Neuromodulatory effects of offline low-frequency repetitive transcranial magnetic stimulation of the motor cortex: A functional magnetic resonance imaging study

Min, Yu-Sun; Park, Jang Woo; Jin, Seong Uk; Jang, Kyung Eun; Lee, Byung‐Joo; Lee, Hui Joong; Lee, Jongmin; Lee, Yang-Soo; Chang, Yongmin; Jung, Tae-Du

doi:10.1038/srep36058

Cited by 16 publications

(14 citation statements)

References 44 publications

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“…Numerous investigations have proved that the aberrant spontaneous neural activity and functional networks of several diseases could be modulated by using repetitive transcranial magnetic stimulation (rTMS) through changing the excitability of the site of stimulation as well as the distant anatomically connected sites [16][17][18][19][20][21][22]. Previous rTMS studies on patients with cognition impairment in Alzheimer's disease, Parkinson's disease, schizophrenia, and dementia in older patients have reported significant positive effectiveness on improving cognitive ability [23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

High-Frequency Repetitive Transcranial Magnetic Stimulation Could Improve Impaired Working Memory Induced by Sleep Deprivation

Jiang

McClure

et al. 2019

Neural Plasticity

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Objective. To investigate whether and how the working memory impairment induced by sleep deprivation (SD) could be recovered by using repetitive transcranial magnetic stimulation (rTMS), as well as to clarify the corresponding brain activity changes. Methods. Seventeen healthy adults received one session of 5.0 Hz rTMS over the left dorsolateral prefrontal cortex (DLPFC) following 24 hours of SD. Resting state functional magnetic resonance imaging (fMRI) and working memory test were performed during a rested waking period, after SD and rTMS. The amplitude of low-frequency fluctuations (ALFF) was used to detect the spontaneous neural activity changes after both SD and rTMS. The relationship between ALFF and the performance of working memory was also assessed by using correlation analysis. Results. After SD, the participants exhibited lower response accuracies and longer reaction times on the working memory tests of letters and numbers. The decreased response accuracy of numbers was significantly improved after rTMS similarly to the state of the rested waking period after a normal night of sleep. ALFF values decreased from the rested waking period state to the state of SD in the brain regions involving the frontal gyrus, precuneus, angular gyrus, and parietal lobe which showed significantly increased ALFF after rTMS. Furthermore, significantly positive correlations were observed between changes of response accuracy and the changes of ALFF value of the inferior frontal gyrus and supramarginal gyrus. Conclusion. These results indicate that high-frequency rTMS applied over left DLPFC may contribute to the recovery of the impaired working memory after SD by modulating the neural activity of related brain regions.

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Section: Introductionmentioning

confidence: 99%

High-Frequency Repetitive Transcranial Magnetic Stimulation Could Improve Impaired Working Memory Induced by Sleep Deprivation

Jiang

McClure

et al. 2019

Neural Plasticity

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“…Using 50-Hz bursts of TMS (e.g., cTBS), decreased cortical excitability was reported lasting up to 60 min ( Huang et al, 2005 ). In addition, 1-Hz rTMS decreased cortical inhibition up to 30 min following the cessation of TMS ( Muellbacher et al, 2000 ; Gerschlager et al, 2001 ), which was also shown by a decreased fMRI neural activity for up to 20 min ( Min et al, 2016 ).…”

