.Material and methods.The prospective study included 460 patients with a reliable diagnosis of SLE, verified according to the diagnostic criteria ACR (1997) and SLICC (2012), observed in the clinic of the Academician M. Mirrakhimov National Center of Cardiology and Therapy from january 2012 to december 2017. Signs of nervous system damage were revealed in 103 (22.39%) of 460 patients with SLE. Classification criteria of ACR (1999) were used to assess neuropsychic manifestations of SLE, which were diagnosed by the psychiatrist according to ICD-10. Cognitive disorders were detected by a psychologist using a specific test Mini-Mental State Examination (MMSE; mini-scheme study of the mental state of the patient).Results and discussion.Various signs of NPM SLE were revealed in 103 (22.39%) of 460 patients with SLE. Groups of patients with and without NPM SLE at the beginning of the study were comparable in age, time from the appearance of the first signs of SLE to the verification of the diagnosis and the value of the SLEDAI-2K index (p>0.05). Acute variant of SLE course was significantly associated with NPM SLE. The acute course of SLE was observed in 56 (54.38%) of the 103 patients with NPM SLE and 109 (30.53%) of the 357 patients without NPM SLE [odds ratio (OR) 2.71, 95% confidence interval (CI) of 1.73–4.24; p<0.001]. Subacute and chronic course of the disease was diagnosed in a similar number of patients with NPM SLE – 24 (23.30%) and without NSAIDS – 23 (23.33%) (OR 5.75 95% CI 3.54–9.34; p<0.001). In the majority of patients the central nervous system (CNS) lesions prevailed. It was present in 71 (68.93%) patients, peripheral nervous system (PNS) pathology was less frequent and revealed in 32 (31.07%) of 103 cases, and 4 (3.88%) patients had combined CNS and PNS lesions. One manifestation of NPM SLE was detected in 37 (52.11%) patients, two – in 15 (21.13%), three – in 14 (19.72%) and four – in 5 (7.04%) of 71 patients with CNS lesions. According to the criteria of ACR (1999) in 103 patients 155 different NPM SLE were diagnosed: CNS disorders – in 123 (79.35%) and PNS pathology – in 32 (20.65%). The frequency of focal and diffuse CNS disorders was 61.79% and 38.21%, respectively. Cerebrovascular disease (CVD) was diagnosed most frequently – in 33 (43.42%) of the 76 cases of focal neuropsychiatric CNS disorders. Clinical manifestations of CVD were mainly characterized by discirculatory encephalopathy – in 30 (90.91%), less often – by ischemic stroke in the middle cerebral artery basin on the left – in 2 (6.06%) and transient ischemic attack – in 1 (3.03%) of 33 CVD cases. One manifestation was present in 52.11% of patients with CNS pathology. In other cases, there were more symptoms of its damage. Among the 47 diffuse lesions, neuropsychic disorders of the psychosis type prevailed, the main manifestations of which were visual and auditory hallucinations – in 34 (72.34%) patients.Conclusion.NPM SLE was identified in 22.39% of patients. Acute variant of SLE and very high activity was associated with NPM SLE. The risk of NPM SLE developing in very high activity of SLE was increased by 5.75 times. In the vast majority of cases in Kyrgyz patients there was CNS involvement (68.93%), twice less – PNS damage (31.07%), combined lesion of PNS and CNS was noted less frequently (3.88%). 47.89% of patients had more than one manifestation of NPM SLE. In most patients with diffuse NPM SLE, psychosis was observed in the form of visual and auditory hallucinations (72.34%), and focal ones were presented by CVD (43.42%), usually in the form of discirculatory encephalopathy (90.91%).

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“…Eine Enzephalopathie (60 % aller Neurolupus-Fälle), epileptische Anfälle (60 %), zerebrovaskuläre Durchblutungsstörungen und Hirnnervenausfällen sind häufig. Bewegungsstörungen wie choreatische Syndrome oder Ataxien treten seltener auf, ebenso wie Polyneuropathien, Myopathien und Myelitiden (21).…”

Section: Kollagenosen Mit Beteiligung Des Zentralen Und Peripheren Neunclassified

Entzündlich-rheumatische Erkrankungen und neurologische Manifestationen

Röther¹,

Bickel²,

Kötter³

2018

Arthritis und Rheuma

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ZusammenfassungEntzündliche Erkrankungen des peripheren und zentralen Nervensystems sind oft eine Herausforderung, und regelmäßig stellt sich die Frage nach einer entzündlich-rheumatischen Grunderkrankung. Die Erstdiagnose einer Vaskulitis oder einer Kollagenose erfolgt sowohl in der Neurologie als auch in der Rheumatologie und daher benötigen Rheumatologen neurologisches Symptomwissen und Neurologen ein Verständnis der entzündlich-rheumatischen Krankheitszeichen. Die diagnostische Zuordnung kann eindeutig sein, wenn typische Symptomkonstellationen vorhanden und diagnostische Kriterien seitens der zerebralen Bildgebung und der Labordiagnostik passend sind. Häufig ist aber der Nachweis einer entzündlich-rheumatologischen Erkrankung erschwert, und eine enge Kooperation zwischen dem neurologischen und rheumatologischen Fachgebiet ist sinnvoll. Wir geben nachfolgend eine Übersicht über die häufigsten neurologischen Manifestationen entzündlich-rheumatologischer Erkrankungen und deren moderne Therapieoptionen.

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Neurological Manifestations in Systemic Lupus Erythematosus: A Single Centre Study from North East India

Cited by 25 publications

References 21 publications

Clinical and laboratory manifestations of systemic lupus erythematosus in patients with neuropsychiatric disorders (eurasian renaissance register)

Clinical and laboratory manifestations of systemic lupus erythematosus in patients with neuropsychiatric disorders (eurasian renaissance register)

Neuropsychic manifestations in the Kyrgyz cohort of patients with systemic lupus erythematosus

Entzündlich-rheumatische Erkrankungen und neurologische Manifestationen

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