Section: Short- and Long-term Effects Of Nibs On Cortical Excitabilitmentioning

confidence: 88%

Insights Into Auditory Cortex Dynamics From Non-invasive Brain Stimulation

2018

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Non-invasive brain stimulation (NIBS) has been widely used as a research tool to modulate cortical excitability of motor as well as non-motor areas, including auditory or language-related areas. NIBS, especially transcranial magnetic stimulation (TMS) and transcranial direct current stimulation, have also been used in clinical settings, with however variable therapeutic outcome, highlighting the need to better understand the mechanisms underlying NIBS techniques. TMS was initially used to address causality between specific brain areas and related behavior, such as language production, providing non-invasive alternatives to lesion studies. Recent literature however suggests that the relationship is not as straightforward as originally thought, and that TMS can show both linear and non-linear modulation of brain responses, highlighting complex network dynamics. In particular, in the last decade, NIBS studies have enabled further advances in our understanding of auditory processing and its underlying functional organization. For instance, NIBS studies showed that even when only one auditory cortex is stimulated unilaterally, bilateral modulation may result, thereby highlighting the influence of functional connectivity between auditory cortices. Additional neuromodulation techniques such as transcranial alternating current stimulation or transcranial random noise stimulation have been used to target frequency-specific neural oscillations of the auditory cortex, thereby providing further insight into modulation of auditory functions. All these NIBS techniques offer different perspectives into the function and organization of auditory cortex. However, further research should be carried out to assess the mode of action and long-term effects of NIBS to optimize their use in clinical settings.

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“…These results could be related to individual clinical applications and mechanisms. Recent studies have indicated that with LF-rTMS (1 Hz) stimulation of the contralateral cerebral M1 area, the vicinal cortical activity signal decreased, inhibiting the stimulated cerebral cortex activation, and this stimulated effect can last for 20 minutes after treatment [46]. Some experimental studies have shown that 1 Hz LF-rTMS can increase action potential and excitatory postsynaptic current in hippocampal CA1 neurons, which inhibit cortical excitability [47].…”

Section: Discussionmentioning

confidence: 99%

Scalp acupuncture plus low-frequency rTMS promotes repair of brain white matter tracts in hemiplegic patients with stroke: A diffusion tensor imaging study

Zhao

Zhang

Qiu

et al. 2018

J. Integr. Neurosci.

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To study the clinical effects of scalp acupuncture plus low frequency rTMS in hemiplegic stroke patients. A total of 28 hemiplegic stroke patients were recruited and randomly assigned to the experimental group (scalp acupuncture low frequency rTMS routine rehabilitation treatment) or the control group (scalp acupuncture routine rehabilitation treatment). All patients received a diffusion tensor imaging examination on the day of admission and on the fourteenth day. Compared with pre-treatment, the upper limb motor function score and ability of daily life score increased significantly in the two groups, and motor function improvement was much greater in the experimental group. Fractional anisotropy values significantly increased in white matter tracts, such as the corticospinal tract, forceps minor, superior longitudinal fasciculus and uncinate fasciculus in the two groups. Compared with pretreatment, the fractional anisotropy values increased and mean diffusion values decreased synchronously in the forceps minor, left inferior fronto-occipital fasciculus, left inferior longitudinal fasciculus, left superior longitudinal fasciculus and left uncinate fasciculus in the experimental group. Before and after treatment, there were no significant differences in the changes of fractional anisotropy values between the two groups, but the changes of the mean diffusion values in the experimental group were much greater than those in the control group in the left superior longitudinal fasciculus and the left uncinate fasciculus (p < 0.05). Moreover, the increased fractional anisotropy values in the forceps minor in the experimental group were significantly positively correlated with the increased Fugl-Meyer assessment score. Our study concluded that based on routine rehabilitation treatment, scalp acupuncture plus low frequency rTMS can promote white matter tracts repair better than scalp acupuncture alone; the motor function improvement of the hemiplegic upper limb may be closely related to the rehabilitation of the forceps minor; the combination of scalp acupuncture and low frequency rTMS is expected to provide a more optimal rehabilitation protocol for stroke hemiplegic patients.

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Neuromodulatory effects of offline low-frequency repetitive transcranial magnetic stimulation of the motor cortex: A functional magnetic resonance imaging study

Cited by 16 publications

References 44 publications

High-Frequency Repetitive Transcranial Magnetic Stimulation Could Improve Impaired Working Memory Induced by Sleep Deprivation

High-Frequency Repetitive Transcranial Magnetic Stimulation Could Improve Impaired Working Memory Induced by Sleep Deprivation

Insights Into Auditory Cortex Dynamics From Non-invasive Brain Stimulation

Scalp acupuncture plus low-frequency rTMS promotes repair of brain white matter tracts in hemiplegic patients with stroke: A diffusion tensor imaging study

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